<meta charset="utf8"></head><body>Kardiyovasküler Değerlendirme için Arteriyel Sertlik ve Endotel Fonksiyonunun Kullanılması

<ol>
	<li>Csige, I., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+impact+of+obesity+on+the+cardiovascular+system.">The impact of obesity on the cardiovascular system.</a> J Diabetes Res. 2018, 3407306 (2018).</li><li>McAloon, C. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+changing+face+of+cardiovascular+disease+2000-2012:+An+analysis+of+the+World+Health+Organization+Global+Health+Estimates+data.">The changing face of cardiovascular disease 2000-2012: An analysis of the World Health Organization Global Health Estimates data.</a> Int J Cardiol. 224, 256-264 (2016).</li><li>Virdis, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Endothelial+dysfunction+in+obesity:+Role+of+inflammation.">Endothelial dysfunction in obesity: Role of inflammation.</a> High Blood Press Cardiovasc Prev. 23 (2), 83-85 (2016).</li><li>Medina-Leyte, D. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Endothelial+dysfunction,+inflammation+and+coronary+artery+disease:+Potential+biomarkers+and+promising+therapeutical+approaches.">Endothelial dysfunction, inflammation and coronary artery disease: Potential biomarkers and promising therapeutical approaches.</a> Int J Mol Sci. 22 (8), 3850 (2021).</li><li>Mikael, L. R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Vascular+aging+and+arterial+stiffness.">Vascular aging and arterial stiffness.</a> Arq Bras Cardiol. 109 (3), 253-258 (2017).</li><li>Liang, Y., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+Mechanisms+of+the+development+of+atherosclerosis+in+prediabetes.">The Mechanisms of the development of atherosclerosis in prediabetes.</a> Arq Bras Cardiol. 22 (8), 4108 (2021).</li><li>A&#231;ar, B., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Association+of+prediabetes+with+higher+coronary+atherosclerotic+burden+among+patients+with+first+diagnosed+acute+coronary+syndrome.">Association of prediabetes with higher coronary atherosclerotic burden among patients with first diagnosed acute coronary syndrome.</a> Angiology. 70, 174-180 (2019).</li><li>Amano, T., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Abnormal+glucose+regulation+is+associated+with+lipid-rich+coronary+plaque:+Relationship+to+insulin+resistance.">Abnormal glucose regulation is associated with lipid-rich coronary plaque: Relationship to insulin resistance.</a> JACC Cardiovasc Imaging. 1, 39-45 (2008).</li><li>Fan, J., Watanabe, T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Atherosclerosis:+Known+and+unknown.">Atherosclerosis: Known and unknown.</a> Pathol Int. 72 (3), 151-160 (2022).</li><li>Coutinho, M. S. S. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Abdominal+adiposity+and+intima-media+carotid+thickness:+An+Association.">Abdominal adiposity and intima-media carotid thickness: An Association.</a> Arq Bras Cardiol. 112 (3), 228-229 (2019).</li><li>Zanoli, L., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Arterial+stiffness+in+the+heart+disease+of+CKD.">Arterial stiffness in the heart disease of CKD.</a> J Am Soc Nephrol. 30 (6), 918-928 (2019).</li><li>Boutouyrie, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Arterial+stiffness+and+cardiovascular+risk+in+hypertension.">Arterial stiffness and cardiovascular risk in hypertension.</a> Circ Res. 128 (7), 864-886 (2021).</li><li>Ben-Shlomo, Y., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Aortic+pulse+wave+velocity+improves+cardiovascular+event+prediction:+An+individual+participant+meta-analysis+of+prospective+observational+data+from+17,635+subjects.">Aortic pulse wave velocity improves cardiovascular event prediction: An individual participant meta-analysis of prospective observational data from 17,635 subjects.</a> J Am Coll Cardiol. 63 (7), 636-646 (2014).</li><li>Butlin, M., Ahmad, Q. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Large+artery+stiffness+assessment+using+SphygmoCor+technology.">Large artery stiffness assessment using SphygmoCor technology.</a> Pulse. 4 (4), 180-192 (2017).</li><li>Choi, J., Kim, S. Y., Joo, S. J., Kim, K. S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Augmentation+index+is+associated+with+coronary+revascularization+in+patients+with+high+Framingham+risk+scores:+A+hospital-based+observational+study.">Augmentation index is associated with coronary revascularization in patients with high Framingham risk scores: A hospital-based observational study.</a> BMC Cardiovasc Disord. 19 (15), 131 (2015).</li><li>Doupis, J., Papanas, N., Cohen, A., McFarlan, L., Horton, E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Pulse+wave+analysis+by+applanation+tonometry+for+the+measurement+of+arterial+stiffness.">Pulse wave analysis by applanation tonometry for the measurement of arterial stiffness.</a> Open Cardiovasc Med J. 10, 188-195 (2016).</li><li>Saugel, B., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Cardiac+output+estimation+using+pulse+wave+analysis-physiology,+algorithms,+and+technologies:+A+narrative+review.">Cardiac output estimation using pulse wave analysis-physiology, algorithms, and technologies: A narrative review.</a> Br J Anaesth. 126 (1), 67-76 (2021).</li><li>Grillo, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Short-term+repeatability+of+non-invasive+aortic+pulse+wave+velocity+assessment:+comparison+between+methods+and+devices.">Short-term repeatability of non-invasive aortic pulse wave velocity assessment: comparison between methods and devices.</a> Am J Hypertens. 31 (1), 80-88 (2017).</li><li>Salvi, P., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Non-invasive+estimation+of+aortic+stiffness+through+different+approaches.">Non-invasive estimation of aortic stiffness through different approaches.</a> Hypertension. 74 (1), 117-129 (2019).</li><li>Milan, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Current+assessment+of+pulse+wave+velocity:+Comprehensive+review+of+validation+studies.">Current assessment of pulse wave velocity: Comprehensive review of validation studies.</a> J Hypertens. 37 (8), 1547-1557 (2019).</li><li>Thijssen, D. H., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Assessment+of+flow-mediated+dilation+in+humans:+A+methodological+and+physiological+guideline.">Assessment of flow-mediated dilation in humans: A methodological and physiological guideline.