Angela C. Brown

Department of Chemical and Biomolecular Engineering

Lehigh University

BIOGRAPHY

Dr. Brown received her B.S. in Chemical Engineering from Penn State University. After receiving her Ph.D. in Chemical Engineering from Drexel University, she completed postdoctoral work at the University of Pennsylvania. Dr. Brown's research focuses on the development of novel therapeutics for the treatment of bacterial infections.

PUBLICATIONS

Disorder in cholesterol-binding functionality of CRAC peptides: a molecular dynamics study.

The journal of physical chemistry. B Nov, 2014 | Pubmed ID: 25347282

Inhibition of LtxA toxicity by blocking cholesterol binding with peptides.

Molecular oral microbiology Feb, 2016 | Pubmed ID: 26352738

Inhibition of Bacterial Toxin Activity by the Nuclear Stain, DRAQ5™.

The Journal of membrane biology 08, 2016 | Pubmed ID: 27039399

Use of a Cholesterol Recognition Amino Acid Consensus Peptide To Inhibit Binding of a Bacterial Toxin to Cholesterol.

Biochemistry 08, 2016 | Pubmed ID: 27504950

Association of Vibrio cholerae 569B outer membrane vesicles with host cells occurs in a GM1-independent manner.

Cellular microbiology 06, 2018 | Pubmed ID: 29377560

Receptor-Based Peptides for Inhibition of Leukotoxin Activity.

ACS infectious diseases 07, 2018 | Pubmed ID: 29742342

Generation of a recombinant Aggregatibacter actinomycetemcomitans RTX toxin in Escherichia coli.

Gene Sep, 2018 | Pubmed ID: 29879499

Leukotoxin Is Delivered to Host Cells in an LFA-1-Indepdendent Manner When Associated with Outer Membrane Vesicles.

Toxins 10, 2018 | Pubmed ID: 30322160

Catechin-mediated restructuring of a bacterial toxin inhibits activity.

Biochimica et biophysica acta. General subjects 01, 2019 | Pubmed ID: 30342156

Cytotoxic activity of Kingella kingae RtxA toxin depends on post-translational acylation of lysine residues and cholesterol binding.

Emerging microbes & infections Nov, 2018 | Pubmed ID: 30405113

Inhibition of bacterial toxin recognition of membrane components as an anti-virulence strategy.

Journal of biological engineering , 2019 | Pubmed ID: 30820243

Cholera Toxin Encapsulated within Several O1 Serotype Inaba Outer Membrane Vesicles Lacks a Functional B-Subunit.

Toxins 04, 2019 | Pubmed ID: 30959895

Epigallocatechin gallate inhibits leukotoxin release by Aggregatibacter actinomycetemcomitans by promoting association with the bacterial membrane.

Molecular oral microbiology 01, 2020 | Pubmed ID: 31816197

Aggregatibacter actinomycetemcomitans leukotoxin: From mechanism to targeted anti-toxin therapeutics.

Molecular oral microbiology 06, 2020 | Pubmed ID: 32061022

INSTITUTIONS

Lehigh University

JOVE ARTICLES

Size Exclusion Chromatography to Analyze Bacterial Outer Membrane Vesicle Heterogeneity

Shannon M. Collins¹,

Justin B. Nice¹,

En Hyung Chang¹,

Angela C. Brown¹

¹Department of Chemical and Biomolecular Engineering, Lehigh University

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