R. Holland Cheng

Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity.

Congo red and thioflavin-T analogs detect Abeta oligomers.

Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents.

Well-defined, size-tunable, multifunctional micelles for efficient paclitaxel delivery for cancer treatment.

Structure of the arginine methyltransferase PRMT5-MEP50 reveals a mechanism for substrate specificity.

Controlling the diameter, monodispersity, and solubility of ApoA1 nanolipoprotein particles using telodendrimer chemistry.

Compensation of missing wedge effects with sequential statistical reconstruction in electron tomography.

Permeability changes of integrin-containing multivesicular structures triggered by picornavirus entry.

Developmentally Regulated Post-translational Modification of Nucleoplasmin Controls Histone Sequestration and Deposition.

A Bayesian approach for suppression of limited angular sampling artifacts in single particle 3D reconstruction.

Chemically activatable viral capsid functionalized for cancer targeting.

Cell-free production of a functional oligomeric form of a major outer-membrane protein (MOMP) for vaccine development.

Structural characterization of site-modified nanocapsid with monodispersed gold clusters.

Nanodelivery of a functional membrane receptor to manipulate cellular phenotype.