Howard L. Weiner
Center for Neurologic Diseases,
Brigham and Women's Hospital,
Center for Neurologic Diseases, Brigham and Women's Hospital
Harvard Medical School
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Oral tolerance, an active immunologic process mediated by multiple mechanisms.
The Journal of clinical investigation Oct, 2000 | Pubmed ID: 11032852
CNS drugs , 2002 | Pubmed ID: 11772115
International immunology Feb, 2002 | Pubmed ID: 11809732
Journal of magnetic resonance imaging : JMRI Feb, 2002 | Pubmed ID: 11836778
Neurosurgery Apr, 2002 | Pubmed ID: 11904022
European journal of immunology Apr, 2002 | Pubmed ID: 11920578
Journal of neuroimmunology Apr, 2002 | Pubmed ID: 11960649
Plastic and reconstructive surgery May, 2002 | Pubmed ID: 11994607
Journal of neuroimmunology May, 2002 | Pubmed ID: 12020972
Clinical immunology (Orlando, Fla.) May, 2002 | Pubmed ID: 12027417
Nature medicine Jun, 2006 | Pubmed ID: 16715091
Cutting edge: oral type I IFN-tau promotes a Th2 bias and enhances suppression of autoimmune encephalomyelitis by oral glatiramer acetate.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2002 | Pubmed ID: 12193686
Circulation Sep, 2002 | Pubmed ID: 12270867
Cancer research Nov, 2002 | Pubmed ID: 12438220
The American journal of pathology Dec, 2002 | Pubmed ID: 12466141
Nature Dec 19-26, 2002 | Pubmed ID: 12490962
Journal of child neurology Sep, 2002 | Pubmed ID: 12503646
Induction of low dose oral tolerance in monocyte chemoattractant protein-1- and CCR2-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2003 | Pubmed ID: 12594253
Journal of immunology (Baltimore, Md. : 1950) Mar, 2003 | Pubmed ID: 12594277
Neurology Feb, 2003 | Pubmed ID: 12601106
Journal of autoimmunity Mar, 2003 | Pubmed ID: 12657527
FASEB journal : official publication of the Federation of American Societies for Experimental Biology May, 2003 | Pubmed ID: 12724345
Markers of cellular proliferation are expressed in cortical tubers.
Annals of neurology May, 2003 | Pubmed ID: 12731003
Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis.
The Journal of experimental medicine May, 2003 | Pubmed ID: 12732654
Journal of pediatric hematology/oncology May, 2003 | Pubmed ID: 12759623
Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease.
The Journal of clinical investigation Aug, 2003 | Pubmed ID: 12897209
Journal of immunology (Baltimore, Md. : 1950) Sep, 2003 | Pubmed ID: 12928365
Journal of autoimmunity Sep, 2003 | Pubmed ID: 12935782
Science (New York, N.Y.) Oct, 2003 | Pubmed ID: 14593170
Journal of immunology (Baltimore, Md. : 1950) Dec, 2003 | Pubmed ID: 14662856
IFN-inducible protein 10/CXC chemokine ligand 10-independent induction of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2004 | Pubmed ID: 14688366
Journal of neuroimmunology Jan, 2004 | Pubmed ID: 14698862
Immunologic research , 2003 | Pubmed ID: 14713719
International immunology Feb, 2004 | Pubmed ID: 14734610
Pediatric clinics of North America Apr, 2004 | Pubmed ID: 15062675
The Journal of experimental medicine Apr, 2004 | Pubmed ID: 15067033
Journal of neuroimaging : official journal of the American Society of Neuroimaging Jul, 2004 | Pubmed ID: 15228759
Journal of the neurological sciences Aug, 2004 | Pubmed ID: 15261554
Epilepsia , 2004 | Pubmed ID: 15281957
Archives of neurology Oct, 2004 | Pubmed ID: 15477521
Induction of low dose oral tolerance in IL-10 deficient mice with experimental autoimmune encephalomyelitis.
Journal of autoimmunity Nov, 2004 | Pubmed ID: 15501390
Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease.