</a> Am J Physiol Heart Circ Physiol. 300 (1), H2-H12 (2011).</li><li>Costa Pereira, L. M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Assessment+of+cardiometabolic+risk+factors,+physical+activity+levels,+and+quality+of+life+in+stratified+groups+up+to+10+years+after+bariatric+surgery.">Assessment of cardiometabolic risk factors, physical activity levels, and quality of life in stratified groups up to 10 years after bariatric surgery.</a> Int J Environ Res Public Health. 16 (11), 1975 (2019).</li><li>Grundy, S. M., Hansen, B., Smith, S. C., Cleeman, J. I., Kahn, R. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Clinical+management+of+metabolic+syndrome:+Report+of+the+American+Heart+Association/National+Heart,+Lung,+and+Blood+Institute/American+Diabetes+Association+conference+on+scientific+issues+related+to+management.">Clinical management of metabolic syndrome: Report of the American Heart Association/National Heart, Lung, and Blood Institute/American Diabetes Association conference on scientific issues related to management.</a> Arterioscler Thromb Vasc Biol. 24 (2), e19-e24 (2004).</li><li>Williams, R. R., Wray, R. B., Tsagaris, T. J., Kuida, H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Computer+estimation+of+stroke+volume+from+aortic+pulse+contour+in+dogs+and+humans.">Computer estimation of stroke volume from aortic pulse contour in dogs and humans.</a> Cardiology. 59 (6), 350-366 (1974).</li><li>Kouchoukos, N. T., Sheppard, L. C., McDonald, D. A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Estimation+of+stroke+volume+in+the+dog+by+a+pulse+contour+method.">Estimation of stroke volume in the dog by a pulse contour method.</a> Circ Res. 26 (5), 611-623 (1970).</li><li>Corretti, M. C., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Guidelines+for+the+ultrasound+assessment+of+endothelial-dependent+flow-mediated+vasodilation+of+the+brachial+artery:+A+report+of+the+International+Brachial+Artery+Reactivity+Task+Force.">Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force.</a> J Am Coll Cardiol. 39 (2), 257-265 (2002).</li><li>Atkinson, G., Batterham, A. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+percentage+flow-mediated+dilation+index:+A+large-sample+investigation+of+its+appropriateness,+potential+for+bias+and+causal+nexus+in+vascular+medicine.">The percentage flow-mediated dilation index: A large-sample investigation of its appropriateness, potential for bias and causal nexus in vascular medicine.</a> Vasc Med. 18 (6), 354-365 (2013).</li><li>Touboul, P. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Mannheim+carotid+intima-media+thickness+consensus+(2004-2006).">Mannheim carotid intima-media thickness consensus (2004-2006).</a> Cerebrovasc Dis. 23 (2004-2006), 75-80 (2007).</li><li>Touboul, P. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Mannheim+carotid+intima-media+thickness+and+plaque+consensus+(2004-2006-2011).">Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011).</a> Cerebrovasc Dis. 34, 290-296 (2012).</li><li>Thijssen, D. H. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Expert+consensus+and+evidence-based+recommendations+for+the+assessment+of+flow-mediated+dilation+in+humans.">Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans.</a> Eur Heart J. 40 (30), 2534-2547 (2019).</li><li>Lucas-Herald, A. K., Christian, D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Carotid+intima-media+thickness+is+associated+with+obesity+and+hypertension+in+young+people.">Carotid intima-media thickness is associated with obesity and hypertension in young people.</a> Hypertension. 79 (6), 1177-1179 (2022).</li><li>Mansiroglu, A. K., Seymen, H., Sincer, I., Gunes, Y. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Evaluation+of+endothelial+dysfunction+in+COVID-19+with+flow-mediated+dilatation.">Evaluation of endothelial dysfunction in COVID-19 with flow-mediated dilatation.</a> Arq Bras Cardiol. 119 (2), 319-325 (2022).</li><li>Sincer, I., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Association+between+serum+total+antioxidant+status+and+flow-mediated+dilation+in+patients+with+systemic+lupus+erythematosus:+an+observational+study.">Association between serum total antioxidant status and flow-mediated dilation in patients with systemic lupus erythematosus: an observational study.</a> Anatol J Cardiol. 15 (11), 913-918 (2015).</li><li>Sincer, I., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Significant+correlation+between+uric+acid+levels+and+flow-mediated+dilatation+in+patients+with+masked+hypertension.">Significant correlation between uric acid levels and flow-mediated dilatation in patients with masked hypertension.</a> Clin Exp Hypertens. 36 (5), 315-320 (2014).</li><li>Nakanishi, K., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Carotid+intima-media+thickness+and+subclinical+left+heart+dysfunction+in+the+general+population.">Carotid intima-media thickness and subclinical left heart dysfunction in the general population.</a> Atherosclerosis. 305, 42-49 (2020).</li><li>Klobu&#269;ar, I., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Associations+between+endothelial+lipase,+high-density+lipoprotein,+and+endothelial+function+differ+in+healthy+volunteers+and+metabolic+syndrome+patients.">Associations between endothelial lipase, high-density lipoprotein, and endothelial function differ in healthy volunteers and metabolic syndrome patients.</a> Int J Mol Sci. 24 (3), 2073 (2023).</li><li>Sandoo, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+association+between+functional+and+morphological+assessments+of+endothelial+function+in+patients+with+rheumatoid+arthritis:+a+cross-sectional+study.">The association between functional and morphological assessments of endothelial function in patients with rheumatoid arthritis: a cross-sectional study.</a> Arthritis Res Ther. 15 (5), R107 (2013).</li><li>Toyoda, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Relationship+between+brachial+flow-mediated+dilation+and+carotid+intima-media+thickness+in+patients+with+coronary+artery+disease.">Relationship between brachial flow-mediated dilation and carotid intima-media thickness in patients with coronary artery disease.</a> Int Angiol. 39 (5), 433-442 (2020).</li></ol>

