Friedrich Haag

Complex regulation of the human gene for the Z-DNA binding protein DLM-1.

Mono-ADP-ribosyltransferases in human monocytes: regulation by lipopolysaccharide.

The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse.

Expression, purification, crystallization and preliminary X-ray analysis of rat ecto-ADP-ribosyltransferase 2 (ART2.2).

Effects of interleukin-2 plus highly active antiretroviral therapy on HIV-1 replication and proviral DNA (COSMIC trial).

Independent integration of rodent identifier (ID) elements into orthologous sites of some RT6 alleles of Rattus norvegicus and Rattus rattus.

Structure of the ecto-ADP-ribosyl transferase ART2.2 from rat.

Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice.

Cutting edge: a natural P451L mutation in the cytoplasmic domain impairs the function of the mouse P2X7 receptor.

Flow cytometric and immunoblot assays for cell surface ADP-ribosylation using a monoclonal antibody specific for ethenoadenosine.

Effects of mitoxantrone on multiple sclerosis patients' lymphocyte subpopulations and production of immunoglobulin, TNF-alpha and IL-10.

NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor.

Triggering of T-cell apoptosis by toxin-related ecto-ADP-ribosyltransferase ART2.

T-cell survival regulator LKLF is not involved in inappropriate apoptosis of diabetes-prone BBDP rat T cells.

Ecto-ADP-ribosyltransferases (ARTs): emerging actors in cell communication and signaling.

T cells of different developmental stages differ in sensitivity to apoptosis induced by extracellular NAD.

Mono-allelic expression of the IGF-I receptor does not affect IGF responses in human fibroblasts.

Activity and specificity of toxin-related mouse T cell ecto-ADP-ribosyltransferase ART2.2 depends on its association with lipid rafts.

A PKR-like eukaryotic initiation factor 2alpha kinase from zebrafish contains Z-DNA binding domains instead of dsRNA binding domains.

CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins.

Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate.

Probing the expression and function of the P2X7 purinoceptor with antibodies raised by genetic immunization.

A panel of monoclonal antibodies recognizing GPI-anchored ADP-ribosyltransferase ART4, the carrier of the Dombrock blood group antigens.

Characterization of multiple alleles of the T-cell differentiation marker ART2 (RT6) in inbred and wild rats.

In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs).

Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation.

Up-regulation of the T cell quiescence factor KLF2 in a leukaemic T-cell line after expression of the inositol 5'-phosphatase SHIP-1.

Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion.

ADP-ribosylation of membrane proteins: unveiling the secrets of a crucial regulatory mechanism in mammalian cells.

The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation.

Chemokine receptor CXCR3 mediates T cell recruitment and tissue injury in nephrotoxic nephritis in mice.

Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo.

NAD+ released during inflammation participates in T cell homeostasis by inducing ART2-mediated death of naive T cells in vivo.

Autophagic cell death induced by TrkA receptor activation in human glioblastoma cells.

CD83 modulates B cell function in vitro: increased IL-10 and reduced Ig secretion by CD83Tg B cells.

ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site.

Lipopolysaccharide, IFN-gamma, and IFN-beta induce expression of the thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in murine macrophages.

Extracellular NAD and ATP: Partners in immune cell modulation.

Monitoring the expression of purinoceptors and nucleotide-metabolizing ecto-enzymes with antibodies directed against proteins in native conformation.

The cellular localization of autotaxin impacts on its biological functions in human thyroid carcinoma cells.

Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases.

Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks.

High sensitivity of intestinal CD8+ T cells to nucleotides indicates P2X7 as a regulator for intestinal T cell responses.

ATP induces P2X7 receptor-independent cytokine and chemokine expression through P2X1 and P2X3 receptors in murine mast cells.

Emerging roles of NAD+ and its metabolites in cell signaling.

NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells.

Characterisation of the R276A gain-of-function mutation in the ectodomain of murine P2X7.

Activation of the P2X7 ion channel by soluble and covalently bound ligands.

Basal and inducible expression of the thiol-sensitive ART2.1 ecto-ADP-ribosyltransferase in myeloid and lymphoid leukocytes.

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity.

Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells.

Proinflammatory and osteoclastogenic effects of beta-tricalciumphosphate and hydroxyapatite particles on human mononuclear cells in vitro.

Quantitative magnetic resonance imaging of enzyme activity on the cell surface: in vitro and in vivo monitoring of ADP-ribosyltransferase 2 on T cells.

ADP-ribosylation of arginine.

Single-domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP-ribosylating toxin of Salmonella typhimurium.

Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.

Compartmentation of NAD+-dependent signalling.

Characterisation of a novel glycosylphosphatidylinositol-anchored mono-ADP-ribosyltransferase isoform in ovary cells.

Transgenic overexpression of toxin-related ecto-ADP-ribosyltransferase ART2.2 sensitizes T cells but not B cells to NAD-induced cell death.

Strategies for the identification of arginine ADP-ribosylation sites.

Monoclonal antibodies for the identification and purification of vNAR domains and IgNAR immunoglobulins from the horn shark Heterodontus francisci.

Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail.

Patients with multiple myeloma develop SOX2-specific autoantibodies after allogeneic stem cell transplantation.

Antigen-specificity of oligoclonal abnormal protein bands in multiple myeloma after allogeneic stem cell transplantation.

Protective role for CCR5 in murine lupus nephritis.

Longitudinal analysis of tetanus- and influenza-specific IgG antibodies in myeloma patients.

Extracellular NAD(+): a danger signal hindering regulatory T cells.

Alternative splicing of the N-terminal cytosolic and transmembrane domains of P2X7 controls gating of the ion channel by ADP-ribosylation.

Expansion of HIV-specific T follicular helper cells in chronic HIV infection.

Cytokine concentrations and regulatory T cells in living donor and deceased donor liver transplant recipients.

CD8-β ADP-ribosylation affects CD8(+) T-cell function.

The art of blocking ADP-ribosyltransferases (ARTs): nanobodies as experimental and therapeutic tools to block mammalian and toxin ARTs.

CD38 controls the innate immune response against Listeria monocytogenes.

Peripheral blood biomarkers for the characterization of alloimmune reactivity after pediatric liver transplantation.

Technical Advance: a new cell preparation strategy that greatly improves the yield of vital and functional Tregs and NKT cells.

Mucolipidosis II-related mutations inhibit the exit from the endoplasmic reticulum and proteolytic cleavage of GlcNAc-1-phosphotransferase precursor protein (GNPTAB).

In vivo near-infrared fluorescence targeting of T cells: comparison of nanobodies and conventional monoclonal antibodies.

Multidimensional scaling analysis identifies pathological and prognostically relevant profiles of circulating T-cells in chronic lymphocytic leukemia.

ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells.

Functional autoantibodies against SSX-2 and NY-ESO-1 in multiple myeloma patients after allogeneic stem cell transplantation.

Identification and analysis of ADP-ribosylated proteins.

Function of the Th17/interleukin-17A immune response in murine lupus nephritis.

Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary Clostridium difficile toxin CDT.

The expression of CD39 on regulatory T cells is genetically driven and further upregulated at sites of inflammation.

Tuning IL-2 signaling by ADP-ribosylation of CD25.