<meta charset="utf8"></head><body>Synthese van ionische vloeistoffen op basis van chinoline voor antimicrobiële toepassingen

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V., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Applications+of+ionic+liquids+in+electrochemical+sensors+and+biosensors.">Applications of ionic liquids in electrochemical sensors and biosensors.</a> Int J Electrochem. 2012 (9), 112-125 (2012).</li><li>Must, I., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Ionic+liquid-based+actuators+working+in+air:+The+effect+of+ambient+humidity.">Ionic liquid-based actuators working in air: The effect of ambient humidity.</a> Sens Actuat B: Chemical. 202 (3), 114-122 (2014).</li><li>Ray, A., Saruhan, B. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Application+of+ionic+liquids+for+batteries+and+supercapacitors.">Application of ionic liquids for batteries and supercapacitors.</a> Materials. 14 (11), 2942 (2021).</li><li>Alashkar, A., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=A+critical+review+on+the+use+of+ionic+liquids+in+proton+exchange+membrane+fuel+cells.">A critical review on the use of ionic liquids in proton exchange membrane fuel cells.</a> Membranes. 12 (2), 178 (2022).</li><li>Busetti, A., Crawford, R. J., Ivanova, E. P. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Antimicrobial+and+antibiofilm+activities+of+1-alkylquinolinium+bromide+ionic+liquids.">Antimicrobial and antibiofilm activities of 1-alkylquinolinium bromide ionic liquids.</a> Green Chem. 12 (3), 420-425 (2010).</li><li>Sharma, K., Sharma, M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=In+vitro+anti-biofilm+activity+and+the+artificial+chaperone+activity+of+quinoline-based+ionic+liquids.">In vitro anti-biofilm activity and the artificial chaperone activity of quinoline-based ionic liquids.</a> Colloids Surfaces B: Biointer. 235, 113773 (2024).</li><li>Qashou, E., et al. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Antiproliferative+activities+of+lipophilic+fluoroquinolones-based+scaffold+against+a+panel+of+solid+and+liquid+cancer+cell+lines.">Antiproliferative activities of lipophilic fluoroquinolones-based scaffold against a panel of solid and liquid cancer cell lines.</a> Asian Paci J Cancer Prevent. 23 (5), 1529-1538 (2022).</li><li>Patel, H. M. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=Synthesis+of+new+mannich+products+bearing+quinoline+nucleus+using+reusable+ionic+liquid+and+antitubercular+evaluation.">Synthesis of new mannich products bearing quinoline nucleus using reusable ionic liquid and antitubercular evaluation.</a> Green Sust Chem. 5 (4), 137-144 (2015).</li><li>Joshi, D. R., Adhikari, N. <a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Search&doptcmdl=Citation&defaultField=Title+Word&term=An+overview+on+common+organic+solvents+and+their+toxicity.">An overview on common organic solvents and their toxicity.</a> J Pharm Res Int. 28 (3), 1-18 (2019).</li><li>Sanchez, J. 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<table border="1" fo:keep-together.within-page="1" fo:keep-with-next.within-page="always">
	<tbody>
		<tr>
			<td>1-bromohexadecane</td>
			<td>Merck</td>
			<td>CAS no.112-82-3</td>
			<td>95% pure (as determined by HPLC analysis)</td>
		</tr>
		<tr>
			<td>Ethyl acetate</td>
			<td>Merck</td>
			<td>CAS no. 205-500-4</td>
			<td>95% pure (as determined by HPLC analysis)</td>
		</tr>
		<tr>
			<td>Nuclear Magnetic Resonance (NMR) spectrometer</td>
			<td>Jeol, Model: JNM-ECZ 400S</td>
			<td>Nil</td>
			<td>Nil</td>
		</tr>
		<tr>
			<td>Quinoline</td>
			<td>Merck</td>
			<td>CAS no.91-22-5</td>
			<td>95% pure (as determined by HPLC analysis)</td>
		</tr>
		<tr>
			<td>Toluene</td>
			<td>Merck</td>
			<td>CAS no. 108-88-3</td>
			<td>95% pure (as determined by HPLC analysis)</td>
		</tr>
	</tbody>
</table>

