Jian-Fu Chen

The African Zika virus MR-766 is more virulent and causes more severe brain damage than current Asian lineage and dengue virus.

Brain cytoplasmic RNA 1 suppresses smooth muscle differentiation and vascular development in mice.

Mesenchyme Homeobox 1 mediates transforming growth factor-β (TGF-β)-induced smooth muscle cell differentiation from mouse mesenchymal progenitors.

C9orf72 deficiency promotes motor deficits of a C9ALS/FTD mouse model in a dose-dependent manner.

Lin28-mediated temporal promotion of protein synthesis is crucial for neural progenitor cell maintenance and brain development in mice.

Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors.

Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis.

Ribosome biogenesis controls cranial suture MSC fate via the complement pathway in mouse and human iPSC models.

Brain methylome remodeling selectively regulates neuronal activity genes linking to emotional behaviors in mice exposed to maternal immune activation.