Matthew W. Kelley

Laboratory of Cochlear Development, NIDCD, NIH

Affiliated withNIDCD, NIH National Institute On Deafness And Other Communication Disorders

Research Area

Developmental BiologyNeuroscience

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title	2015
Publication title	2018

Other Publications

Article	Year
Knock-in mouse model for resistance to thyroid hormone (RTH): an RTH mutation in the thyroid hormone receptor beta gene disrupts cochlear morphogenesis. Journal of the Association for Research in Otolaryngology : JARO\| PubMed ID: 12382103	2002
Fibroblast growth factor signaling regulates pillar cell development in the organ of corti. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12417662	2002
Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea. Development (Cambridge, England)\| PubMed ID: 12702652	2003
Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature\| PubMed ID: 12724779	2003
Determination and commitment of mechanosensory hair cells. TheScientificWorldJournal\| PubMed ID: 12805965	2002
Exposing the roots of hair cell regeneration in the ear. Nature medicine\| PubMed ID: 14520370	2003
Planar and vertical signals control cellular differentiation and patterning in the mammalian cochlea. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 14561877	2003
Analysis of nuclear receptor function in the mouse auditory system. Methods in enzymology\| PubMed ID: 14631859	2003
Cell adhesion molecules during inner ear and hair cell development, including notch and its ligands. Current topics in developmental biology\| PubMed ID: 14674486	2003
Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 14993610	2004
Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell\| PubMed ID: 15035989	2004
Cellular growth and rearrangement during the development of the mammalian organ of Corti. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 15042704	2004
Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene. Human molecular genetics\| PubMed ID: 15254021	2004
From placode to polarization: new tunes in inner ear development. Development (Cambridge, England)\| PubMed ID: 15319325	2004
Math1 regulates development of the sensory epithelium in the mammalian cochlea. Nature neuroscience\| PubMed ID: 15543141	2004
Planar cell polarity and a potential role for a Wnt morphogen gradient in stereociliary bundle orientation in the mammalian inner ear. Journal of neurobiology\| PubMed ID: 16041762	2005
Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16407553	2006
Hair cell development: commitment through differentiation. Brain research\| PubMed ID: 16626654	2006
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16687519	2006
Noncanonical Wnt signaling and neural polarity. Annual review of neuroscience\| PubMed ID: 16776590	2006
Regulation of cell fate in the sensory epithelia of the inner ear. Nature reviews. Neuroscience\| PubMed ID: 17053809	2006
Myosin VI and VIIa distribution among inner ear epithelia in diverse fishes. Hearing research\| PubMed ID: 17204383	2007
Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system. The European journal of neuroscience\| PubMed ID: 17331196	2007
Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 17557302	2007
Fgf8 induces pillar cell fate and regulates cellular patterning in the mammalian cochlea. Development (Cambridge, England)\| PubMed ID: 17634195	2007
Cellular commitment and differentiation in the organ of Corti. The International journal of developmental biology\| PubMed ID: 17891718	2007
Has hair cell loss MET its match? Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17925436	2007
Jxc1/Sobp, encoding a nuclear zinc finger protein, is critical for cochlear growth, cell fate, and patterning of the organ of corti. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18579736	2008
Leading Wnt down a PCP path: Cthrc1 acts as a coreceptor in the Wnt-PCP pathway. Developmental cell\| PubMed ID: 18606135	2008
Hedgehog signaling regulates sensory cell formation and auditory function in mice and humans. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18632939	2008
Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19011097	2008
Myosin II regulates extension, growth and patterning in the mammalian cochlear duct. Development (Cambridge, England)\| PubMed ID: 19439495	2009
Building the world's best hearing aid; regulation of cell fate in the cochlea. Current opinion in genetics & development\| PubMed ID: 19604683	2009
Regulation of cell fate and patterning in the developing mammalian cochlea. Current opinion in otolaryngology & head and neck surgery\| PubMed ID: 19623076	2009
Specification of cell fate in the mammalian cochlea. Birth defects research. Part C, Embryo today : reviews\| PubMed ID: 19750520	2009
Sox2 induces neuronal formation in the developing mammalian cochlea. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 20071536	2010
Transfection of mouse cochlear explants by electroporation. Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.]\| PubMed ID: 20373505	2010
CD44 is a marker for the outer pillar cells in the early postnatal mouse inner ear. Journal of the Association for Research in Otolaryngology : JARO\| PubMed ID: 20386946	2010
Development of tonotopy in the auditory periphery. Hearing research\| PubMed ID: 21276841	2011
Rbpj regulates development of prosensory cells in the mammalian inner ear. Developmental biology\| PubMed ID: 21420948	2011
Response to a letter to the editor. Hearing research\| PubMed ID: 21600274	2011
Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory function, protein localization, and axon targeting. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21646512	2011
Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 22159122	2011
Examining planar cell polarity in the mammalian cochlea. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 22218900	2012
Otic mesenchyme cells regulate spiral ganglion axon fasciculation through a Pou3f4/EphA4 signaling pathway. Neuron\| PubMed ID: 22243746	2012
Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis. The Journal of clinical investigation\| PubMed ID: 22446187	2012
Stem cell therapy for the inner ear: recent advances and future directions. Trends in amplification\| PubMed ID: 22514095	2012
Cytoskeletal changes in actin and microtubules underlie the developing surface mechanical properties of sensory and supporting cells in the mouse cochlea. Development (Cambridge, England)\| PubMed ID: 22573615	2012
Fgf signaling regulates development and transdifferentiation of hair cells and supporting cells in the basilar papilla. Hearing research\| PubMed ID: 22575790	2012
Molecular mechanisms of inner ear development. Cold Spring Harbor perspectives in biology\| PubMed ID: 22855724	2012
Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear. Development (Cambridge, England)\| PubMed ID: 22991442	2012
A dual function for canonical Wnt/β-catenin signaling in the developing mammalian cochlea. Development (Cambridge, England)\| PubMed ID: 23132246	2012
Planar cell polarity in the inner ear. Current topics in developmental biology\| PubMed ID: 23140627	2012
Fibroblast growth factor receptor 3 regulates microtubule formation and cell surface mechanical properties in the developing organ of Corti. Bioarchitecture\| PubMed ID: 23267415	2012
The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea. Developmental biology\| PubMed ID: 23318633	2013
Cilia, Wnt signaling, and the cytoskeleton. Cilia\| PubMed ID: 23351924	2012
Thyroid hormone increases fibroblast growth factor receptor expression and disrupts cell mechanics in the developing organ of corti. BMC developmental biology\| PubMed ID: 23394545	2013
Making sense with thyroid hormone--the role of T(3) in auditory development. Nature reviews. Endocrinology\| PubMed ID: 23529044	2013
Making connections in the inner ear: recent insights into the development of spiral ganglion neurons and their connectivity with sensory hair cells. Seminars in cell & developmental biology\| PubMed ID: 23660234	2013
Expression of insulin-like growth factor binding proteins during mouse cochlear development. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 23813480	2013
Expression and function of scleraxis in the developing auditory system. PloS one\| PubMed ID: 24058692	2013
Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS biology\| PubMed ID: 24302887	2013
A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear. Nature communications\| PubMed ID: 24845721	2014
Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea. Nature communications\| PubMed ID: 24845860	2014
Pou3f4-mediated regulation of ephrin-b2 controls temporal bone development in the mouse. PloS one\| PubMed ID: 25299585	2014