green synthesis of quinoline-based ionic liquid

The monumental growth in the world population accounts for a tremendous increment in the consumption of a vast array of commodities over the past few years, including food, medicaments, as well as other crucial products for the sustenance of mortal organisms. This has invigorated the quest for novel chemical compounds with exceptionally specialized, ecologically sound, and beneficial properties worldwide. Ionic Liquids (ILs) have proved to be felicitous in this regard. The implication of these compounds in the scientific domain has bolstered new ventures in research in contemporary chemical technologies1. In contrast to the conventional approaches, the utilization of ILs not only facilitates progressive reaction conditions but also promotes a customized strategy to get to grips with various biochemical challenges related to experimental research and development2.
Typically, ILs are stable salts constituting cations (organic) and anions (inorganic), possessing a melting point below 100 &#176;C3. Abiding by the 12 principles of green chemistry, empirically, these are convincing substitutes to the customary organic solvents4. The astounding properties associated with the utilization of these compounds encompass great intrinsic conductivity, polarity, solvating tendency, thermal stability, non-volatility, acidity/basicity, hydrophilicity/ hydrophobicity, and tunability, making ILs best suited for experimental research5.
Apart from the expansive applications of various classes of ILs in modern organic synthesis6, catalysis7, and various electrochemical processes involving sensors8, actuators9, batteries10, and fuel cells11, over the past few years, this class of compounds has been given momentous recognition in the field of biomedicine in light of AMR. Current probations reveal that ILs based on imidazolium, pyridine, choline, and pyrrole are extremely effective as therapeutic agents owing to their high charge and hydrophobicity12. However, quinoline-based counterparts are still considered to be most potent against the pathogenic microbes12. Additional biomedical applications accompanying this class of ILs include artificial chaperone activity13, cytotoxicity against cancerous cells14 as well as an excellent drug-carrying capacity15.
Conventionally, the fabrication of ILs involves the utilization of highly toxic solvent mediums such as dichloromethane, benzene, carbon tetrachloride, dichloroethylene, etc.16, hindering the biocompatibility and elevating the toxicity of the compound, making them undesirable for biological use. Additionally, the use of harmful solvents in the reaction media not only slows down the reaction time but also increases the unintentional production of waste byproducts released into the environment17. Moreover, the dissolvent used in the reaction media also influences the pH of the final product; hence, its removal at the end of the reaction is vital, especially when the desired compound is intended to be used for protein-related biological systems. Hence, keeping away from the usage of such solvent is favorable in the realm of green chemistry.
In this study, we report the one-pot synthesis of a biocompatible and non-toxic13 IL, namely, 1-Hexadecylquinolin-1-ium bromide, using a greener route. The present strategy omits the utilization of a molecular solvent, leveraging the self-solvating ability of the IL formed within the reaction mixture, promoting high reaction efficiency and chemical yield. Menschutkin reaction18forms the basis of the&#160;current synthesis methodology. The purity of the synthesized compound is probed using NMR and IR spectroscopy. The pharmacokinetic profile of the compound and toxicity were investigated through the ADMET studies. Furthermore, the antimicrobial potential of the synthesized IL against the pathogenic Candida albicans strain has also been demonstrated in the study.

<meta charset="utf8"></head><body>Auteur in de schijnwerpers: onderzoek naar antimicrobiële resistentie bevorderen met innovatieve benaderingen en synthetische verbindingen

Groene synthese van ionische vloeistof op basis van chinoline

Antimicrobial resistance is a complex global health threat that requires a multifaceted research approach. AMR research aims to better understand the phenomena, develop effective interventions, and mitigate the global health threat posed by antimicrobial resistance. The field of AMR has seen significant advancements in recent years with researchers exploring innovative approaches to combat the growing global health threat.Research is being done to develop antibiotic therapies, alternative approaches, improve diagnostics, infection preventions, et cetera. A variety of technologies are being employed to x-ray, research and development in the field of AMR, such as genomics and bioinformatics, nanotechnology for drug delivery and biosensors, artificial intelligence and machine learning to analyze data and patterns related to AMR. We're currently working on reducing the reaction time and optimizing the speed of the reaction under desired conditions, keeping the purity of the product our topmost priority.Over the years, a large number of synthetic compounds have been fabricated with the potential to be utilized as antimicrobial agents. However, their synthesis involves the use of several harmful chemical solvents imparting their own potency over the test organisms, enhancing their toxicity and limiting their applications in the field of biomedical chemistry.

The ever-growing menace of Antimicrobial Resistance (AMR) jeopardizes the potency of the prevailing antibiotics against the relentlessly sprouting ...

green-synthesis-of-quinoline-based-ionic-liquid

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JoVE Journal

Chemistry

Green Synthesis of Quinoline-Based Ionic Liquid

604 Views.  University of Delhi. Antimicrobial resistance is a complex global health threat that requires a multifaceted research approach. AMR research aims to better understand the phenomena, develop effective interventions, and mitigate the global health threat posed by antimicrobial resistance. The field of AMR has seen significant advancements in recent years with researchers exploring innovative approaches to combat the growing global health threat.Research is being done to develop antibiotic therapies, alternat...