finite-element-modelling-of-a-cellular-electric-microenvironment

Finite Element Modelling of a Cellular Electric Microenvironment

Clinical studies show electrical stimulation (ES) to be a potential therapy for the healing and regeneration of various tissues. Understanding the ...

The University of Manchester

Being able to predict bone fracture or implant stability needs a proper constitutive model of trabecular bone at the macroscale in multiaxial, non-monotonic loading modes. Its macroscopic damage behaviour has been investigated experimentally in the past, mostly with the restriction of uniaxial cyclic loading experiments for different samples, which does not allow for the investigation of several load cases in the same sample as damage in one direction may affect the behaviour in other directions. Homogenised finite element models of whole bones have the potential to assess complicated scenarios and thus improve clinical predictions. The aim of this study is to use a homogenisation-based multiscale procedure to upscale the damage behaviour of bone from an assumed solid phase constitutive law and investigate its multiaxial behaviour for the first time. Twelve cubic specimens were each submitted to nine proportional strain histories by using a parallel code developed in-house. Evolution of post-elastic properties for trabecular bone was assessed for a small range of macroscopic plastic strains in these nine load cases. Damage evolution was found to be non-isotropic, and both damage and hardening were found to depend on the loading mode (tensile, compression or shear); both were characterised by linear laws with relatively high coefficients of determination. It is expected that the knowledge of the macroscopic behaviour of trabecular bone gained in this study will help in creating more precise continuum FE models of whole bones that improve clinical predictions.

Effect of including damage at the tissue level in the nonlinear homogenisation of trabecular bone.

The purpose of this paper is to provide a high level, holistic overview of the work being undertaken in the wind energy industry. It summarises the main techniques used to simulate both aerodynamic and structural issues associated with wind turbines and farms. The motivation behind this paper is to provide new researchers with an outlook of the modelling and simulation landscape, whilst highlighting the trends and direction research is taking. Each section summarises an individual area of simulation and modelling, covering the important historical research findings and a comprehensive analysis of recent work. This segregated approach emphasises the key components of wind energy. Topics range in geometric scales and detail, ranging from atmospheric boundary layer modelling, to fatigue and fracture in the turbine blades. More recent studies have begun to combine a range of scales and physics to better approximate real systems and provide higher fidelity and accurate analyses to manufacturers and companies. This paper shows a clear trend towards coupling both scales and physics into singular models utilising high performance computing system.

Lee Margetts

Department of Mechanical,
Aerospace and Civil Engineering,
Faculty of Science and Engineering,
Department of Mechanical, Aerospace and Civil Engineering, Faculty of Science and Engineering

The University of Manchester

Finite Element Modelling of a Cellular Electric Microenvironment

Lee Margetts

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Department of Mechanical,Aerospace and Civil Engineering,Faculty of Science and Engineering,Department of Mechanical, Aerospace and Civil Engineering, Faculty of Science and Engineering

The University of Manchester

Finite Element Modelling of a Cellular Electric Microenvironment

Department of Mechanical,
Aerospace and Civil Engineering,
Faculty of Science and Engineering,
Department of Mechanical, Aerospace and Civil Engineering, Faculty of Science and Engineering