Lirong Zhang

The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics,
Key Laboratory of Immune Microenvironment and Disease (Ministry of Education),
State Key Laboratory of Experimental Hematology,
Department of Biochemistry and Molecular Biology,
School of Basic Medical Sciences,
The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), State Key Laboratory of Experimental Hematology, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences

Tianjin Medical University

BIOGRAPHY

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PUBLICATIONS

Targeting Super-Enhancer-Driven Oncogenic Transcription by CDK7 Inhibition in Anaplastic Thyroid Carcinoma.

Thyroid : official journal of the American Thyroid Association Jun, 2019 | Pubmed ID: 30924726

Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease.

Science advances Jun, 2019 | Pubmed ID: 31183407

Targeting CDK12-mediated transcription regulation in anaplastic thyroid carcinoma.

Biochemical and biophysical research communications Dec, 2019 | Pubmed ID: 31615655

HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription.

Nucleic acids research Jul, 2020 | Pubmed ID: 32459350

Super-enhancer-driven metabolic reprogramming promotes cystogenesis in autosomal dominant polycystic kidney disease.

Nature metabolism Aug, 2020 | Pubmed ID: 32694829

Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease.

Science translational medicine Jul, 2020 | Pubmed ID: 32727915

PKD2 deficiency suppresses amino acid biosynthesis in ADPKD by impairing the PERK-TBL2-eIF2ɑ-ATF4 pathway.

Biochemical and biophysical research communications Jul, 2021 | Pubmed ID: 34015761

cAMP-Induced Nuclear Condensation of CRTC2 Promotes Transcription Elongation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Apr, 2022 | Pubmed ID: 35037420

Epigenomic reprogramming via HRP2-MINA dictates response to proteasome inhibitors in multiple myeloma with t(4;14) translocation.

The Journal of clinical investigation Feb, 2022 | Pubmed ID: 35166240

White tea alleviates non-alcoholic fatty liver disease by regulating energy expenditure and lipid metabolism.

Gene Jul, 2022 | Pubmed ID: 35569768

Nuclear Condensation of CDYL Links Histone Crotonylation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease.

Journal of the American Society of Nephrology : JASN Sep, 2022 | Pubmed ID: 35918147

Chromatin accessibility dynamics dictate renal tubular epithelial cell response to injury.

Nature communications Nov, 2022 | Pubmed ID: 36443310

Multi-omics profiling of cholangiocytes reveals sex-specific chromatin state dynamics during hepatic cystogenesis in polycystic liver disease.

Journal of hepatology Apr, 2023 | Pubmed ID: 36681161

Non-invasive diagnosis of acute kidney injury using Mn-doped carbon dots-based magnetic resonance imaging.

Biomaterials science Jun, 2023 | Pubmed ID: 37063063

Phase Separation in Kidney Diseases: Autosomal Dominant Polycystic Kidney Disease and Beyond.

Kidney diseases (Basel, Switzerland) Aug, 2023 | Pubmed ID: 37899998

Epigenomic, cistromic, and transcriptomic profiling of primary kidney tubular cells.

Journal of biological methods , 2024 | Pubmed ID: 39323486

Melanin-like nanoparticles slow cyst growth in ADPKD by dual inhibition of oxidative stress and CREB.

EMBO molecular medicine Jan, 2025 | Pubmed ID: 39567834

Enhancer Profiling Reveals a Protective Role of RXRα Against Calcium Oxalate-Induced Crystal Deposition and Kidney Injury.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) Mar, 2025 | Pubmed ID: 40091688

Condensation of cellular prion protein promotes renal fibrosis through the TBK1-IRF3 signaling axis.

Science translational medicine Apr, 2025 | Pubmed ID: 40238918

INSTITUTIONS

Tianjin Medical University

JOVE ARTICLES

Isolation and Culture of Primary Cholangiocytes from Mice with Polycystic Liver Disease Using a Two-step Digestion Method

Rongjie Ji¹,

Bo Qing²,

Jiayuan Chen²,

Zhigang Zhao¹,

Lirong Zhang²

¹Department of Medical Oncology, Tianjin First Central Hospital, School of Medicine, Nankai University,

²The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), State Key Laboratory of Experimental Hematology, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University

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