Annet Kirabo

Division of Clinical Pharmacology, Vanderbilt University Medical Center

Affiliated withVanderbilt University Medical Center Vanderbilt University

Research Area

Immunology and InfectionBiology

Biography

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JoVE Journal Publications

ArticleTotal : 3	Year
Publication title	2019
Publication title	2021
Publication title	2023

Other Publications

Article	Year
DC isoketal-modified proteins activate T cells and promote hypertension. The Journal of clinical investigation\| PubMed ID: 25244096	2014
Immune activation caused by vascular oxidation promotes fibrosis and hypertension. The Journal of clinical investigation\| PubMed ID: 26595812	2016
CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli. Circulation research\| PubMed ID: 26988069	2016
Do high-salt microenvironments drive hypertensive inflammation? American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 27903514	2017
Dendritic cells and isolevuglandins in immunity, inflammation, and hypertension. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 27986660	2017
Neuregulin-1β induces proliferation, survival and paracrine signaling in normal human cardiac ventricular fibroblasts. Journal of molecular and cellular cardiology\| PubMed ID: 28263756	2017
A New Role of Mister (MR) T in Hypertension: Mineralocorticoid Receptor, Immune System, and Hypertension. Circulation research\| PubMed ID: 28495982	2017
A new paradigm of sodium regulation in inflammation and hypertension. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 28931546	2017
Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension. Cell reports\| PubMed ID: 29069584	2017
High CD8 T-Cell Receptor Clonality and Altered CDR3 Properties Are Associated With Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity. Diabetes\| PubMed ID: 30181158	2018
Mechanisms of isolevuglandin-protein adduct formation in inflammation and hypertension. Prostaglandins & other lipid mediators\| PubMed ID: 30278231	2018
High dietary salt-induced dendritic cell activation underlies microbial dysbiosis-associated hypertension. JCI insight\| PubMed ID: 31162138	2019
Patho-immune Mechanisms of Hypertension in HIV: a Systematic and Thematic Review. Current hypertension reports\| PubMed ID: 31165257	2019
High Salt Activates CD11c Antigen-Presenting Cells via SGK (Serum Glucocorticoid Kinase) 1 to Promote Renal Inflammation and Salt-Sensitive Hypertension. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 31280647	2019
HIV, immune activation and salt-sensitive hypertension (HISH): a research proposal. BMC research notes\| PubMed ID: 31311574	2019
Dendritic Cell A20: Targeting Hypertension in Autoimmunity. Circulation research\| PubMed ID: 31804913	2019
Elevated Eosinophils as a Feature of Inflammation Associated With Hypertension in Virally Suppressed People Living With HIV. Journal of the American Heart Association\| PubMed ID: 32064996	2020
From Rags to Riches: Moving Beyond RAG1 in Studies of Hypertension. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 32078385	2020
Blood pressure, T cells, and mortality in people with HIV in Tanzania during the first 2 years of antiretroviral therapy. Journal of clinical hypertension (Greenwich, Conn.)\| PubMed ID: 32815636	2020
ENaC in Salt-Sensitive Hypertension: Kidney and Beyond. Current hypertension reports\| PubMed ID: 32852643	2020
The Gut Microbiome, Inflammation, and Salt-Sensitive Hypertension. Current hypertension reports\| PubMed ID: 32880753	2020
Hypertension and Metabolic Syndrome in Persons with HIV. Current hypertension reports\| PubMed ID: 32880756	2020
Sodium activates human monocytes via the NADPH oxidase and isolevuglandin formation. Cardiovascular research\| PubMed ID: 33038226	2021
The role of inflammation in hypertension: novel concepts. Current opinion in physiology\| PubMed ID: 33073072	2021
HIV-positive demonstrate more salt sensitivity and nocturnal non-dipping blood pressure than HIV-negative individuals. Clinical hypertension\| PubMed ID: 33446278	2021
Isolevuglandin-Modified Cardiac Proteins Drive CD4+ T-Cell Activation in the Heart and Promote Cardiac Dysfunction. Circulation\| PubMed ID: 33463362	2021
Hypertension: Do Inflammation and Immunity Hold the Key to Solving this Epidemic? Circulation research\| PubMed ID: 33793336	2021
Kidney injury-mediated disruption of intestinal lymphatics involves dicarbonyl-modified lipoproteins. Kidney international\| PubMed ID: 34102217	2021
Inflammation, immunity, and hypertensive end-organ damage. Circulation research\| PubMed ID: 25767287	2015
Inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 mitogen-activated protein kinase. Circulation research\| PubMed ID: 24347665	2014
Oligoclonal CD8+ T cells play a critical role in the development of hypertension. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 25259750	2014
Renal transporter activation during angiotensin-II hypertension is blunted in interferon-γ-/- and interleukin-17A-/- mice. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 25601932	2015
Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation. The Journal of clinical investigation\| PubMed ID: 25664851	2015
Renal Denervation Prevents Immune Cell Activation and Renal Inflammation in Angiotensin II-Induced Hypertension. Circulation research\| PubMed ID: 26156232	2015
Isolevuglandins as mediators of disease and the development of dicarbonyl scavengers as pharmaceutical interventions. Pharmacology & therapeutics\| PubMed ID: 31629006	2020
Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension. JACC. Basic to translational science\| PubMed ID: 32613146	2020
New Insights Into the Renin-Angiotensin System in Chronic Kidney Disease. Circulation research\| PubMed ID: 32790525	2020
Scavenging Reactive Lipids to Prevent Oxidative Injury. Annual review of pharmacology and toxicology\| PubMed ID: 32997599	2021
Hypothesis: Unrecognized actions of ENaC blockade in improving refractory-resistant hypertension and residual cardiovascular risk. International Journal of Cardiology. Hypertension\| PubMed ID: 33447773	2020
Epithelial Sodium Channel and Salt-Sensitive Hypertension. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 33486988	2021
Immune Mechanisms of Dietary Salt-Induced Hypertension and Kidney Disease: Harry Goldblatt Award for Early Career Investigators 2020. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 34232678	2021
Salt Sensitivity of Blood Pressure in Blacks and Women: A Role of Inflammation, Oxidative Stress, and Epithelial Na Channel. Antioxidants & redox signaling\| PubMed ID: 34569287	2021
Salt sensitivity of volume and blood pressure in a mouse with globally reduced ENaC γ-subunit expression. American journal of physiology. Renal physiology\| PubMed ID: 34632813	2021
Salt-Sensitivity of Blood Pressure and Insulin Resistance. Frontiers in physiology\| PubMed ID: 34966295	2021
Sox6, A Potential Target for MicroRNAs in Cardiometabolic Disease. Current hypertension reports\| PubMed ID: 35124768	2022
Kidney Injury Causes Accumulation of Renal Sodium That Modulates Renal Lymphatic Dynamics. International journal of molecular sciences\| PubMed ID: 35163352	2022
Bile acids and salt-sensitive hypertension: a role of the gut-liver axis. American journal of physiology. Heart and circulatory physiology\| PubMed ID: 35245132	2022
Emerging Roles for G Protein-Coupled Estrogen Receptor 1 in Cardio-Renal Health: Implications for Aging. Biomolecules\| PubMed ID: 35327604	2022
Hypersensitive or hypertensive? IgE-FcɛR1 signalling in mast cells adds a new piece to the immunity and hypertension puzzle. Cardiovascular research\| PubMed ID: 35417016	2022
Recent advances in modulation of cardiovascular diseases by the gut microbiota. Journal of human hypertension\| PubMed ID: 35469059	2022
Isolevuglandins disrupt PU.1-mediated C1q expression and promote autoimmunity and hypertension in systemic lupus erythematosus. JCI insight\| PubMed ID: 35608913	2022
Enhanced parasympathetic cholinergic activity with galantamine inhibited lipid-induced oxidative stress in obese African Americans. Molecular medicine (Cambridge, Mass.)\| PubMed ID: 35659521	2022
Inflammation, Lymphatics, and Cardiovascular Disease: Amplification by Chronic Kidney Disease. Current hypertension reports\| PubMed ID: 35727522	2022
The Gut Microbiota and Short-Chain Fatty Acids Profile in Postural Orthostatic Tachycardia Syndrome. Frontiers in physiology\| PubMed ID: 35733987	2022
Kidney Tubular IL-1β ENaCtivation in Diabetes and Salt-Sensitive Hypertension. Circulation research\| PubMed ID: 35737755	2022
DC ENaC-Dependent Inflammasome Activation Contributes to Salt-Sensitive Hypertension. Circulation research\| PubMed ID: 35862128	2022
Hypertension and human immunodeficiency virus: A paradigm for epithelial sodium channels? Frontiers in cardiovascular medicine\| PubMed ID: 36093171	2022
Immediate pressor response to oral salt and its assessment in the clinic: a time series clinical trial. Clinical hypertension\| PubMed ID: 36104796	2022
Dicarbonyl-modified lipoproteins contribute to proteinuric kidney injury. JCI insight\| PubMed ID: 36125905	2022
Rare Variants in Genes Encoding Subunits of the Epithelial Na Channel Are Associated With Blood Pressure and Kidney Function. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 36193739	2022
Dendritic Cell Epithelial Sodium Channel in Inflammation, Salt-Sensitive Hypertension, and Kidney Damage. Kidney360\| PubMed ID: 36245645	2022
Sex differences in hypertension among people living with HIV after initiation of antiretroviral therapy. Frontiers in cardiovascular medicine\| PubMed ID: 36465432	2022
In Memoriam: Fernando Elijovich. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 36475860	2023
Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome. Frontiers in physiology\| PubMed ID: 36620210	2022
Salt Taste and Salt Sensitive Hypertension in HIV. Current hypertension reports\| PubMed ID: 36800166	2023
Post-COVID-19 Afferent Baroreflex Failure. Hypertension (Dallas, Tex. : 1979)\| PubMed ID: 36802914	2023
Meet the Novel Players in Hypertensive Kidney Disease: Septin4 and SIRT2. Circulation research\| PubMed ID: 36862813	2023
Novel Concepts in Nephron Sodium Transport: A Physiological and Clinical Perspective. Advances in kidney disease and health\| PubMed ID: 36868728	2023
βARs: double edge sword in heart function. Trends in molecular medicine\| PubMed ID: 36990857	2023
Gut microbiota dependant trimethylamine N-oxide and hypertension. Frontiers in physiology\| PubMed ID: 37089429	2023
Intestinal Lymphatic Dysfunction in Kidney Disease. Circulation research\| PubMed ID: 37104557	2023
The epithelial sodium channel in inflammation and blood pressure modulation. Frontiers in cardiovascular medicine\| PubMed ID: 37123470	2023
Mechanisms of Oxidative Stress in Metabolic Syndrome. International journal of molecular sciences\| PubMed ID: 37175603	2023
Salt and Gut Microbiota in Heart Failure. Current hypertension reports\| PubMed ID: 37219766	2023