Shigeyoshi Itohara

Laboratory of Behavioral Genetics, RIKEN

Affiliated withRIKEN

Research Area

Behavior

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title	2018
Publication title	2018

Other Publications

Article	Year
Dynamic characteristics and adaptability of mouse vestibulo-ocular and optokinetic response eye movements and the role of the flocculo-olivary system revealed by chemical lesions. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9636214	1998
Inhibition of nitric oxide synthesis and gene knockout of neuronal nitric oxide synthase impaired adaptation of mouse optokinetic response eye movements. Learning & memory (Cold Spring Harbor, N.Y.)\| PubMed ID: 10940322	2000
Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex. Nature\| PubMed ID: 10963597	2000
Embryonic lethality of molecular chaperone hsp47 knockout mice is associated with defects in collagen biosynthesis. The Journal of cell biology\| PubMed ID: 10995453	2000
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nature cell biology\| PubMed ID: 11025665	2000
Complementary expression and neurite outgrowth activity of netrin-G subfamily members. Mechanisms of development\| PubMed ID: 11804778	2002
Transgenic mice expressing a pH and Cl- sensing yellow-fluorescent protein under the control of a potassium channel promoter. The European journal of neuroscience\| PubMed ID: 11860505	2002
Normal development of serotonergic neurons in mice lacking S100B. Neuroscience letters\| PubMed ID: 11872254	2002
Glial protein S100B modulates long-term neuronal synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11891290	2002
Distribution of phosphorylated glial fibrillary acidic protein in the mouse central nervous system. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 11918673	2002
Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice. Human molecular genetics\| PubMed ID: 12019206	2002
Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12177195	2002
In vivo glioma growth requires host-derived matrix metalloproteinase 2 for maintenance of angioarchitecture. Pharmacological research\| PubMed ID: 12220955	2002
Lesion-induced thalamocortical axonal plasticity in the S1 cortex is independent of NMDA receptor function in excitatory cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 12417641	2002
NMDA receptor-dependent pattern transfer from afferents to postsynaptic cells and dendritic differentiation in the barrel cortex. Molecular and cellular neurosciences\| PubMed ID: 12498788	2002
Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus. Cell and tissue research\| PubMed ID: 14605869	2004
Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality. The Journal of biological chemistry\| PubMed ID: 14645240	2004
The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model. The EMBO journal\| PubMed ID: 14657037	2003
Stimulus-induced behavior in F1 hybrids of seizure-sensitive and seizure-resistant gerbils. Zoological science\| PubMed ID: 14709808	2003
Dorsal telencephalon-specific expression of Cre recombinase in PAC transgenic mice. Genesis (New York, N.Y. : 2000)\| PubMed ID: 15048810	2004
BMPR1A signaling is necessary for hair follicle cycling and hair shaft differentiation in mice. Development (Cambridge, England)\| PubMed ID: 15084466	2004
Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives. Developmental biology\| PubMed ID: 15136147	2004
Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model. Human molecular genetics\| PubMed ID: 15294873	2004
Laminar organization of the developing lateral olfactory tract revealed by differential expression of cell recognition molecules. The Journal of comparative neurology\| PubMed ID: 15457507	2004
Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice. The Journal of biological chemistry\| PubMed ID: 15691848	2005
Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors. The Journal of biological chemistry\| PubMed ID: 15699033	2005
A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia. Biological psychiatry\| PubMed ID: 15705354	2005
Exuberant thalamocortical axon arborization in cortex-specific NMDAR1 knockout mice. The Journal of comparative neurology\| PubMed ID: 15803506	2005
Human netrin-G1 isoforms show evidence of differential expression. Genomics\| PubMed ID: 15901489	2005
Molecular evidence for two-stage learning and partial laterality in eyeblink conditioning of mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16569693	2006
High-efficiency CAG-FLPe deleter mice in C57BL/6J background. Experimental animals\| PubMed ID: 16651697	2006
Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells. Genes to cells : devoted to molecular & cellular mechanisms\| PubMed ID: 16716193	2006
Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice. Neurobiology of disease\| PubMed ID: 16956767	2006
A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism. The Journal of biological chemistry\| PubMed ID: 16959767	2006
Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP. PloS one\| PubMed ID: 17183681	2006
Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway. Molecular and cellular biology\| PubMed ID: 17283058	2007
Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation. Molecular and cellular biology\| PubMed ID: 17296732	2007