Journal of Alzheimer's disease : JAD Oct, 2004 | Pubmed ID: 15505369
Journal of child neurology Sep, 2004 | Pubmed ID: 15563015
Cellular immunology Aug, 2004 | Pubmed ID: 15598424
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Dec, 2004 | Pubmed ID: 15611503
Neurologic clinics Feb, 2005 | Pubmed ID: 15661097
Neurosurgery Feb, 2005 | Pubmed ID: 15670380
Annals of the New York Academy of Sciences Dec, 2004 | Pubmed ID: 15681760
Archives of neurology May, 2005 | Pubmed ID: 15883268
Journal of neuroimmunology Jun, 2005 | Pubmed ID: 15885317
Journal of the neurological sciences Jun, 2005 | Pubmed ID: 15894335
Journal of neurosurgery Jun, 2005 | Pubmed ID: 16028775
Immunological reviews Aug, 2005 | Pubmed ID: 16048553
The Journal of clinical investigation Sep, 2005 | Pubmed ID: 16100572
The ICOS molecule plays a crucial role in the development of mucosal tolerance.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2005 | Pubmed ID: 16301640
Epileptic disorders : international epilepsy journal with videotape Dec, 2005 | Pubmed ID: 16338674
Neurosurgical focus Nov, 2005 | Pubmed ID: 16398472
Journal of autoimmunity Mar, 2006 | Pubmed ID: 16426816
Induction of oral tolerization in CD86 deficient mice: a role for CD86 and B cells in the up-regulation of TGF-beta.
Journal of autoimmunity Mar, 2006 | Pubmed ID: 16439314
Neurosurgical focus , 2006 | Pubmed ID: 16459994
Journal of neuroimmunology May, 2006 | Pubmed ID: 16533538
International immunology Apr, 2006 | Pubmed ID: 16540527
Proceedings of the National Academy of Sciences of the United States of America Mar, 2006 | Pubmed ID: 16549802
Annals of neurology May, 2006 | Pubmed ID: 16634007
Nature reviews. Immunology May, 2006 | Pubmed ID: 16639431
Nature May, 2006 | Pubmed ID: 16648838
Pediatrics May, 2006 | Pubmed ID: 16651302
Journal of immunology (Baltimore, Md. : 1950) Jun, 2006 | Pubmed ID: 16751425
Journal of neuroimmunology Aug, 2006 | Pubmed ID: 16806500
Journal of immunology (Baltimore, Md. : 1950) Aug, 2006 | Pubmed ID: 16887994
Inflammation & allergy drug targets Sep, 2006 | Pubmed ID: 16918481
Journal of immunology (Baltimore, Md. : 1950) Sep, 2006 | Pubmed ID: 16951385
A model for the comprehensive investigation of a chronic autoimmune disease: the multiple sclerosis CLIMB study.
Autoimmunity reviews Oct, 2006 | Pubmed ID: 17027888
Clinical & developmental immunology Jun-Dec, 2006 | Pubmed ID: 17162357
Journal of immunology (Baltimore, Md. : 1950) Jan, 2007 | Pubmed ID: 17182552
Journal of immunology (Baltimore, Md. : 1950) Jan, 2007 | Pubmed ID: 17182553
Cutting Edge: Immature human dendritic cells express latency-associated peptide and inhibit T cell activation in a TGF-beta-dependent manner.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2007 | Pubmed ID: 17371954
Natalizumab treatment for multiple sclerosis: recommendations for patient selection and monitoring.
Lancet neurology May, 2007 | Pubmed ID: 17434098
Diabetes Aug, 2007 | Pubmed ID: 17456848
Epilepsia Aug, 2007 | Pubmed ID: 17484758
Journal of the neurological sciences Aug, 2007 | Pubmed ID: 17521671
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics Jul, 2007 | Pubmed ID: 17599713
Epilepsy & behavior : E&B Aug, 2007 | Pubmed ID: 17613275
What does the future hold for cell-based tolerogenic therapy?
Nature reviews. Immunology Aug, 2007 | Pubmed ID: 17653127
Neurosurgery Aug, 2007 | Pubmed ID: 17762730
Nature immunology Dec, 2007 | Pubmed ID: 17994022
Journal of autoimmunity Feb-Mar, 2008 | Pubmed ID: 18191540
Epilepsia , 2008 | Pubmed ID: 18226172
Nature biotechnology Feb, 2008 | Pubmed ID: 18259174
Journal of neurology Mar, 2008 | Pubmed ID: 18317671
The Journal of clinical investigation Apr, 2008 | Pubmed ID: 18340379
Annals of neurology May, 2008 | Pubmed ID: 18360829
Nature May, 2008 | Pubmed ID: 18362915
Journal of neuroimmunology Mar, 2008 | Pubmed ID: 18378324
Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis.
