John C. Schimenti

Department of Biomedical Sciences, Cornell University

Research Area

Developmental Biology

Biography

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JoVE Journal Publications

Article Total : 1	Year
Publication title	2018

Other Publications

Article	Year
The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm. Molecular and cellular biology\| PubMed ID: 15542845	2004
Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations. Genome research\| PubMed ID: 16024820	2005
The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation. The EMBO journal\| PubMed ID: 16222339	2005
Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations. Genetics\| PubMed ID: 17151244	2007
A dominant, recombination-defective allele of Dmc1 causing male-specific sterility. PLoS biology\| PubMed ID: 17425408	2007
Different regulatory systems operate in the midpiece and principal piece of the mammalian sperm flagellum. Society of Reproduction and Fertility supplement\| PubMed ID: 17644973	2007
Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis. PLoS genetics\| PubMed ID: 17696610	2007
Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic crossing over. PLoS genetics\| PubMed ID: 17784788	2007
The dual bromodomain and WD repeat-containing mouse protein BRWD1 is required for normal spermiogenesis and the oocyte-embryo transition. Developmental biology\| PubMed ID: 18353305	2008
Development and use of DNA archives at veterinary teaching hospitals to investigate the genetic basis of disease in dogs. Journal of the American Veterinary Medical Association\| PubMed ID: 19119968	2009
Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass. BMC developmental biology\| PubMed ID: 19379485	2009
Aneuploidy and improved growth are coincident but not causal in a yeast cancer model. PLoS biology\| PubMed ID: 19636358	2009
SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells. BMC developmental biology\| PubMed ID: 20170518	2010
Deficiency of suppressor enhancer Lin12 1 like (SEL1L) in mice leads to systemic endoplasmic reticulum stress and embryonic lethality. The Journal of biological chemistry\| PubMed ID: 20197277	2010
An allele separating skeletal patterning and spermatogonial renewal functions of PLZF. BMC developmental biology\| PubMed ID: 20338044	2010
PDCD2 is essential for inner cell mass development and embryonic stem cell maintenance. Developmental biology\| PubMed ID: 20813103	2010
The full-length isoform of the mouse pleckstrin homology domain-interacting protein (PHIP) is required for postnatal growth. FEBS letters\| PubMed ID: 20816727	2010
Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress. PLoS genetics\| PubMed ID: 20838603	2010
High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5. BMC genetics\| PubMed ID: 21118569	2010
A reduction of licensed origins reveals strain-specific replication dynamics in mice. Mammalian genome : official journal of the International Mammalian Genome Society\| PubMed ID: 21611832	2011
A-MYB (MYBL1) transcription factor is a master regulator of male meiosis. Development (Cambridge, England)\| PubMed ID: 21750041	2011
Genetic evidence that synaptonemal complex axial elements govern recombination pathway choice in mice. Genetics\| PubMed ID: 21750255	2011
Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. Genes\| PubMed ID: 21779533	2010
Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21987787	2011
Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells. Biology of reproduction\| PubMed ID: 22011390	2012
Haploid embryonic stem cells and the dominance of recessive traits. Cell stem cell\| PubMed ID: 22136917	2011
Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis. PLoS genetics\| PubMed ID: 22346761	2012
MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans. The Journal of clinical investigation\| PubMed ID: 22354170	2012
Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells. Nucleic acids research\| PubMed ID: 22362746	2012
MARF1 regulates essential oogenic processes in mice. Science (New York, N.Y.)\| PubMed ID: 22442484	2012
Comparative oncogenomics implicates the neurofibromin 1 gene (NF1) as a breast cancer driver. Genetics\| PubMed ID: 22851646	2012
Genetic background affects induced pluripotent stem cell generation. Stem cell research & therapy\| PubMed ID: 22862934	2012
Genetics of meiosis and recombination in mice. International review of cell and molecular biology\| PubMed ID: 22878107	2012
Using genetic networks and homology to understand the evolution of phenotypic traits. Current genomics\| PubMed ID: 22942677	2012
Tissue-specific functional networks for prioritizing phenotype and disease genes. PLoS computational biology\| PubMed ID: 23028291	2012
Meiosis arrest female 1 (MARF1) has nuage-like function in mammalian oocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23090997	2012
Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility. PLoS genetics\| PubMed ID: 23133405	2012
The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination. Molecular and cellular biology\| PubMed ID: 23401855	2013
An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Molecular cell\| PubMed ID: 23523368	2013
AKAP9 is essential for spermatogenesis and sertoli cell maturation in mice. Genetics\| PubMed ID: 23608191	2013
Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress. Oncogene\| PubMed ID: 23975433	2014
Female mice lacking estrogen receptor-alpha in osteoblasts have compromised bone mass and strength. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 24038209	2014
IQ motif-containing G (Iqcg) is required for mouse spermiogenesis. G3 (Bethesda, Md.)\| PubMed ID: 24362311	2014
Reversal of female infertility by Chk2 ablation reveals the oocyte DNA damage checkpoint pathway. Science (New York, N.Y.)\| PubMed ID: 24482479	2014
STAG3 is a strong candidate gene for male infertility. Human molecular genetics\| PubMed ID: 24608227	2014
miR-34 cooperates with p53 in suppression of prostate cancer by joint regulation of stem cell compartment. Cell reports\| PubMed ID: 24630988	2014
Induced pluripotent stem cells have similar immunogenic and more potent immunomodulatory properties compared with bone marrow-derived stromal cells in vitro. Regenerative medicine\| PubMed ID: 24773530	2014
Applying "gold standards" to in-vitro-derived germ cells. Cell\| PubMed ID: 24906145	2014
Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signaling. PLoS genetics\| PubMed ID: 25010009	2014
A method for isolating high quality RNA from mouse cortical and cancellous bone. Bone\| PubMed ID: 25073031	2014
A mouse geneticist's practical guide to CRISPR applications. Genetics\| PubMed ID: 25271304	2015
Mouse BRWD1 is critical for spermatid postmeiotic transcription and female meiotic chromosome stability. The Journal of cell biology\| PubMed ID: 25547156	2015
Effects of Deletion of ERα in Osteoblast-Lineage Cells on Bone Mass and Adaptation to Mechanical Loading Differ in Female and Male Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 25707500	2015
Mechanism and regulation of rapid telomere prophase movements in mouse meiotic chromosomes. Cell reports\| PubMed ID: 25892231	2015
The genetics of human infertility by functional interrogation of SNPs in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26240362	2015
MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway. Genesis (New York, N.Y. : 2000)\| PubMed ID: 26388201	2015
Chronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation. PLoS genetics\| PubMed ID: 26765334	2016
Transcriptional profiling of cortical versus cancellous bone from mechanically-loaded murine tibiae reveals differential gene expression. Bone\| PubMed ID: 26876048	2016
L. C. Dunn and Donald Charles on Quantitative Traits in the Mouse. Genetics\| PubMed ID: 26953264	2016
The Chromatin Remodeling Component Arid1a Is a Suppressor of Spontaneous Mammary Tumors in Mice. Genetics\| PubMed ID: 27280691	2016
Repair of Meiotic DNA Breaks and Homolog Pairing in Mouse Meiosis Requires a Minichromosome Maintenance (MCM) Paralog. Genetics\| PubMed ID: 27986806	2017
Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death. Genetics\| PubMed ID: 28576861	2017
The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure. Molecular cell\| PubMed ID: 28844861	2017