Our research focuses on the detailed surgical procedures of calvarial suture-bony composite defects in rats alongside the investigations into the short-term and long-term prognoses of the model. The primary objective is to establish a standardized model that can be utilized for advancing suture regenerative therapies. For the current animal model, the primary challenge lies in completely removing the coronal suture while preserving the sagittal and frontal sutures with minimal osseous tissue removal.
Our protocol allows for more straightforward comparation through self-control by creating defects in both the left and the right halves of the coronal suture and applying different interventions to each side.
