<ol>
	<li>Lascar, N., Brown, J., Pattison, H., Barnett, A. H., Bailey, C. J., Bellary, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Type+2+diabetes+in+adolescents+and+young+adults.">Type 2 diabetes in adolescents and young adults.</a> Lancet Diabetes Endocrinol. 6 (1), 69-80 (2018).</li><li>Song, Y., Zhao, F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Bibliometric+analysis+of+metabolic+surgery+for+type+2+diabetes:+current+status+and+future+prospects.">Bibliometric analysis of metabolic surgery for type 2 diabetes: current status and future prospects.</a> Updates Surg. 74 (2), 697-707 (2022).</li><li>Cummings, D. E., Rubino, F. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Metabolic+surgery+for+the+treatment+of+type+2+diabetes+in+obese+individuals.">Metabolic surgery for the treatment of type 2 diabetes in obese individuals.</a> Diabetologia. 61 (2), 257-264 (2018).</li><li>Buchwald, H. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+evolution+of+metabolic/bariatric+surgery.">The evolution of metabolic/bariatric surgery.</a> Obes Surg. 24 (8), 1126-1135 (2014).</li><li>Akalestou, E., Miras, A. D., Rutter, G. A., le Roux, C. W. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Mechanisms+of+weight+loss+after+obesity+surgery.">Mechanisms of weight loss after obesity surgery.</a> Endocr Rev. 43 (1), 19-34 (2022).</li><li>Rubino, F., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+mechanism+of+diabetes+control+after+gastrointestinal+bypass+surgery+reveals+a+role+of+the+proximal+small+intestine+in+the+pathophysiology+of+type+2+diabetes.">The mechanism of diabetes control after gastrointestinal bypass surgery reveals a role of the proximal small intestine in the pathophysiology of type 2 diabetes.</a> Ann Surg. 244 (5), 741-749 (2006).</li><li>Rubino, F., Marescaux, J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Effect+of+duodenal-jejunal+exclusion+in+a+non-obese+animal+model+of+type+2+diabetes:+a+new+perspective+for+an+old+disease.">Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease.</a> Ann Surg. 239 (1), 1-11 (2004).</li><li>Akalestou, E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Establishing+a+successful+rat+model+of+duodenal-+jejunal+bypass:+A+detailed+guide.">Establishing a successful rat model of duodenal- jejunal bypass: A detailed guide.</a> Lab Anim. 53 (4), 362-371 (2019).</li><li>Yu, H. H., Hsieh, M. C., Wu, S. Y., Sy, E. D., Shan, Y. S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Effects+of+duodenal-jejunal+bypass+surgery+in+ameliorating+nonalcoholic+steatohepatitis+in+diet-induced+obese+rats.">Effects of duodenal-jejunal bypass surgery in ameliorating nonalcoholic steatohepatitis in diet-induced obese rats.</a> Diabetes Metab Syndr Obes. 12, 149-159 (2019).</li><li>Garciacaballero, M., Navarrete, S., Favretti, F., Celik, A., Del Castillo, D. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Diabetes+surgery+in+type+2+BMI+24-29+vs+IMC+30-34+diabetic+patients:+is+there+differences+among+restrictive,+malabsorptive+and+gastric+bypass+procedures.">Diabetes surgery in type 2 BMI 24-29 vs IMC 30-34 diabetic patients: is there differences among restrictive, malabsorptive and gastric bypass procedures.</a> Nutr Hosp. 28 (2), 23-30 (2013).</li><li>Vidal, J., Jim&#233;nez, A. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Diabetes+remission+following+metabolic+surgery:+is+GLP-1+the+culprit.">Diabetes remission following metabolic surgery: is GLP-1 the culprit.</a> Curr Atheroscler Rep. 15 (10), 357 (2013).</li><li>Speck, M., Cho, Y. M., Asadi, A., Rubino, F., Kieffer, T. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Duodenal-jejunal+bypass+protects+GK+rats+from+{beta}-cell+loss+and+aggravation+of+hyperglycemia+and+increases+enteroendocrine+cells+coexpressing+GIP+and+GLP-1.">Duodenal-jejunal bypass protects GK rats from {beta}-cell loss and aggravation of hyperglycemia and increases enteroendocrine cells coexpressing GIP and GLP-1.