Impact of S100B on local field potential patterns in anesthetized and kainic acid-induced seizure conditions in vivo. The European journal of neuroscience\| PubMed ID: 17331210	2007
Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17344385	2007
Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients. The Journal of clinical investigation\| PubMed ID: 17380209	2007
GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17409249	2007
Role of matrix metalloproteinase and tissue inhibitor of MMP in methamphetamine-induced behavioral sensitization and reward: implications for dopamine receptor down-regulation and dopamine r... Journal of neurochemistry\| PubMed ID: 17472698	2007
Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex. Development (Cambridge, England)\| PubMed ID: 17507397	2007
Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 17537961	2007
Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. Cell\| PubMed ID: 17719550	2007
Axonal netrin-Gs transneuronally determine lamina-specific subdendritic segments. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 17785411	2007
Genetic ablation of NMDA receptor subunit NR3B in mouse reveals motoneuronal and nonmotoneuronal phenotypes. The European journal of neuroscience\| PubMed ID: 17880385	2007
Pael receptor is involved in dopamine metabolism in the nigrostriatal system. Neuroscience research\| PubMed ID: 17889953	2007
Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. The Journal of clinical investigation\| PubMed ID: 18172552	2008
GABA and synaptic inhibition of mouse cerebellum lacking glutamate decarboxylase 67. Biochemical and biophysical research communications\| PubMed ID: 18384748	2008
Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion. Archives of biochemistry and biophysics\| PubMed ID: 18477466	2008
BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier. Molecular and cellular neurosciences\| PubMed ID: 18501628	2008
Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18524897	2008
Neural-activity-dependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 18945900	2008
Lack of Connexin43-mediated bergmann glial gap junctional coupling does not affect cerebellar long-term depression, motor coordination, or eyeblink conditioning. Frontiers in behavioral neuroscience\| PubMed ID: 18958191	2008
A novel form of memory for auditory fear conditioning at a low-intensity unconditioned stimulus. PloS one\| PubMed ID: 19132103	2009
Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. Human molecular genetics\| PubMed ID: 19147686	2009
Dual involvement of G-substrate in motor learning revealed by gene deletion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 19218432	2009
Connexin43 and bergmann glial gap junctions in cerebellar function. Frontiers in neuroscience\| PubMed ID: 19225596	2008
DSCAM deficiency causes loss of pre-inspiratory neuron synchroneity and perinatal death. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19261893	2009
Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1. Neuroscience\| PubMed ID: 19332109	2009
X11-like protein deficiency is associated with impaired conflict resolution in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 19420255	2009
Tracing conformational transition of abnormal prion proteins during interspecies transmission by using novel antibodies. The Journal of biological chemistry\| PubMed ID: 20177064	2010
Role of mouse hepatitis virus (MHV) receptor murine CEACAM1 in the resistance of mice to MHV infection: studies of mice with chimeric mCEACAM1a and mCEACAM1b. Journal of virology\| PubMed ID: 20410265	2010
Involvement of cyclin-dependent kinase-like 2 in cognitive function required for contextual and spatial learning in mice. Frontiers in behavioral neuroscience\| PubMed ID: 20428496	2010
Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain. The Journal of biological chemistry\| PubMed ID: 20966073	2010
Normal delay eyeblink conditioning in mice devoid of astrocytic S100B. Neuroscience letters\| PubMed ID: 21146588	2011
Identification of a novel intronic enhancer responsible for the transcriptional regulation of musashi1 in neural stem/progenitor cells. Molecular brain\| PubMed ID: 21486496	2011
NMDA receptors in hippocampal GABAergic synapses and their role in nitric oxide signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21508214	2011
Role of adenylate cyclase 1 in retinofugal map development. The Journal of comparative neurology\| PubMed ID: 22102330	2011
Restoration of contralateral representation in the mouse somatosensory cortex after crossing nerve transfer. PloS one\| PubMed ID: 22536423	2012
S100B is increased in Parkinson's disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway. Brain : a journal of neurology\| PubMed ID: 23169921	2012
Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23213205	2012
The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs. Biology open\| PubMed ID: 23213437	2012
Astrocytic Ca2+ signals are required for the functional integrity of tripartite synapses. Molecular brain\| PubMed ID: 23356992	2013
Genetic dissection of medial habenula-interpeduncular nucleus pathway function in mice. Frontiers in behavioral neuroscience\| PubMed ID: 23487260	2013
Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production. Molecular and cellular biology\| PubMed ID: 23689133	2013
