Name: binocular dynamic visual acuity in eyeglass-corrected myopic patients
Uploaded: 2022-03-29T15:00:00
Description: Watch this Scientific Journal Video about Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients at JoVE.com

这项工作得到了北京市自然科学基金（7202229）的支持。

本研究纳入了北京大学第三医院眼科的连续近视患者。该研究方案由北京大学第三医院伦理委员会批准，并获得了每位参与者的知情同意。
1. 患者准备
<ol><li>使用以下初始纳入标准来招募受试者：17-45 岁的近视受试者。</li>
	<li>使用以下排除标准：任何显著影响矫正远视力 （CDVA） 的眼部疾病史，包括角膜炎、青光眼、白内障、视网膜和黄斑疾病。评估未矫正?...

<ol>
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C. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Comparing+sports+vision+among+three+groups+of+soft+tennis+adolescent+athletes:+Normal+vision,+refractive+errors+with+and+without+correction.">Comparing sports vision among three groups of soft tennis adolescent athletes: Normal vision, refractive errors with and without correction.</a> Indian Journal of Ophthalmology. 63 (9), 716-721 (2015).</li><li>Dacey, D. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Physiology,+morphology+and+spatial+densities+of+identified+ganglion+cell+types+in+primate+retina.">Physiology, morphology and spatial densities of identified ganglion cell types in primate retina.</a> Ciba Foundation Symposium. 184, 12-34 (1994).</li><li>Lee, M. W., Nam, K. Y., Park, H. J., Lim, H. B., Kim, J. Y. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Longitudinal+changes+in+the+ganglion+cell-inner+plexiform+layer+thickness+in+high+myopia:+a+prospective+observational+study.">Longitudinal changes in the ganglion cell-inner plexiform layer thickness in high myopia: a prospective observational study.</a> British Journal of Ophthalmology. 104 (5), 604-609 (2020).</li><li>Seo, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Ganglion+cell-inner+plexiform+layer+and+retinal+nerve+fiber+layer+thickness+according+to+myopia+and+optic+disc+area:+a+quantitative+and+three-dimensional+analysis.">Ganglion cell-inner plexiform layer and retinal nerve fiber layer thickness according to myopia and optic disc area: a quantitative and three-dimensional analysis.</a> BMC Ophthalmology. 17 (1), 22 (2017).</li><li>Zhang, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=eyeglass+wear,+and+risk+of+bicycle+accidents+among+rural+Chinese+secondary+school+students:+the+Xichang+Pediatric+Refractive+Error+Study+report+no.+7.">eyeglass wear, and risk of bicycle accidents among rural Chinese secondary school students: the Xichang Pediatric Refractive Error Study report no. 7.</a> Archives of Ophthalmology. 127 (6), 776-783 (2009).</li></ol>

DVA是评估视觉功能的一个有希望的指标，可以更好地反映日常生活中的实际视力。近视患者本可以矫正正常的SVA，但他们的DVA可能会受到影响。本研究展示了一种通过眼镜矫正准确检查近视受试者DVA的方法，并分析其与验光参数（包括屈光，调节和优势眼）的相关性。结果表明，40 dps时的DVA优于80 dps时的DVA。屈光状态越接近屈光，眼镜矫正DVA在40和80 dps时越好。DVA和调节功能参数与优势眼之间没?...

