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1.6K Views
•
08:19 min
December 16th, 2022
DOI :
10.3791/64582-v
Chapters
0:05
Introduction
1:05
Fetal Echocardiogram
1:46
Necropsy
2:41
Episcopic Confocal Microscopy (ECM)
4:01
Three-Dimensional (3D) Reconstruction
6:14
Results: Analyzing Cardiac Anomalies Using Echo and ECM
7:19
Conclusion
Transcript
该协议概述了生成高分辨率成像数据以诊断先天性心脏缺陷的尖端方法。我们通过无创胎儿超声心动图结合尸检进行功能评估,然后进行主教共聚焦显微镜组织病理学,以生成连续2D图像堆栈和3D重建,以进行全面的冠心病诊断。该方法不仅可以阐明先天性心脏病的详细解剖变化,还可以用于研究其他器官的结构出生缺陷,包括颅面缺陷,肢体和骨骼异常,以及大脑和其他内脏器官的缺陷。
展示这些程序的将是Meghan Holbrook,Carla Guzman,Peizhao Zhang和Benjamin Glen
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Summary
本文详细介绍了使用胎儿超声心动图、尸检和使用会落共聚焦显微镜 (ECM) 的会射荧光图像捕获 (EFIC) 然后进行三维 (3D) 重建的小鼠先天性心脏病 (CHD) 诊断方法。
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