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2.1K Views
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07:30 min
December 2nd, 2022
DOI :
10.3791/64527-v
Chapters
0:04
Introduction
1:20
Preparation of the Mice and Preoperative Setup and Dissection
3:24
Identification and Resection of the Ganglion
4:49
Results: Surgical Removal of the Superior Cervical Ganglion in Mouse Model
6:57
Conclusion
Transcript
交感神经系统在癌症进展和其他疾病中起着重要作用。手术交感神经切除术是通过诱导完全单侧肾上腺素能消融来研究这些过程的有价值的方法。该技术避免了与交感神经系统的药理学抑制相关的副作用。
此外,它比前面描述的方法侵入性更小,因为它避免了颈动脉的解剖。在执行这种技术时,可能很难进入神经节所在的正确空间并将其与脂肪区分开来。因此,确定地标和实践至关重要。
解剖结构在运动和未解剖时看起来略有不同,因此视觉演示为如何识别解剖标志提供了更好的指导,这是该技术的关键。首先将局部眼药膏
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Summary
本协议描述了通过识别和切除颈上神经节来消融肾上腺素能神经支配的小鼠模型。
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