Chien-Kuo Lee

What does Stat3 do?

STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation.

Tissue-specific positive feedback requirements for production of type I interferon following virus infection.

Stat1 and Stat2 but not Stat3 arbitrate contradictory growth signals elicited by alpha/beta interferon in T lymphocytes.

STAT3 positively regulates an early step in B-cell development.

Tie2-R849W mutant in venous malformations chronically activates a functional STAT1 to modulate gene expression.

CLEC5A is critical for dengue-virus-induced lethal disease.

STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response.

Suppressor of cytokine signaling and accelerated atherosclerosis in kidney disease.

STAT3 negatively regulates type I IFN-mediated antiviral response.

Intrahepatic infiltrating NK and CD8 T cells cause liver cell death in different phases of dengue virus infection.

A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors.

Immunodeficient mouse models with different disease profiles by in vivo infection with the same clinical isolate of enterovirus 71.

The pathological effects of CCR2+ inflammatory monocytes are amplified by an IFNAR1-triggered chemokine feedback loop in highly pathogenic influenza infection.

STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1.

Effects of RING-SH2Grb², a chimeric protein containing the E3 ligase domain of Cbl, on the EGFR pathway.

An alternatively spliced IL-15 isoform modulates abrasion-induced keratinocyte activation.

Efficient Generation of Plasmacytoid Dendritic Cell from Common Lymphoid Progenitors by Flt3 Ligand.

STAT1 regulates marginal zone B cell differentiation in response to inflammation and infection with blood-borne bacteria.

Antibodies against nonstructural protein 1 protect mice from dengue virus-induced mast cell activation.

Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages.

Therapeutic Effects of Monoclonal Antibody against Dengue Virus NS1 in a STAT1 Knockout Mouse Model of Dengue Infection.

Signal Integration of IFN-I and IFN-II With TLR4 Involves Sequential Recruitment of STAT1-Complexes and NFκB to Enhance Pro-inflammatory Transcription.

Fine-Tuning of Type I Interferon Response by STAT3.

Editorial: STATs and IRFs in Innate Immunity: From Transcriptional Regulators to Therapeutic Targets.