</a> Am J Physiol Endocrinol Metab. 300 (5), E923-E932 (2011).</li><li>Ashrafian, H., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Metabolic+surgery:+an+evolution+through+bariatric+animal+models.">Metabolic surgery: an evolution through bariatric animal models.</a> Obes Rev. 11 (12), 907-920 (2010).</li><li>Rao, R. S., Rao, V., Kini, S. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Animal+models+in+bariatric+surgery--a+review+of+the+surgical+techniques+and+postsurgical+physiology.">Animal models in bariatric surgery--a review of the surgical techniques and postsurgical physiology.</a> Obes Surg. 20 (9), 1293-1305 (2010).</li><li>Im, Y. R., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+systematic+review+of+animal+models+of+NAFLD+finds+high-fat,+high-fructose+diets+most+closely+resemble+human+NAFLD.">A systematic review of animal models of NAFLD finds high-fat, high-fructose diets most closely resemble human NAFLD.</a> Hepatology. 74 (4), 1884-1901 (2021).</li><li>Kleinert, M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Animal+models+of+obesity+and+diabetes+mellitus.">Animal models of obesity and diabetes mellitus.</a> Nat Rev Endocrinol. 14 (3), 140-162 (2018).</li><li>Furman, B. L. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Streptozotocin-induced+diabetic+models+in+mice+and+rats.">Streptozotocin-induced diabetic models in mice and rats.</a> Curr Protoc. 1 (4), e78 (2021).</li><li>Buchwald, H., Varco, R. L., Moore, R. B., Schwartz, M. Z. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Intestinal+bypass+procedures.+Partial+ileal+bypass+for+hyperlipidemia+and+jejunoileal+bypass+for+obesity.">Intestinal bypass procedures. Partial ileal bypass for hyperlipidemia and jejunoileal bypass for obesity.</a> Curr Probl Surg. , 1-51 (1975).</li><li>DeMaria, E. J. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Bariatric+surgery+for+morbid+obesity.">Bariatric surgery for morbid obesity.</a> N Engl J Med. 356 (21), 2176-2183 (2007).</li><li>Bolling, C. F., Armstrong, S. C., Reichard, K. W., Michalsky, M. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Metabolic+and+bariatric+surgery+for+pediatric+patients+with+severe+obesity.">Metabolic and bariatric surgery for pediatric patients with severe obesity.</a> Pediatrics. 144 (6), e20193224 (2019).</li><li>Mason, E. E. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Gastric+bypass+for+morbid+obesity.">Gastric bypass for morbid obesity.</a> Surg Annu. 11, 99-126 (1979).</li><li>Cheng, Y., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Sleeve+gastrectomy+with+bypass+of+proximal+small+intestine+provides+better+diabetes+control+than+sleeve+gastrectomy+alone+under+postoperative+high-fat+diet.">Sleeve gastrectomy with bypass of proximal small intestine provides better diabetes control than sleeve gastrectomy alone under postoperative high-fat diet.</a> Obes Surg. 29 (1), 84-92 (2019).</li><li>Rubino, F., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=The+role+of+the+small+bowel+in+the+regulation+of+circulating+ghrelin+levels+and+food+intake+in+the+obese+Zucker+rat.">The role of the small bowel in the regulation of circulating ghrelin levels and food intake in the obese Zucker rat.</a> Endocrinology. 146 (4), 1745-1751 (2005).</li><li>Zachariah, P. J., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Compared+to+sleeve+gastrectomy,+duodenal-jejunal+bypass+with+sleeve+gastrectomy+gives+better+glycemic+control+in+T2DM+patients,+with+a+lower+&#946;-cell+response+and+similar+appetite+sensations:+mixed-meal+study.">Compared to sleeve gastrectomy, duodenal-jejunal bypass with sleeve gastrectomy gives better glycemic control in T2DM patients, with a lower &#946;-cell response and similar appetite sensations: mixed-meal study.