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JoVE Journal

Cancer Research

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Non-Invasive PET/MR Imaging in an Orthotopic Mouse Model of Hepatocellular Carcinoma

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Our methods creates a reliable hypoxic hepatocellular carcinoma model for noninvasive imaging of tumor hypoxia to study HCC biology in vivo, which can better recapitulate cancer development in humans. Our reliable HCC model together with a highly-

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Here, we present a protocol to create orthotopic hepatocellular carcinoma xenografts with and without hepatic artery ligation and perform non-invasive positron emission tomography (PET) imaging of tumor hypoxia using [18F]Fluoromisonidazole ([18F]FMISO) and [18F]Fluorodeoxyglucose ([18F]FDG).

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