<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>Device for measuring arterial wave reflection and Pulse Wave Analysis</td>
			<td>ATCOR</td>
			<td>SphygmoCor</td>
			<td>Analyzer of pulse wave for central pressure. It contains a brachial cuff and a femoral cuff</td>
		</tr>
		<tr>
			<td>Microplate reader for absorbance, Sunrise</td>
			<td>Tecan&#160;</td>
			<td>30190079</td>
			<td>Detection Mode: Absorbance; Wavelength Range: 340 nm - 750 nm; Filter Wavelength: 405 nm,&#160;450 nm,&#160;492 nm,&#160;620 nm; Plate Format 96 well plates</td>
		</tr>
		<tr>
			<td>Nitric oxide assay kit&#160;</td>
			<td>Abcam</td>
			<td>ab65328</td>
			<td>Nitric Oxide Assay Kit, Colorimetric, Abcam Cat. ab65328 for 96-well plates</td>
		</tr>
		<tr>
			<td>Portatil ultrasound to measure FMD</td>
			<td>Sonolife</td>
			<td>MED 36-13</td>
			<td>Ultrasonography linear transducer</td>
		</tr>
		<tr>
			<td>Software for FMD WirelessUSG</td>
			<td>SonoStarMed Technologies</td>
			<td>WirelessUSG v. 3.6.52</td>
			<td>Software used to measure artery diameter for FMD</td>
		</tr>
		<tr>
			<td>Software used to calculate vascular parameters from Waveform Analysis</td>
			<td>ATCOR</td>
			<td>SphygmoCor XCEL</td>
			<td>Software used to integrate patient profile, waveform analysis, calculation of PWA, PWV and other vascular parameters</td>
		</tr>
		<tr>
			<td>Sphygmomanometer</td>
			<td>Homecare</td>
			<td>ANEROIDE 1000</td>
			<td>100% cotton self-adjustable bracelet with hook, Adult artery indicator cuff.</td>
		</tr>
		<tr>
			<td>Ultrasound to measure CIMT</td>
			<td>Philips&#160;</td>
			<td>EPIQ7L12-3 Broadband Linear Array Transducer</td>
			<td>Linear transducer (Broadband Linear Array Transducer)</td>
		</tr>
	</tbody>
</table>