Journal of neuroimmunology Mar, 2008 | Pubmed ID: 18403025
Journal of immunology (Baltimore, Md. : 1950) Jun, 2008 | Pubmed ID: 18490732
Journal of cellular and molecular medicine Aug, 2008 | Pubmed ID: 18505469
Brain : a journal of neurology Jul, 2008 | Pubmed ID: 18567923
Glioma-like proliferation within tissues excised as tubers in patients with tuberous sclerosis complex.
Acta neuropathologica Jul, 2008 | Pubmed ID: 18581125
Neurosurgery Feb, 2008 | Pubmed ID: 18596454
Lancet neurology Aug, 2008 | Pubmed ID: 18635014
Neurosurgical focus Sep, 2008 | Pubmed ID: 18759614
Journal of the neurological sciences Nov, 2008 | Pubmed ID: 18804221
Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2008 | Pubmed ID: 18941193
Nature reviews. Drug discovery Nov, 2008 | Pubmed ID: 18974749
Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale.
Archives of neurology Nov, 2008 | Pubmed ID: 19001162
Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2008 | Pubmed ID: 19017937
Proceedings of the National Academy of Sciences of the United States of America Dec, 2008 | Pubmed ID: 19028871
Journal of the American Statistical Association Dec, 2007 | Pubmed ID: 19081806
Journal of autoimmunity Mar, 2009 | Pubmed ID: 19181483
Deep gray matter involvement on brain MRI scans is associated with clinical progression in multiple sclerosis.
Journal of neuroimaging : official journal of the American Society of Neuroimaging Jan, 2009 | Pubmed ID: 19192042
Rate of brain atrophy in benign vs early multiple sclerosis.
Archives of neurology Feb, 2009 | Pubmed ID: 19204160
The role of the CD58 locus in multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2009 | Pubmed ID: 19237575
NeuroImage Jul, 2009 | Pubmed ID: 19281850
European journal of immunology Mar, 2009 | Pubmed ID: 19283716
The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease?
Annals of neurology Mar, 2009 | Pubmed ID: 19334069
Pediatric neurosurgery , 2009 | Pubmed ID: 19440004
International immunology Jul, 2009 | Pubmed ID: 19515797
Nature genetics Jul, 2009 | Pubmed ID: 19525953
Journal of neurosurgery. Pediatrics Jul, 2009 | Pubmed ID: 19569916
Journal of immunology (Baltimore, Md. : 1950) Aug, 2009 | Pubmed ID: 19625647
Journal of immunology (Baltimore, Md. : 1950) Sep, 2009 | Pubmed ID: 19675171
Nature immunology Sep, 2009 | Pubmed ID: 19684606
Journal of clinical immunology Jan, 2010 | Pubmed ID: 19756989
Epilepsy & behavior : E&B Nov, 2009 | Pubmed ID: 19767244
European journal of immunology Dec, 2009 | Pubmed ID: 19768696
Brain MRI lesion load at 1.5T and 3T versus clinical status in multiple sclerosis.
Journal of neuroimaging : official journal of the American Society of Neuroimaging Apr, 2011 | Pubmed ID: 19888926
Journal of neuroimmunology Apr, 2010 | Pubmed ID: 19931190
The association between cognitive impairment and quality of life in patients with early multiple sclerosis.
