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Please note that all translations are automatically generated. Click here for the English version.
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01:10 min
February 23rd, 2024
DOI :
10.3791/65930-v
Transcript
转录组学使我们能够深入了解细胞程序及其对外部变化的反应。然而,尽管在过去几十年中,文库生产和测序成本大幅降低,但以药物筛选所需的规模应用这项技术仍然难以承受,阻碍了这些方法的巨大潜力。我们的研究提出了一种具有成本效益的基于转录组的药物筛选系统,将小型扰动培养物与小型批量转录组学相结合。
优化的小型批量实验方案以经济高效的测序深度提供信息丰富的生物信号,从而能够对已知药物和新分子进行广泛筛选。将转录组学与无偏倚药物筛选相结合的主要好处之一是有可能识别以前未考虑过的新药物靶点。传统
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