pulse-wave velocity, flow-mediated dilation, and carotid intima-media thickness to assess cardiovascular risk in population with metabolic syndrome

Obesity is a major health problem worldwide due to its associated complications, such as hypertension, dyslipidemia, liver disease, atherosclerosis, insulin resistance, and type 2 diabetes mellitus (T2DM), as well as an increased risk of cardiovascular diseases (CVD)1.
The constellation of these conditions, known as Metabolic Syndrome (MS), has been reported to be a major cause of CVD pathogenesis, which is one of the leading causes of death, accounting for up to 30% of all deaths worldwide2. Obese individuals have a higher requirement for oxygen and nutrients throughout the body due to an increased blood supply demand, leading to significant hemodynamic changes. These changes can result in decreased nitric oxide (NO) availability, increased oxidative stress, and vascular endothelial dysfunction3,4,5.
Atherosclerotic diseases are major cardiovascular conditions and represent the leading cause of death worldwide. This is a clinical manifestation of multiple possible factors, including genetic and environmental factors6. People with metabolic abnormalities, such as insulin resistance or prediabetes, have been shown to have a significantly higher prevalence and incidence of coronary atherosclerosis than healthy people. Furthermore, congested blood vessels with highly lipidic plaque have been found even before the appearance of clinical manifestations of metabolic dysfunction7,8,9,10.
Arterial stiffness, endothelial dysfunction, and atherogenesis have been described as important factors in the development of cardiovascular diseases. These processes are related to vascular aging and atherogenic plaque formation in critical vessels like coronary, carotid, or limb arteries. Translational research has evidenced that arterial stiffness, endothelial dysfunction, and atherogenesis are related to common vascular damage induced by chronic inflammation, lower NO production, and oxidative stress11,12.
Measurement of Carotid-femoral pulse-wave velocity (cfPWV) represents the gold standard method to measure arterial stiffness. cfPWV can be measured using a carotid tonometer simultaneously with a leg cuff to capture blood pressure waveforms at the carotid and femoral sites. Then, a software can perform velocity calculation by computing D/&#916;t, where D is the transit distance between carotid and femoral pulse sites, and &#916;t is the time delay from the peak ECG R-wave to the foot of the corresponding pressure waveform between the carotid and femoral waveforms. Increased stiffness of central arteries, like the aorta, causes a higher speed of the ejected pulse from the left ventricle through the arteries, as well as a faster return of the reflected pressure, with a consequent elevation of pressure during left ventricular ejection, which potentially decreases coronary artery perfusion. Therefore, cfPWV may be useful as a marker of coronary artery disease, stroke, and cardiovascular diseases13,14.
Likewise, Pulse Wave Analysis (PWA) is a non-invasive vascular parameter that assesses central pressure wave characteristics, where aortic systolic and diastolic blood pressures are the main variables. By measuring arterial stiffness and elastic compliance, PWA reflects arterial distensibility, which is closely related to cardiovascular risk. This method allows for measuring parameters like the Augmentation Index, which has the ability to predict the severity of cardiovascular and coronary artery diseases. The Augmentation Index may be described as follows: an early incident arterial wave is produced after left ventricular ejection, with a subsequent reflected wave originating from the periphery. The velocity of these waves increases according to arterial stiffness, and if the reflected wave arrives at the central aorta early, aortic systolic pressure will increase. This is known as Augmented Pressure (AP), whereas its percentage relative to Pulse Pressure is known as the Augmentation Index. PWA can be measured through the applanation tonometry method, involving a slight compression of the brachial artery so that its transmural pressure is zero. At this point, Mean Arterial Pressure can be measured. After scaling the arterial pressure waveform, the systolic part of the AP waveform is analyzed, also considering biometric and demographic data15,16,17. Particularly, the applanation tonometry method (SphygmoCor) has shown acceptable repeatability and significant correlation with invasive aortic catheterization in determining aortic PWV, as well as good agreement with the Artery Society Guidelines18,19,20.
Other vascular tests like flow-mediated dilation (FMD) and carotid intima-media thickness (CIMT) represent non-invasive techniques performed by ultrasonography with linear transducers. These assessment procedures are useful for evaluating vascular health, specifically endothelial dysfunction and subclinical atherogenesis, respectively. Both have shown prognostic ability for cardiovascular events. FMD is commonly considered a reflection of endothelium-dependent arterial function, primarily mediated by nitric oxide. It serves as a surrogate marker for vascular health and has been utilized non-invasively to compare subject groups and assess the effects of interventions on individuals21.
The aim of the present study is to describe the use of methods that yield the determination of markers reflecting early subclinical vascular aging, endothelial dysfunction, and atherogenic disease. Such information allows risk stratification among populations with obesity and different metabolic profiles. These methods might be useful to determine cardiovascular damage and prognosis, as well as to evaluate vascular and atherogenic responses to pharmacologic and non-pharmacologic interventions, particularly among populations with metabolic risk factors.