Journal of the neurological sciences Mar, 2010 | Pubmed ID: 19944429
PloS one , 2010 | Pubmed ID: 20221429
Journal of immunology (Baltimore, Md. : 1950) May, 2010 | Pubmed ID: 20368276
T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America May, 2010 | Pubmed ID: 20368430
Proceedings of the National Academy of Sciences of the United States of America May, 2010 | Pubmed ID: 20445103
Epilepsia Jul, 2010 | Pubmed ID: 20491878
Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2010 | Pubmed ID: 20534530
Journal of neuroimmunology Oct, 2010 | Pubmed ID: 20580440
Journal of neurosurgery. Pediatrics Aug, 2010 | Pubmed ID: 20672932
Nature immunology Sep, 2010 | Pubmed ID: 20676092
Nature immunology Sep, 2010 | Pubmed ID: 20676095
Mucosal anti-CD3 monoclonal antibody attenuates collagen-induced arthritis that is associated with induction of LAP+ regulatory T cells and is enhanced by administration of an emulsome-based Th2-skewing adjuvant.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2010 | Pubmed ID: 20720210
Journal of immunology (Baltimore, Md. : 1950) Sep, 2010 | Pubmed ID: 20720212
Journal of immunological methods Oct, 2010 | Pubmed ID: 20837018
Archives of neurology Sep, 2010 | Pubmed ID: 20837847
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery Mar, 2011 | Pubmed ID: 20853002
Ocular immunology and inflammation Dec, 2010 | Pubmed ID: 20887202
Annals of neurology Dec, 2010 | Pubmed ID: 21061396
Proceedings of the National Academy of Sciences of the United States of America Nov, 2010 | Pubmed ID: 21068375
Neurosurgery Jan, 2011 | Pubmed ID: 21099705
Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments.
Journal of neuroimmunology Apr, 2011 | Pubmed ID: 21115201
PloS one , 2010 | Pubmed ID: 21124798
Nature medicine Jan, 2011 | Pubmed ID: 21131957
A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis.
PloS one , 2010 | Pubmed ID: 21152065
Epilepsy & behavior : E&B Mar, 2011 | Pubmed ID: 21288778
Neurobiology of aging Feb, 2012 | Pubmed ID: 21371785
Patient reported outcomes in benign multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) Jul, 2011 | Pubmed ID: 21372114
Journal of neurology, neurosurgery, and psychiatry Oct, 2011 | Pubmed ID: 21429902
The relationship between normal cerebral perfusion patterns and white matter lesion distribution in 1,249 patients with multiple sclerosis.
Journal of neuroimaging : official journal of the American Society of Neuroimaging Apr, 2012 | Pubmed ID: 21447022
Journal of neurosurgery. Pediatrics Apr, 2011 | Pubmed ID: 21456917
Oral tolerance.
Immunological reviews May, 2011 | Pubmed ID: 21488901
PloS one , 2011 | Pubmed ID: 21494571
Journal of neurosurgery. Pediatrics Jun, 2011 | Pubmed ID: 21631205
Epilepsia Jun, 2011 | Pubmed ID: 21671922
Immunobiology Oct, 2011 | Pubmed ID: 21676485
Cognitive deterioration in patients with early multiple sclerosis: a 5-year study.
Journal of neurology, neurosurgery, and psychiatry Jan, 2012 | Pubmed ID: 21746743
Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring.
Lancet neurology Aug, 2011 | Pubmed ID: 21777829
Journal of immunology (Baltimore, Md. : 1950) Sep, 2011 | Pubmed ID: 21788439
In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling.
PloS one , 2011 | Pubmed ID: 21886804
Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in mice.
Gastroenterology Dec, 2011 | Pubmed ID: 21925467
European journal of immunology Jan, 2012 | Pubmed ID: 22002875
PloS one , 2011 | Pubmed ID: 22039443
Induction of immunological tolerance by oral anti-CD3.
Clinical & developmental immunology , 2012 | Pubmed ID: 22162715
Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal study.
Journal of the neurological sciences Apr, 2012 | Pubmed ID: 22209496
Epilepsy control following intracranial monitoring without resection in young children.
Epilepsia Feb, 2012 | Pubmed ID: 22242686
IL-27 induction of IL-21 from human CD8+ T cells induces granzyme B in an autocrine manner.
Immunology and cell biology Mar, 2012 | Pubmed ID: 22430249
Journal of neurosurgery. Pediatrics Apr, 2012 | Pubmed ID: 22462706
Journal of neurosurgery. Pediatrics Apr, 2012 | Pubmed ID: 22462708
Journal of neuroimmunology Jul, 2012 | Pubmed ID: 22579051
Glia May, 2012 | Pubmed ID: 22653784
Immunological reviews Jul, 2012 | Pubmed ID: 22725961
Proceedings of the National Academy of Sciences of the United States of America Jul, 2012 | Pubmed ID: 22745170
PloS one , 2012 | Pubmed ID: 22768094
The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction.