目前的视觉评估主要集中在静态视觉上，包括静态视力（SVA）、视野和对比敏感度。在日常生活中，物体或观察者经常处于运动状态，而不是静止不动。因此，SVA可能无法充分反映日常生活中的视觉功能，尤其是当物体高速移动时，例如在运动和驾驶过程中1。DVA定义了识别移动视型1，2细节的能力，这可能更好地反映现实生活中的情况，并且对视觉障碍和改善更敏感3，4。此外，由于主要位于周边视网膜的巨细胞（M）神经节细胞主要传输高时间频率信号，DVA可能与SVA5，6不同地反射视觉信号传输。DVA测试（DVAT）主要可分为两种类型：静态和运动物体DVAT。静态物体DVAT显示前庭眼反射7，8，9，10，而移动物体DVAT通常用于临床眼科，以检测识别运动目标的视力3，4。
近几十年来，近视患病率迅速上升，特别是在亚洲国家11。近视对静态未矫正远视力有重要影响，可以用各种镜片矫正。眼镜主要用于近视患者，因为可及性和便利性。然而，眼镜，尤其是高度近视镜片，具有明显的周边散焦和棱镜效应，导致通过周边区域12，13，14，15观察到不清晰和歪斜的图像。对于静态视型，受试者通常使用眼镜的中心区域，以获得清晰的视力。然而，移动的目标很容易移出眼镜的最清晰点。因此，通过眼镜矫正，近视受试者的SVA可能正常并受到影响DVA。然而，尚未进行任何研究来调查近视屈光度对戴眼镜人群DVA的影响。
本研究展示了一种检查眼镜矫正近视患者DVA的方法，旨在探讨近视屈光度对眼镜矫正患者移动物体双眼DVA的影响。该研究为准确解释临床眼科DVAT提供了基础，考虑了眼镜的影响和矫正近视对运动相关活动影响的证据。

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>Automatic computer optometry</td>
			<td>TOPCON</td>
			<td>KR8100</td>
			<td></td>
		</tr>
		<tr>
			<td>Corneal topography</td>
			<td>OCULUS</td>
			<td>Pentacam</td>
			<td></td>
		</tr>
		<tr>
			<td>Dynamic visual acuity test design software</td>
			<td>Mathworks</td>
			<td>matlab 2017b</td>
			<td></td>
		</tr>
		<tr>
			<td>Fundus photography</td>
			<td>Optos</td>
			<td>Daytona</td>
			<td></td>
		</tr>
		<tr>
			<td>Matlab</td>
			<td>Mathworks</td>
			<td>2017b</td>
			<td></td>
		</tr>
		<tr>
			<td>Noncontact tonometry</td>
			<td>CANON</td>
			<td>TX-20</td>
			<td></td>
		</tr>
		<tr>
			<td>Phoropter</td>
			<td>&#160;NIDEK</td>
			<td>RT-5100</td>
			<td></td>
		</tr>
		<tr>
			<td>scientific statistical software</td>
			<td>IBM</td>
			<td>SPSS 26.0</td>
			<td></td>
		</tr>
		<tr>
			<td>Slit lamp</td>
			<td>Koniz</td>
			<td>IM 900</td>
			<td></td>
		</tr>
	</tbody>
</table>

binocular dynamic visual acuity in eyeglass-corrected myopic patients

目前的临床视觉评估主要集中在静态视觉上。然而，静态视觉可能无法充分反映现实生活中的视觉功能，因为每天经常观察到移动的视型。动态视敏度（DVA）可以更好地反映现实生活中的情况，尤其是当物体高速移动时。近视影响静态未矫正远视力，方便戴眼镜矫正。然而，由于周边散焦和棱镜效应，眼镜矫正可能会影响DVA。本研究展示了近视患者眼镜矫正DVA的标准检测方法，旨在探讨眼镜矫正对DVA的影响。 
最初，进行标准的主观屈光以提供眼镜处方以矫正屈光不正。然后，使用物体移动DVA协议检查双目远视力矫正DVA。软件旨在根据屏幕上的预设速度和尺寸显示移动视像。视型是标准的对数视觉图表字母E，在测试过程中从左侧中间水平移动到右侧。将显示具有每种尺寸的随机打开方向的移动视型。要求受试者识别视型的开放方向，DVA定义为受试者可以识别的最小视型，根据对数视敏度算法计算。
然后，该方法应用于181名眼镜矫正至正常静态视力的年轻近视受试者。检查优势眼、睫状麻痹主观屈光（球体和圆柱体）、调节函数（负和正相对调节、双眼交叉圆柱）以及每秒 40 度和 80 度 （dps） 的双眼 DVA。结果表明，随着年龄的增长，DVA先升高后降低。当用眼镜完全矫正近视时，更差的双眼DVA与更显着的近视屈光不正有关。优势眼、调节功能和双眼DVA之间没有相关性。