<meta charset="utf8"></head><body>Yazar Spotlight: Metabolik Sendromlu Hastaların Kardiyovasküler Profilinin Değerlendirilmesi

Metabolik Sendromlu Popülasyonda Kardiyovasküler Riski Değerlendirmek için Nabız Dalgası Hızı, Akış Aracılı Dilatasyon ve Karotis İntima-Medya Kalınlığı

Vascular aging and atherogenesis are key mechanisms promoting cardiovascular diseases, particularly in the presence of risk factors like diabetes, hypertension, and other metabolic dysfunctions, pulse wave velocity, flow-mediated dilation, and carotid intima-media thickness, evolving to arterial stiffness, endothelial dysfunction, and subclinical atherogenesis, providing highly valuable information about patients'cardiovascular profile. Using combined metals to assess vascular health, we found that patient with metabolically unhealthy obesity has lower values of flow-mediated dilation or FMD and than patient with metabolically healthy obesity. This finding provide information leading to prevention, early intervention, and reduction of cardiovascular diseases in population at risk.Determination of vascular elasticity and compliance, as well as mediators of vasodilation and atherosclerosis provide a more comprehensive evaluation of vascular health and disease leading to improve re-stratification and early intervention in the metabolic syndrome population. Our hemodynamic parameters, FMD, and CIMT represent useful diagnostic tools for evaluating cardiovascular risk. Future challenges for these methods include a combined prognostic interpretation where research is still evolving.

Pulse-wave velocity (PWV), flow-mediated dilation (FMD), and carotid intima-media thickness (CIMT) are established methods used in research and clinical ...

pulse-wave-velocity-flow-mediated-dilation-carotid-intima-media

Research

JoVE Journal

Medicine

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

384 Views.  ISSSTE. Vascular aging and atherogenesis are key mechanisms promoting cardiovascular diseases, particularly in the presence of risk factors like diabetes, hypertension, and other metabolic dysfunctions, pulse wave velocity, flow-mediated dilation, and carotid intima-media thickness, evolving to arterial stiffness, endothelial dysfunction, and subclinical atherogenesis, providing highly valuable information about patients'cardiovascular profile. Using combined metals to assess vascular health, we foun...