</a> Obes Surg. 26 (12), 2862-2872 (2016).</li><li>Jiang, B., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Role+of+proximal+intestinal+glucose+sensing+and+metabolism+in+the+blood+glucose+control+in+type+2+diabetic+rats+after+duodenal+jejunal+bypass+surgery.">Role of proximal intestinal glucose sensing and metabolism in the blood glucose control in type 2 diabetic rats after duodenal jejunal bypass surgery.</a> Obes Surg. 32 (4), 1119-1129 (2022).</li><li>Han, H. F., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Duodenal-jejunal+bypass+increases+intraduodenal+bile+acids+and+upregulates+duodenal+SIRT1+expression+in+high-fat+diet+and+streptozotocin-induced+diabetic+rats.">Duodenal-jejunal bypass increases intraduodenal bile acids and upregulates duodenal SIRT1 expression in high-fat diet and streptozotocin-induced diabetic rats.</a> World J Gastroenterol. 28 (31), 4338-4350 (2022).</li><li>Yan, S., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Reduction+of+intestinal+electrogenic+glucose+absorption+after+duodenojejunal+bypass+in+a+mouse+model.">Reduction of intestinal electrogenic glucose absorption after duodenojejunal bypass in a mouse model.</a> Obes Surg. 23 (9), 1361-1369 (2013).</li><li>Arble, D. M., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Metabolic+comparison+of+one-anastomosis+gastric+bypass,+single-anastomosis+duodenal-switch,+Roux-en-Y+gastric+bypass,+and+vertical+sleeve+gastrectomy+in+rat.">Metabolic comparison of one-anastomosis gastric bypass, single-anastomosis duodenal-switch, Roux-en-Y gastric bypass, and vertical sleeve gastrectomy in rat.</a> Surg Obes Relat Dis. 14 (12), 1857-1867 (2018).</li><li>Liang, Y., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Duodenal-jejunal+bypass+surgery+reverses+diabetic+phenotype+and+reduces+obesity+in+db/db+Mice.">Duodenal-jejunal bypass surgery reverses diabetic phenotype and reduces obesity in db/db Mice.</a> Curr Chem Genom Transl Med. 11, 41-49 (2017).</li><li>Barataud, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Absence+of+role+of+dietary+protein+sensing+in+the+metabolic+benefits+of+duodenal-jejunal+bypass+in+the+mouse.">Absence of role of dietary protein sensing in the metabolic benefits of duodenal-jejunal bypass in the mouse.</a> Sci Rep. 7, 44856 (2017).</li><li>. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Close-up+on+lab+animal+microsurgery.">Close-up on lab animal microsurgery.</a> Lab Anim (NY). 35 (1), 43 (2006).</li><li>Couceiro, J., Castro, R., Tien, H., Ozyurekoglu, T. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Step+by+step:+microsurgical+training+method+combining+two+nonliving+animal+models.">Step by step: microsurgical training method combining two nonliving animal models.</a> J Vis Exp. 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<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>Abdominal retractor</td>
			<td>F.S.T</td>
			<td>17000-03</td>
			<td>Colibri Retractor -3cm,retractor range 1.5cm/3cm long</td>
		</tr>
		<tr>
			<td>1% sodium pentobarbital solution</td>
			<td>Guangzhou Chemical Reagent Factory</td>
			<td>/</td>
			<td>&#160;Dissolved 500mg of pentobarbital sodium powder in 50ml of normal saline to obtain 1% pentobarbital sodium solution.</td>
		</tr>
		<tr>
			<td>Benzylpenicillin sodium for Injection</td>
			<td>North China Pharmaceutical Company Ltd.</td>
			<td>F2062121</td>
			<td>Penicillin</td>
		</tr>
		<tr>
			<td>Buprenorphine</td>
			<td>Guangzhou Chemical Reagent Factory</td>
			<td>/</td>
			<td>Analgesia</td>
		</tr>
		<tr>
			<td>Buprenorphine</td>
			<td>Guangzhou Otsuka Pharmaceutical Co., Ltd</td>
