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786 Views
•
08:41 min
March 24th, 2023
DOI :
10.3791/64838-v
Chapters
0:04
Introduction
1:06
Animal Preparation and Imaging Workflow
2:02
Evaluation of Hepatic Lipid Deposition/Steatosis
3:21
Functional Tissue Uptake/Lipid (Chylomicron) Transfer in the Liver
4:27
Architecture and Density of the Hepatic Vascular Network
5:32
Hepatic Relative Blood Volume
6:33
Results: Average Contrast Values and the Micro‐CT Imaging in Mice with NAFLD and Healthy Controls
7:50
Conclusion
Transcript
我们认为该协议具有重要意义,因为它展示了一种非侵入性简单易行的方法,可以随着时间的推移评估肝病诊断的关键指标。这种成像方法允许分析肝脏状态,评估相对血容量,门静脉直径,血管网络强度,肝脏病理学的所有重要参数。了解NAFLD进展期间肝血管网络的适应性并将其与特定标志物(如脂肪变性,炎症和纤维化)相关联,可以帮助建立新的有效治疗方案。
该技术有助于识别此类标志物,并提升小鼠在临床前研究中的价值,重点是开发针对疾病进展的新疗法。首先,将麻醉动物置于CT扫描仪摇篮中。涂抹眼药膏,固定鼻
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Summary
使用饮食诱导的非酒精性脂肪性肝病(NAFLD)小鼠模型,我们 描述了使用新型 体内微型计算机断层扫描成像技术作为评估NAFLD进展阶段的非侵入性方法,主要关注肝血管网络,因为它显着参与NAFLD相关的肝失调。
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