科目考试 对于入组受试者，按上述顺序检查了调节函数，包括负相对调节（NRA），调节反应（双眼交叉圆柱（BCC））和正相对调节（PRA）。使用基于主观屈光的远距离视力矫正眼镜测试40 dps和80 dps的双眼DVA。
统计分析 使用科学的统计软件进行统计分析。连续变量的描述性统计量报告为平均值和标准差，并对分类变量应用数字和比例。双眼差异?...

Watch this Scientific Journal Video about Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients at JoVE.com

Binocular Dynamic Visual Acuity in Eyeglass-Corrected Myopic Patients

本研究展示了一种通过眼镜矫正准确检查近视受试者动态视力（DVA）的方法。进一步的分析表明，屈光状态越接近屈光不正，眼镜矫正双眼DVA在每秒40度和80度时的效果越好。

眼镜矫正近视患者的双眼动态视力

Current clinical visual assessment mainly focuses on static vision. However, static vision may not sufficiently reflect real-life visual function as ...

近视是眼科诊所的常见问题，会影响视力。本方案展示了一种方便的方法，用于检查眼镜矫正近视患者的动态视力。本方案在检查近视患者动态视力方面是标准和有效的，学习曲线短，因此可以很容易地在眼科诊所推广。动态视力测试可应用于各种疾病和情况，包括白内障和屈光手术。与静态视敏度相比，它可能更好地反映现实生活中的视觉功能。首先，执行自动计算机验光作为主观屈光的主要数据，并测量瞳孔距离。一次检查一只眼睛并遮挡另一只眼睛。使用加 0.75 至正 1.0 屈光度镜片实现最大正到最大视力雾化，诱导 0.3 至 0.5 的视力。然后逐渐降低正镜片或每步将负镜片增加0.25屈光度。使用兰开斯特红绿色测试来调整准确的球形屈光度。如果患者报告在红色或绿色背景下看到的字母更清晰，请添加更多的阴性和阳性镜片。通过将杰克逊十字圆柱装置放置在轴位置来细化圆柱轴，使拇指轮连接线平行于散光轴。旋转拇指轮，并要求受试者比较两侧之间的清晰度。将圆柱轴转向侧面十字圆柱上的红点，视野更清晰。重复二进制比较，直到终点。通过转动杰克逊十字圆柱装置来优化圆柱功率，使拇指轮的连接线与散光轴成 45 度。旋转拇指轮并要求受试者比较两侧之间的清晰度。如果患者报告沿圆柱轴线放置的十字圆柱体红色或白色点连接线更好，则添加阴镜片或正镜片。重复二进制比较，直到终点。重复兰开斯特红绿色测试，将准确的球面屈光度调整为第二个最大加最大视力。为了保持双眼平衡，在一只眼睛前应用六棱镜度的垂直棱镜，以分离双眼视觉。平衡两只眼睛之间光电类型的清晰度。根据要求调整测试距离。调整座位，使拍摄对象看到屏幕的中点水平。确保受试者戴上双目远视力矫正眼镜。通过在初始光电类型大小中设置光电类型移动速度来测试参数配置。对于预测试，显示五种随机打开方向的光电类型，以指导受试者对测试模式的理解。以比最佳校正DVA大三到四行的大小开始测试。显示具有随机打开方向的光电类型。告诉受试者识别移动光型的开口方向。在受试者的回答之后呈现下一个光电类型。为每种尺寸提供八种光电类型，以便每个确定的光电类型获得 0.1 logmar 视力的 1/8。如果正确识别了八种光电类型中的五种，请将光电类型调整为小一号。重复上述步骤，直到获得受试者可以识别的光电类型少于五种的大小。记录受试者可以识别的最小尺寸不少于八种光电类型中的五种，以及小一号识别的光电类型数量。根据文本手稿中所述的对数视力算法计算DVA。累积结果表明，75%的受试者每秒40度的DVA优于0.2，每秒80度DVA的受试者为62%。双眼DVA优于0.1 logmar 40度/秒的受试者百分比为22%对于每秒80度，百分比为12%曲线估计获得了显着结果，该曲线估计拟合了每秒40度的年龄DVA，具有二次曲线和立方曲线，但不是线性模型。对于每秒80度DVA，所有线性二次曲线和立方曲线都能够适当地拟合年龄DVA散点图。记录了单因素线性混合模型中各潜在影响因子对40度和80度/秒DVA的影响，并记录了统计结果。当使用每秒40度DVA测量变异性时，较高的单目和平均双眼球和球面当量是显著的负影响因素。同样，较大的单目和平均双目球体和球面当量是每秒80度DVA的显著负影响因素。因子和协变量对多因子线性混合模型的影响表明，较大的双目均值球面当量是每秒40度和80度DVA的显著负影响因子。年龄较大是每秒80度的重要负面影响因素。最重要的是让题主聚焦在移动的光片类型上，确定开场方向，在题主的回答之后呈现下一个光图类型。

