Zena Werb

Shedding light on sheddases: role in growth and development.

Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2.

Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency.

Developmental biology: vasculogenesis is a wreck without RECK.

New functions for the matrix metalloproteinases in cancer progression.

Metalloproteases and adipogenesis: a weighty subject.

Stromal effects on mammary gland development and breast cancer.

Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand.

Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment.

Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases.

The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors.

Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events.

beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium.

Matrix metalloproteinase-9 contributes to choroidal neovascularization.

Matrix metalloproteinase-9-dependent exposure of a cryptic migratory control site in collagen is required before retinal angiogenesis.

Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans.

New functional roles for non-collagenous domains of basement membrane collagens.

Inflammation and cancer.

Tube or not tube: remodeling epithelial tissues by branching morphogenesis.

Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases.

New insights into saccular development and vascular formation in lung allografts under the renal capsule.

Epithelial morphogenesis: Netrin comes to a sticky and terminal end.

How proteases regulate bone morphogenesis.

Role of collagen type II and perlecan in skeletal development.

Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin.

Altered fracture repair in the absence of MMP9.

A functional overlap of plasminogen and MMPs regulates vascularization during placental development.

Macrophages contribute to the maintenance of stable regenerating neurites following peripheral nerve injury.

Differential temporal expression of matrix metalloproteinases after spinal cord injury: relationship to revascularization and wound healing.

Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells.

Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis.

Role of c-kit/Kit ligand signaling in regulating vasculogenesis.

Blood-spinal cord barrier after spinal cord injury: relation to revascularization and wound healing.

MMP-2 and MMP-9 synergize in promoting choroidal neovascularization.

Ets2-dependent stromal regulation of mouse mammary tumors.

A bit of give and take: the relationship between the extracellular matrix and the developing chondrocyte.

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.

Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes.

Zena Werb [interview by Fiona M Watt].

Stromal matrix metalloproteinase-9 regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment.

Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines.

Matrix remodeling during endochondral ossification.

Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues.

Regulation of matrix biology by matrix metalloproteinases.

Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment.

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice.

Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes.

Tissue inhibitor of metalloproteinase 1 regulates resistance to infection.

Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.

Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation.

Synergy between a plasminogen cascade and MMP-9 in autoimmune disease.

Coevolution of cancer and stromal cellular responses.

Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice.

Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability.

A role for niches in hematopoietic cell development.

Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin.

PDGFRbeta+ perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival.

Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization.

Discoidin domain receptor 2 mediates tumor cell cycle arrest induced by fibrillar collagen.

Mfge8 is critical for mammary gland remodeling during involution.

Mice deficient in Ext2 lack heparan sulfate and develop exostoses.

Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer.

Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice.

HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1.

Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease.

Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes.

Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.

Hormonal and local control of mammary branching morphogenesis.

Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury.

Candidate regulators of mammary branching morphogenesis identified by genome-wide transcript analysis.

Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammation.

Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2.

Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression.

Comparative mechanisms of branching morphogenesis in diverse systems.

GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland.

Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.

Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted.

Roles of the innate immune system in mammary gland remodeling during involution.

Matrix metalloproteinases and the regulation of tissue remodelling.

Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis.

The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10.

Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8).

Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development.

The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium.

G'rab'bing the microenvironment for invasion.

Role of matrix metalloproteinase 13 in both endochondral and intramembranous ossification during skeletal regeneration.

Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma.

CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression.

GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model.

A model of intussusceptive angiogenesis.

HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion.

GATA-3 and the regulation of the mammary luminal cell fate.

The apical ectodermal ridge is a timer for generating distal limb progenitors.

Location, location, location: the cancer stem cell niche.

The plasminogen fibrinolytic pathway is required for hematopoietic regeneration.

Lentiviral transduction of mammary stem cells for analysis of gene function during development and cancer.

Cell-polarity dynamics controls the mechanism of lumen formation in epithelial morphogenesis.

Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis.

Lifeact: a versatile marker to visualize F-actin.

Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis.

Matrix metalloproteinase 13 is induced in fibroblasts in polyomavirus middle T antigen-driven mammary carcinoma without influencing tumor progression.

Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy.

Patterning mechanisms of branched organs.

Matrix metalloproteinase-9 facilitates glial scar formation in the injured spinal cord.

Active plasma kallikrein localizes to mast cells and regulates epithelial cell apoptosis, adipocyte differentiation, and stromal remodeling during mammary gland involution.

MMP9 and SCF protect from apoptosis in acute kidney injury.

Netting neutrophils in autoimmune small-vessel vasculitis.

GATA3 in development and cancer differentiation: cells GATA have it!

Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis.

Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages.

MMP13 as a stromal mediator in controlling persistent angiogenesis in skin carcinoma.

Intravital imaging of stromal cell dynamics in tumors.

Mapping mammary gland architecture using multi-scale in situ analysis.

Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.

Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation.

Matrix metalloproteinases contribute distinct roles in neuroendocrine prostate carcinogenesis, metastasis, and angiogenesis progression.

Stromal regulation of vessel stability by MMP14 and TGFbeta.

Matrix metalloproteinases: regulators of the tumor microenvironment.

Matrix metalloproteinases and neurotrauma: evolving roles in injury and reparative processes.

Tumors as organs: complex tissues that interface with the entire organism.

The extracellular matrix and disease: An interview with Zena Werb. Interviewed by Kristin H. Kain.

The joy of a career in cell biology.

Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression.

Mammary gland reprogramming: metalloproteinases couple form with function.

Impaired remodeling phase of fracture repair in the absence of matrix metalloproteinase-2.

Preparation of mice for long-term intravital imaging of the mammary gland.

Monitoring of vital signs for long-term survival of mice under anesthesia.

Dynamic, long-term in vivo imaging of tumor-stroma interactions in mouse models of breast cancer using spinning-disk confocal microscopy.

Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization.

A whole-organism screen identifies new regulators of fat storage.

Measuring matrix metalloproteinase activity in macrophages and polymorphonuclear leukocytes.

Dual protective mechanisms of matrix metalloproteinases 2 and 9 in immune defense against Streptococcus pneumoniae.

Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid.

Extracellular matrix degradation and remodeling in development and disease.

Matrix metalloproteinase-9 and stromal cell-derived factor-1 act synergistically to support migration of blood-borne monocytes into the injured spinal cord.

Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma.

Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity.

Mammary collective cell migration involves transient loss of epithelial features and individual cell migration within the epithelium.

The extracellular matrix: a dynamic niche in cancer progression.

Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells.

Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance.

Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury.

The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression.

ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium.

MMP9 regulates the cellular response to inflammation after skeletal injury.

MicroRNAs play a big role in regulating ovarian cancer-associated fibroblasts and the tumor microenvironment.

Lgr5-expressing cells are sufficient and necessary for postnatal mammary gland organogenesis.

GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.

Molecular determinants of lung development.

Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction.

Protective effects of matrix metalloproteinase-12 following corneal injury.

A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathway.

Roadblocks to translational advances on metastasis research.

Cancer. Circulating tumor cells.

microRNA-mediated regulation of the tumor microenvironment.

In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding.

Collective invasion in breast cancer requires a conserved basal epithelial program.

Efficacy of a metalloproteinase inhibitor in spinal cord injured dogs.

A Multilevel Model of Postmenopausal Breast Cancer Incidence.