Ellen Wiedtke

Cluster of Excellence CellNetworks,
Department of Infectious Diseases,
Virology,
Cluster of Excellence CellNetworks, Department of Infectious Diseases, Virology

Heidelberg University

BIOGRAPHY

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PUBLICATIONS

Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development.

Proceedings of the National Academy of Sciences of the United States of America Feb, 2017 | Pubmed ID: 28137845

Relevance of Assembly-Activating Protein for Adeno-associated Virus Vector Production and Capsid Protein Stability in Mammalian and Insect Cells.

Journal of virology 10, 2017 | Pubmed ID: 28768875

Impact of the Assembly-Activating Protein on Molecular Evolution of Synthetic Adeno-Associated Virus Capsids.

Human gene therapy 01, 2019 | Pubmed ID: 29978729

AAVvector-mediated in vivo reprogramming into pluripotency.

Nature communications 07, 2018 | Pubmed ID: 29985406

A Robust and All-Inclusive Pipeline for Shuffling of Adeno-Associated Viruses.

ACS synthetic biology 01, 2019 | Pubmed ID: 30513195

Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening.

Molecular therapy : the journal of the American Society of Gene Therapy 04, 2020 | Pubmed ID: 32105604

The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner.

Cell reports 08, 2021 | Pubmed ID: 34407407

Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors.

Molecular therapy : the journal of the American Society of Gene Therapy 05, 2022 | Pubmed ID: 35038579

Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders.

Science advances 09, 2022 | Pubmed ID: 36129972

INSTITUTIONS

Heidelberg University

University of Heidelberg

JOVE ARTICLES

Engineering and Evolution of Synthetic Adeno-Associated Virus (AAV) Gene Therapy Vectors via DNA Family Shuffling

Eike Kienle^*,1,

Elena Senís^*,1,

Kathleen Börner²,

Dominik Niopek¹,

Ellen Wiedtke¹,

Stefanie Grosse¹,

Dirk Grimm¹

¹Cluster of Excellence CellNetworks, Department of Infectious Diseases, Virology, Heidelberg University,

²Department of Infectious Diseases, Virology, Heidelberg University

Immunology and Infection

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus (AAV) Capsid Variants

Kleopatra Rapti^1,2,

Olena Maiakovska^1,2,

Jonas Becker^1,2,

Joanna Szumska^1,2,

Margarita Zayas^1,2,

Felix Bubeck^1,2,

Jixin Liu^1,2,

Emma Gerstmann^1,2,

Chiara Krämer^1,2,

Ellen Wiedtke^1,2,

Dirk Grimm^1,2,3,4,5

¹Department of Infectious Diseases/Virology, Section Viral Vector Technologies, Medical Faculty, University of Heidelberg,

²BioQuant Center, BQ0030, University of Heidelberg,

³, Cluster of Excellence CellNetworks,

⁴, German Center for Infection Research (DZIF),

⁵, German Center for Cardiovascular Research (DZHK)

Bioengineering

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Ellen Wiedtke

Cluster of Excellence CellNetworks,Department of Infectious Diseases,Virology,Cluster of Excellence CellNetworks, Department of Infectious Diseases, Virology

Heidelberg University

Engineering and Evolution of Synthetic Adeno-Associated Virus (AAV) Gene Therapy Vectors via DNA Family Shuffling

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus (AAV) Capsid Variants

Cluster of Excellence CellNetworks,
Department of Infectious Diseases,
Virology,
Cluster of Excellence CellNetworks, Department of Infectious Diseases, Virology