Name: computer-aided three-dimensional visualization in the treatment of locally advanced thyroid cancer
Uploaded: 2023-06-09T14:20:00
Description: Watch this Scientific Journal Video about Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer at JoVE.com

作者没有致谢。

本研究方案经四川省肿瘤医院伦理委员会批准（批准日期：2019年9月27日）。所有涉及人类参与者的程序都是根据机构和国家研究委员会的道德标准以及 1964 年赫尔辛基宣言及其后来的修正案进行的。术前获得所有患者的书面知情同意书。
1. 纳入和排除标准
<ol><li>如果出现以下情况，则纳入患者：（1） 他们患有经病理证实的甲状腺癌并需要手术治疗;（2）局部?...

<ol>
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对于复发性和转移性分化型甲状腺癌 （DTC），手术治疗仍是首选17.DTC 和 R0 切除术患者的 5 年疾病特异性生存率为 94.4%，显著高于 R1 切除术患者的 67.9 %2。实现颈部疾病控制对于提高患者的生活质量和疾病特异性生存率至关重要4.甲状腺髓样癌主要通过手术治疗。因此，肿瘤完全切除在分化型甲状腺髓样癌18中具有重要意义。...

甲状腺癌是中国第七大常见恶性肿瘤1，手术是最重要的治疗方法2,3。肿瘤完全切除与局部晚期甲状腺癌患者的高生存率和良好的生活质量密切相关 3,4;然而，这种类型的切除术具有挑战性。颈部包含重要的器官和组织，如气管、食道和颈总动脉。晚期甲状腺癌的切除风险更大，难度更大，因为这些肿瘤靠近颈部和纵隔的重要器官和大血管5,6。因此，充分的术前评估是必要的。
目前，在临床环境中广泛使用的计算机断层扫描 （CT）、磁共振 （MRI） 和彩色多普勒超声提供了二维 （2D） 视图，这限制了对肿瘤体积、边界以及与重要周围结构的关系的评估 7,8。在外科医生将 2D 图像转换为 3D 空间之前，需要丰富的临床经验和有效的试错。计算机辅助3D可视化可以利用2D成像创建更直观的3D模型，可用于术前规划和治疗方案选择，从而使医患沟通更加直观，减少医患分歧。尽管该模型提供了 3D 可视化，但它是无形的。这种 3D 引导的术前评估和准备可以缩短手术时间并降低手术风险。3D 方法已广泛用于肝胆外科、骨科以及口腔颌面外科 9,10。在甲状腺癌中，3D可视化目前用于辅助超声诊断和手术计划的制定11,12,13,14,15。
因此，我们认为3D可视化可以方便地应用于局部晚期甲状腺癌的诊断和治疗。这种可视化方法包括 CT 采集、计算机辅助 3D 建模和使用 3D 模型的术前评估。3D 模型可用于确定手术难度、手术风险和潜在的术后功能状态。外科医生可以进行详细的医患沟通、制定手术计划以及相应的手术准备16.此外，这种方法可以在不增加患者创伤的情况下对患者进行充分的术前评估，降低手术风险并提高患者满意度。

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>Brilliance 256-layer spiral CT system</td>
			<td>Philips Healthcare, Andover, MA, USA</td>
			<td>N/A</td>
			<td>Used for plain and enhanced CT imaging</td>
		</tr>
		<tr>
			<td>3D-Matic digital medical software application</td>
			<td>Anhui King Star Digital S&#38;T Co. Ltd.</td>
			<td>N/A</td>
			<td>Used for computer-aided 3D visualization reconstruction</td>
		</tr>
	</tbody>
</table>

computer-aided three-dimensional visualization in the treatment of locally advanced thyroid cancer

局部晚期甲状腺癌的诊断和治疗具有挑战性。挑战在于肿瘤范围的评估和个体化治疗计划的制定。三维（3D）可视化在医学领域有着广泛的应用，尽管在甲状腺癌中的应用有限。我们之前将 3D 可视化应用于甲状腺癌的诊断和治疗。通过数据收集、3D建模和术前评估，我们可以获得有关肿瘤轮廓的3D信息，确定肿瘤浸润的程度，并进行充分的术前准备和手术风险评估。本研究旨在证明 3D 可视化在局部晚期甲状腺癌中的可行性。计算机辅助三维可视化是准确的术前评估、开发手术方法、缩短手术时间、降低手术风险的有效方法。此外，它还有助于医学教育和医患沟通。我们相信，3D可视化技术的应用可以改善局部晚期甲状腺癌患者的预后和生活质量。

2017 年 12 月至 2021 年 7 月，23 例局部晚期甲状腺癌患者接受了 3D 建模。在这 23 例患者中，4 例因手术风险而被排除在手术之外，其余 19 例患者在 3D 建模后接受手术治疗（表 1）。所有 19 例患者均患有局部晚期甲状腺癌，其中 14 例为初始诊断，16 例为不同程度的呼吸困难，18 例为颈部大肿瘤（原发性甲状腺肿瘤或转移性淋巴结）已侵入周围组织。术后病理评估显示，11例患者为分化?...