Optogenetic dissection reveals multiple rhythmogenic modules underlying locomotion. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23798384	2013
Nav1.1 haploinsufficiency in excitatory neurons ameliorates seizure-associated sudden death in a mouse model of Dravet syndrome. Human molecular genetics\| PubMed ID: 23922229	2013
Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells. The Journal of biological chemistry\| PubMed ID: 24142690	2013
CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24174665	2013
Polycomb potentiates meis2 activation in midbrain by mediating interaction of the promoter with a tissue-specific enhancer. Developmental cell\| PubMed ID: 24374176	2014
Spatiotemporal calcium dynamics in single astrocytes and its modulation by neuronal activity. Cell calcium\| PubMed ID: 24484772	2014
Spinal glutamatergic neurons defined by EphA4 signaling are essential components of normal locomotor circuits. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 24623763	2014
Identification of transcriptional regulatory elements for Ntng1 and Ntng2 genes in mice. Molecular brain\| PubMed ID: 24642214	2014
NMDAR-regulated dynamics of layer 4 neuronal dendrites during thalamocortical reorganization in neonates. Neuron\| PubMed ID: 24685175	2014
Single App knock-in mouse models of Alzheimer's disease. Nature neuroscience\| PubMed ID: 24728269	2014
Regulatory factor X transcription factors control Musashi1 transcription in mouse neural stem/progenitor cells. Stem cells and development\| PubMed ID: 25058468	2014
RacGAP α2-chimaerin function in development adjusts cognitive ability in adulthood. Cell reports\| PubMed ID: 25159148	2014
Thalamic NMDA receptor function is necessary for patterning of the thalamocortical somatosensory map and for sensorimotor behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25186746	2014
Cdk5/p35 functions as a crucial regulator of spatial learning and memory. Molecular brain\| PubMed ID: 25404232	2014
Netrin-G/NGL complexes encode functional synaptic diversification. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25411505	2014
Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25904796	2015
Involvement of cAMP-guanine nucleotide exchange factor II in hippocampal long-term depression and behavioral flexibility. Molecular brain\| PubMed ID: 26104314	2015
S100B Up-Regulates Macrophage Production of IL1β and CCL22 and Influences Severity of Retinal Inflammation. PloS one\| PubMed ID: 26204512	2015
Supersensitive detection and discrimination of enantiomers by dorsal olfactory receptors: evidence for hierarchical odour coding. Scientific reports\| PubMed ID: 26361056	2015
Developmental RacGAP α2-Chimaerin Signaling Is a Determinant of the Morphological Features of Dendritic Spines in Adulthood. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26446225	2015
Cells of a common developmental origin regulate REM/non-REM sleep and wakefulness in mice. Science (New York, N.Y.)\| PubMed ID: 26494173	2015
Diversification of behavior and postsynaptic properties by netrin-G presynaptic adhesion family proteins. Molecular brain\| PubMed ID: 26746425	2016
Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26888934	2016
Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain. Nature communications\| PubMed ID: 27000523	2016
Netrin-G1 regulates fear-like and anxiety-like behaviors in dissociable neural circuits. Scientific reports\| PubMed ID: 27345935	2016
Cognitive deficits in single App knock-in mouse models. Neurobiology of learning and memory\| PubMed ID: 27377630	2016
CAPS1 stabilizes the state of readily releasable synaptic vesicles to fusion competence at CA3-CA1 synapses in adult hippocampus. Scientific reports\| PubMed ID: 27545744	2016
Reassessment of long-term depression in cerebellar Purkinje cells in mice carrying mutated GluA2 C terminus. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 27551099	2016
Editorial. Neurobiology of learning and memory\| PubMed ID: 27593356	2016
Ventral CA1 neurons store social memory. Science (New York, N.Y.)\| PubMed ID: 27708103	2016
Antagonistic negative and positive neurons of the basolateral amygdala. Nature neuroscience\| PubMed ID: 27749826	2016
Supernova: A Versatile Vector System for Single-Cell Labeling and Gene Function Studies in vivo. Scientific reports\| PubMed ID: 27775045	2016
Mammalian-Specific Central Myelin Protein Opalin Is Redundant for Normal Myelination: Structural and Behavioral Assessments. PloS one\| PubMed ID: 27855200	2016
Cutting-edge approaches to unwrapping the mysteries of sleep. Neuroscience research\| PubMed ID: 28622895	2017
Spinal RacGAP α-Chimaerin Is Required to Establish the Midline Barrier for Proper Corticospinal Axon Guidance. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 28747385	2017
The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways. The Journal of biological chemistry\| PubMed ID: 28784662	2017
Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma. EBioMedicine\| PubMed ID: 28928015	2017
Potentiation of excitatory synaptic transmission ameliorates aggression in mice with Stxbp1 haploinsufficiency. Human molecular genetics\| PubMed ID: 29040524	2017
Excitatory Neuronal Hubs Configure Multisensory Integration of Slow Waves in Association Cortex. Cell reports\| PubMed ID: 29539417	2018
Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder. Molecular psychiatry\| PubMed ID: 29892051	2018