			<td>/</td>
			<td>Analgesic</td>
		</tr>
		<tr>
			<td>Citric acid-sodium citrate buffer</td>
			<td>LEAGENE</td>
			<td>R00522</td>
			<td>Buffer solution</td>
		</tr>
		<tr>
			<td>Cotton buds</td>
			<td>HaoZheng Medical</td>
			<td>60220610</td>
			<td>Cotton swabs</td>
		</tr>
		<tr>
			<td>Depilatory paste</td>
			<td>Veet</td>
			<td>AAPR-S222</td>
			<td>Hair removal cream</td>
		</tr>
		<tr>
			<td>Ear tag</td>
			<td>ZEYA</td>
			<td>SUS304</td>
			<td>Ear-mark</td>
		</tr>
		<tr>
			<td>Electric blanket</td>
			<td>ZOSEN</td>
			<td>ZS-CWDRT</td>
			<td>Heat pad</td>
		</tr>
		<tr>
			<td>Electronic scale</td>
			<td>WETTLER TOLEDO</td>
			<td>20060902-6</td>
			<td>Measure the weight</td>
		</tr>
		<tr>
			<td>Enteral nutritional powder</td>
			<td>Abbott Laboratories</td>
			<td>/</td>
			<td>Nutrition powder</td>
		</tr>
		<tr>
			<td>Eye ointment</td>
			<td>Guangzhou Otsuka Pharmaceutical Co., Ltd</td>
			<td>/</td>
			<td>Protect the eyes</td>
		</tr>
		<tr>
			<td>Glucometer</td>
			<td>Roche</td>
			<td>6993788001</td>
			<td>Assess blood glucose</td>
		</tr>
		<tr>
			<td>Graphpad Prism version 9.4.1</td>
			<td>GraphPad Software</td>
			<td>version 9.4.1</td>
			<td>Software for statistical analysis</td>
		</tr>
		<tr>
			<td>High-fat diet (High Fat [60FDC] Purified Rodent Diet)</td>
			<td>Dyets</td>
			<td>112252</td>
			<td>60kcal% High Fat Diet</td>
		</tr>
		<tr>
			<td>Micro Forceps</td>
			<td>Jinzhong Medical</td>
			<td>18-1140</td>
			<td>Micro forceps</td>
		</tr>
		<tr>
			<td>Micro needle holder</td>
			<td>Jinzhong Medical</td>
			<td>EMT-160-Z</td>
			<td>Needle holder</td>
		</tr>
		<tr>
			<td>Micro Scissors</td>
			<td>Jinzhong Medical</td>
			<td>YBC010</td>
			<td>Micro scissors</td>
		</tr>
		<tr>
			<td>Microscope camera</td>
			<td>LAPSUN</td>
			<td>E 2000</td>
			<td>Video</td>
		</tr>
		<tr>
			<td>Ophthalmic scissors</td>
			<td>Jinzhong Medical</td>
			<td>Y00030</td>
			<td>Surgical scissors</td>
		</tr>
		<tr>
			<td>Pentobarbital</td>
			<td>Guangzhou Chemical Reagent Factory</td>
			<td>/</td>
			<td>Narcosis</td>
		</tr>
		<tr>
			<td>Sodium chloride Injection</td>
			<td>Guangzhou Otsuka Pharmaceutical Co., Ltd</td>
			<td>B21L0301</td>
			<td>NaCl 0.9%</td>
		</tr>
		<tr>
			<td>Stereo microscope</td>
			<td>ZEISS</td>
			<td>Stemi 305</td>
			<td>Binocular stereomicroscope</td>
		</tr>
		<tr>
			<td>Streptozotocin</td>
			<td>Sigma</td>
			<td>S110910-1g</td>
			<td>STZ</td>
		</tr>
		<tr>
			<td>Suture line</td>
			<td>LINGQIAO SUTURE</td>
			<td>ZS-LQPMRZ5/0</td>
			<td>Prolene 6/0,Prolene 10/0</td>
		</tr>
		<tr>
			<td>Tissue forceps</td>
			<td>Jinzhong Medical</td>
			<td>H1701</td>
			<td>Surgical forceps</td>
		</tr>
	</tbody>
</table>

duodenal-jejunal bypass surgery in diet-induced obese diabetic mice

Duodenal-Jejunal bypass-kirurgi hos dietinducerade överviktiga diabetiska möss

The prevalence of obesity and type 2 diabetes is a serious global health concern. Obesity is a major pathogenic factor in type 2 diabetes, cardiovascular ...

duodenal-jejunal-bypass-surgery-in-diet-induced-obese-diabetic-mice

Research

JoVE Journal

Medicine

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice

295 Views.  Jinshazhou Hospital of Guangzhou University of Chinese Medicine. The increasing instance of obesity and Type 2 Diabetes has become a serious health problem. Duodenal-jejunal bypass surgery, DJB, can improve glucose metabolism and ameliorate insulin resistance. And its metabolic benefits independent of weight loss are not fully understood.Diet-induced obese diabetical mice were selected for DJB surgery to determine the feasibility and vertical structure of the surgery and to provide technicals for subsequent research. Mice were injected intraperitone...