Immunity Nov, 2012 | Pubmed ID: 23123061
IFN-γ limits Th9-mediated autoimmune inflammation through dendritic cell modulation of IL-27.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2012 | Pubmed ID: 23125412
Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus.
Neurology Nov, 2013 | Pubmed ID: 24174586
Brain MRI of nasal MOG therapeutic effect in relapsing-progressive EAE.
Experimental neurology May, 2014 | Pubmed ID: 24552689
In vivo anti-LAP mAb enhances IL-17/IFN-γ responses and abrogates anti-CD3-induced oral tolerance.
International immunology Feb, 2015 | Pubmed ID: 25194146
MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis.
The Journal of clinical investigation Mar, 2015 | Pubmed ID: 25642768
MicroRNA-21, T helper lineage and autoimmunity.
Oncotarget , 2015 | Pubmed ID: 25991670
Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation.
Journal of neuroinflammation Dec, 2015 | Pubmed ID: 26714756
The Host Shapes the Gut Microbiota via Fecal MicroRNA.
Cell host & microbe Jan, 2016 | Pubmed ID: 26764595
Immunology. How does the immune system tolerate food?
Science (New York, N.Y.) Feb, 2016 | Pubmed ID: 26912876
Power estimation for non-standardized multisite studies.
NeuroImage 07, 2016 | Pubmed ID: 27039700
Dysregulation of regulatory CD56(bright) NK cells/T cells interactions in multiple sclerosis.
Journal of autoimmunity 08, 2016 | Pubmed ID: 27157273
IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation.
Brain : a journal of neurology Jul, 2016 | Pubmed ID: 27246324
Mucosal administration of CD3-specific monoclonal antibody inhibits diabetes in NOD mice and in a preclinical mouse model transgenic for the CD3 epsilon chain.
Journal of autoimmunity 01, 2017 | Pubmed ID: 27745778
Survivin controls biogenesis of microRNA in smokers: A link to pathogenesis of rheumatoid arthritis.
Biochimica et biophysica acta. Molecular basis of disease 03, 2017 | Pubmed ID: 27915033
IL-6 Inhibits Upregulation of Membrane-Bound TGF-β 1 on CD4+ T Cells and Blocking IL-6 Enhances Oral Tolerance.
Journal of immunology (Baltimore, Md. : 1950) 02, 2017 | Pubmed ID: 28039301
Targeting latency-associated peptide promotes antitumor immunity.
Science immunology May, 2017 | Pubmed ID: 28763794
History and mechanisms of oral tolerance.
Seminars in immunology 04, 2017 | Pubmed ID: 28774470
A two-year study using cerebral gray matter volume to assess the response to fingolimod therapy in multiple sclerosis.
Journal of the neurological sciences Dec, 2017 | Pubmed ID: 29146095
Transcriptional signature of human pro-inflammatory T17 cells identifies reduced IL10 gene expression in multiple sclerosis.
Nature communications 11, 2017 | Pubmed ID: 29150604
Microbiota Signaling Pathways that Influence Neurologic Disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 01, 2018 | Pubmed ID: 29340928
Multiple Sclerosis: Mechanisms and Immunotherapy.
Neuron 02, 2018 | Pubmed ID: 29470968
Microglial signatures and their role in health and disease.
Nature reviews. Neuroscience Oct, 2018 | Pubmed ID: 30206328
Acute microglia ablation induces neurodegeneration in the somatosensory system.
Nature communications 11, 2018 | Pubmed ID: 30385785
The sex-specific interaction of the microbiome in neurodegenerative diseases.
Brain research 12, 2019 | Pubmed ID: 31419428
Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity.
Cell reports 09, 2019 | Pubmed ID: 31553906
Oral Administration of miR-30d from Feces of MS Patients Suppresses MS-like Symptoms in Mice by Expanding Akkermansia muciniphila.
Cell host & microbe 12, 2019 | Pubmed ID: 31784260
A One-Two Punch in the Gut May Trigger Multiple Sclerosis.
Immunity Oct, 2020 | Pubmed ID: 33053328
Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
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