Research

JoVE Journal

Medicine

Driving Simulation in the Clinic: Testing Visual Exploratory Behavior in Daily Life Activities in Patients with Visual Field Defects

驾驶模拟诊所：测试视觉与视野缺损的患者在日常活动中的探索行为

Patients suffering from homonymous hemianopia after infarction of the posterior cerebral artery (PCA) report different degrees of constraint in daily ...

科研

医学

Development of an Audio-based Virtual Gaming Environment to Assist with Navigation Skills in the Blind

基于音频的虚拟游戏环境的发展，以帮助盲人的导航技巧

Audio-based Environment Simulator (AbES) is virtual environment software designed to improve real world navigation skills in the blind. Using only audio ...

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Computerized dynamic posturography with the EquiTest is an objective technique for measuring postural strategies under challenging static and dynamic ...

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

动态视觉测试，以确定和量化视觉损伤与修复继脱髓鞘视神经炎患者

In order to follow optic neuritis patients and evaluate the effectiveness of their treatment, a handy, accurate and quantifiable tool is required to ...

Assessment of Vascular Function in Patients With Chronic Kidney Disease

血管功能在慢性肾脏疾病的评估

Patients with chronic kidney disease (CKD) have significantly increased risk of cardiovascular disease (CVD) compared to the general population, and this ...

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

视网膜胶质细胞活化的体内动力学在神经退行性疾病：共聚焦成像眼底及细胞形态计量小鼠青光眼

Microglia, which are CNS-resident neuroimmune cells, transform their morphology and size in response to CNS damage, switching to an activated state with ...

A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse

一个简单的机械过程来创建在小鼠角膜缘干细胞缺乏症

Limbal stem cell deficiency (LSCD) is a state of malfunction or loss of limbal epithelial stem cells, after which the corneal epithelium is replaced with ...

Fertility Preservation in Patients with Severe Ovarian Dysfunction

严重卵巢功能障碍患者的生育保护

Ovarian function progressively declines during aging and in some pathophysiological conditions including karyotype abnormality, autoimmune diseases, ...

Providing Visual Biofeedback Using Brightness Mode Ultrasound During a Golf Swing

在高尔夫挥杆期间使用亮度模式超声波提供视觉生物反馈

Using ultrasound biofeedback in conjunction with verbal cueing can increase muscle thickness more than verbal cueing alone and may augment traditional ...

Muscle Function Obtained with Motion Mode Ultrasound and Surface Electromyography during Core Endurance Exercise

核心耐力运动期间通过运动模式超声和表面肌电图获得的肌肉功能

Motion mode (M-mode) ultrasound allows researchers and clinicians to measure the change of muscle thickness across time. Muscle thickness can be measured ...