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01:05 min
August 11th, 2023
DOI :
10.3791/65857-v
Transcript
大脑中动脉闭塞模型被广泛用于模拟小鼠缺血性脑卒中。该模型允许研究缺血性损伤的时间进展,评估神经保护剂的有效性,并探索特定基因和通路在中风病理学中的作用,最终目的是寻找新的潜在治疗方法。MRI等神经成像技术的实施可以更好地诊断,改善结果评估,并减少每项研究中所需的动物数量。
该协议对诱导短暂性大脑中动脉闭塞的最常用技术进行了清晰而详细的解释。此外,它通过引入闭塞期间麻醉退出的精确修改来实现该技术,从而减少了长时间麻醉时间的不利影响。
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