Watch this Scientific Journal Video about Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer at JoVE.com

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

在诊断和治疗局部晚期甲状腺癌时，计算机辅助三维重建的应用可以提供有关肿瘤范围和解剖特征的额外信息，从而协助风险评估和手术计划。

计算机辅助三维可视化治疗局部晚期甲状腺癌

The diagnosis and treatment of locally advanced thyroid carcinoma are challenging. The challenge lies in the evaluation of the tumor scope and the ...

计算机辅助三维重建可以提供有关肿瘤范围和解剖特征的信息，从而辅助风险评估和手术计划。计算机辅助三维重建可为局部晚期甲状腺癌的诊断和治疗提供信息。首先，使用 256 层螺旋 CT 系统获得患者的平板和增强 CT 图像。以DICOM格式从CT系统获取扫描数据。然后通过单击“打开”按钮将数据导入 3D 可视化软件。如果数据包含图像噪声，请先用鼠标右键单击数据，然后单击高斯平滑按钮，以处理数据以进行高斯平滑。接下来，根据要重建的结构（例如血管或皮肤）在软件中选择选项卡 不同的模型。设置颜色、最大阈值和最小阈值。根据观察到的预览效果调整上限和下限阈值。重复该过程以获取其他结构（如骨骼）的分割数据。点击计算按钮，完成初步的3D模型重建。然后使用平滑算法按钮优化分割数据，并确保重建的锯齿边缘与真实组织匹配。然后使用一键导航按钮定位 2D 和 3D 图像，并确定分割效果是否准确。使用钢笔或画笔工具修复不正确的图层。对于术前评估，查看 3D 模型并评估肿瘤体积和位置。利用放大、旋转、组织透明度和分离功能，使用各种结构的组合来评估肿瘤与邻近组织之间的关系。对于一名 50 岁的甲状腺癌患者，使用 CT 血管造影进行的初步评估表明肿瘤涉及大量血管。利用CT数据，手术团队完成了肿瘤的计算机辅助3D建模。对3D模型的评估揭示了肿瘤与血管之间的关系，并确定了进一步的手术程序。检查三维图像是否与CT图像一致对于成功重建非常重要。

Research

JoVE Journal

Medicine

Quantitative Visualization and Detection of Skin Cancer Using Dynamic Thermal Imaging

定量可视化和皮肤癌症使用动态热成像检测

In 2010 approximately 68,720 melanomas will be diagnosed in the US alone, with around 8,650 resulting in death 1. To date, the only effective treatment ...

科研

医学

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression

异型三维<em在体外</em&gt;卵巢癌的发生和发展过程中的间质 - 上皮细胞相互作用模型

Epithelial ovarian cancers (EOCs) are the leading cause of death from gynecological malignancy in Western societies. Despite advances in surgical ...

Human Neuroendocrine Tumor Cell Lines as a Three-Dimensional Model for the Study of Human Neuroendocrine Tumor Therapy

人类神经内分泌肿瘤细胞株为研究人类神经内分泌肿瘤治疗的三维模型

Neuroendocrine tumors (NETs) are rare tumors, with an incidence of two per 100,&#x200A;000 individuals per year, and they account for 0.5% of all human ...

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies

三维组织培养模型研究人类原发性骨髓和恶性肿瘤

Tissue culture has been an invaluable tool to study many aspects of cell function, from normal development to disease. Conventional cell culture methods ...

Three Dimensional Cultures: A Tool To Study Normal Acinar Architecture vs. Malignant Transformation Of Breast Cells

三维文化：一种工具来研究正常腺泡结构与恶性转化的乳腺细胞

Invasive breast carcinomas are a group of malignant epithelial tumors characterized by the invasion of adjacent tissues and propensity to metastasize. The ...

Quantification of Breast Cancer Cell Invasiveness Using a Three-dimensional (3D) Model

Quantification of Breast Cancer Cell Invasiveness Using a Three-dimensional 3D Model

乳腺癌细胞侵袭定量使用三维（3D）模型

It is now well known that the cellular and tissue microenvironment are critical regulators influencing tumor initiation and progression. Moreover, the ...

Three-dimensional Co-culture Model for Tumor-stromal Interaction

对于肿瘤基质相互作用的三维共培养模式

Cancer progression (initiation, growth, invasion and metastasis) occurs through interactions between malignant cells and the surrounding tumor stromal ...

Three-Dimensional (3D) Tumor Spheroid Invasion Assay

Three-Dimensional 3D Tumor Spheroid Invasion Assay

三维（3D）肿瘤球体侵袭试验

Invasion of surrounding normal tissues is generally considered to be a key hallmark of malignant (as opposed to benign) tumors. For some cancers in ...

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

研究胰腺癌干细胞特性开发新的治疗策略

Pancreatic ductal adenocarcinoma (PDAC) contains a subset of exclusively tumorigenic cancer stem cells (CSCs) which have been shown to drive tumor ...

Three-dimensional Alginate-bead Culture of Human Pituitary Adenoma Cells

人垂体腺瘤细胞的三维海藻酸钠珠文化

A three-dimensional culture method is described in which primary pituitary adenoma cells are grown in alginate beads. Alginate is a polymer derived from ...