Department of Orthopedic Surgery,
Department of Biomedical Engineering
Iden Kurtaliaj is a doctoral candidate in Biomedical Engineering at Columbia University. She graduated with honors, distinction and magna cum laude from Drexel University, where she completed the dual BS/MS accelerated degree program in Biomedical Engineering. During her undergraduate studies, she completed three, six-month internships and gained experience in product development. During these internships, she designed, prototyped, and brought to market numerous medical devices, including a spinal implant, for which she is first author of the patent. A desire to merge her passions of engineering, translational research and medical innovation to improve individual and global health, brought her to Columbia University to pursue a MS in Mechanical Engineering. Drawn by the prevalence of poor outcomes after rotator cuff repair and its potential for translational research, she then joined Dr. Thomopoulos Laborotory to pursue a PhD. Her research focuses on innovative solutions to improve fixation of tendon to bone during rotator cuff repair by improving load distribution across the repair site.
Contribution of extracellular matrix to the mechanical properties of the heart.
Journal of molecular and cellular cardiology Mar, 2010 | Pubmed ID: 19686759
Functional attachment of soft tissues to bone: development, healing, and tissue engineering.
Annual review of biomedical engineering , 2013 | Pubmed ID: 23642244
Allometry of the Tendon Enthesis: Mechanisms of Load Transfer Between Tendon and Bone.
Journal of biomechanical engineering Nov, 2015 | Pubmed ID: 26355607
In Vivo Evaluation of Adipose-Derived Stromal Cells Delivered with a Nanofiber Scaffold for Tendon-to-Bone Repair.
Tissue engineering. Part A Nov, 2015 | Pubmed ID: 26414599
Scleraxis is required for the development of a functional tendon enthesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jan, 2016 | Pubmed ID: 26443819
Effect of adipose-derived stromal cells and BMP12 on intrasynovial tendon repair: A biomechanical, biochemical, and proteomics study.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Apr, 2016 | Pubmed ID: 26445383
Tunability of collagen matrix mechanical properties via multiple modes of mineralization.
Interface focus Feb, 2016 | Pubmed ID: 26855755
Surgical Sutures with Porous Sheaths for the Sustained Release of Growth Factors.
Advanced materials (Deerfield Beach, Fla.) Jun, 2016 | Pubmed ID: 27059654
Enhanced Zone II Flexor Tendon Repair through a New Half Hitch Loop Suture Configuration.
PloS one , 2016 | Pubmed ID: 27101409
The concentration of stress at the rotator cuff tendon-to-bone attachment site is conserved across species.
Journal of the mechanical behavior of biomedical materials 09, 2016 | Pubmed ID: 27161959
Effects of imbalanced muscle loading on hip joint development and maturation.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 05, 2017 | Pubmed ID: 27391299
The effect of mesenchymal stromal cell sheets on the inflammatory stage of flexor tendon healing.
Stem cell research & therapy Sep, 2016 | Pubmed ID: 27677963
Introduction.
Connective tissue research 11, 2016 | Pubmed ID: 27753517
Evaluation of Calcium Phosphate Nucleation Kinetics and Pathways during Intra- and Extrafibrillar Mineralization of Collagen Matrices.
Crystal growth & design , 2016 | Pubmed ID: 27891066
Cell and Biologic-Based Treatment of Flexor Tendon Injuries.
Operative techniques in orthopaedics Sep, 2016 | Pubmed ID: 28042226
Micro-mechanical properties of the tendon-to-bone attachment.
Acta biomaterialia 07, 2017 | Pubmed ID: 28088669
Enthesis regeneration: a role for Gli1+ progenitor cells.
Development (Cambridge, England) 04, 2017 | Pubmed ID: 28219952
Protein-free formation of bone-like apatite: New insights into the key role of carbonation.
Biomaterials 05, 2017 | Pubmed ID: 28279923
Combined Administration of ASCs and BMP-12 Promotes an M2 Macrophage Phenotype and Enhances Tendon Healing.
Clinical orthopaedics and related research Sep, 2017 | Pubmed ID: 28462460
Rotator cuff muscle degeneration and tear severity related to myogenic, adipogenic, and atrophy genes in human muscle.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 12, 2017 | Pubmed ID: 28470887
Sclerostin Antibody Treatment Enhances Rotator Cuff Tendon-to-Bone Healing in an Animal Model.
The Journal of bone and joint surgery. American volume May, 2017 | Pubmed ID: 28509826
Toughening of fibrous scaffolds by mobile mineral deposits.
Acta biomaterialia 08, 2017 | Pubmed ID: 28532898
The tendon-to-bone attachment: Unification through disarray.
Nature materials 05, 2017 | Pubmed ID: 28541313
The fibrous cellular microenvironment, and how cells make sense of a tangled web.
Proceedings of the National Academy of Sciences of the United States of America 06, 2017 | Pubmed ID: 28550106
Effects of spaceflight on the muscles of the murine shoulder.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 12, 2017 | Pubmed ID: 28821629
Targeting Inflammation in Rotator Cuff Tendon Degeneration and Repair.
Techniques in shoulder & elbow surgery Sep, 2017 | Pubmed ID: 28947893
Integrating soft and hard tissues via interface tissue engineering.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 04, 2018 | Pubmed ID: 29149506
Effect of connective tissue growth factor delivered via porous sutures on the proliferative stage of intrasynovial tendon repair.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 07, 2018 | Pubmed ID: 29266404
Enhanced tendon-to-bone repair through adhesive films.
Acta biomaterialia 04, 2018 | Pubmed ID: 29427745
The role of confined collagen geometry in decreasing nucleation energy barriers to intrafibrillar mineralization.
Nature communications 03, 2018 | Pubmed ID: 29511184
Design and Fabrication of a Hierarchically Structured Scaffold for Tendon-to-Bone Repair.
Advanced materials (Deerfield Beach, Fla.) Apr, 2018 | Pubmed ID: 29534316
Inverse Opal Scaffolds with Gradations in Mineral Content for Spatial Control of Osteogenesis.
Advanced materials (Deerfield Beach, Fla.) May, 2018 | Pubmed ID: 29847696
Potential strain-dependent mechanisms defining matrix alignment in healing tendons.
Biomechanics and modeling in mechanobiology Dec, 2018 | Pubmed ID: 30003433
The effect of adipose-derived stem cell sheets and CTGF on early flexor tendon healing in a canine model.
Scientific reports 07, 2018 | Pubmed ID: 30038250
Enthesis Repair: Challenges and Opportunities for Effective Tendon-to-Bone Healing.
The Journal of bone and joint surgery. American volume Aug, 2018 | Pubmed ID: 30106830
Energy dissipation in mammalian collagen fibrils: Cyclic strain-induced damping, toughening, and strengthening.
Acta biomaterialia 10, 2018 | Pubmed ID: 30240954
Regularization-Free Strain Mapping in Three Dimensions, With Application to Cardiac Ultrasound.
Journal of biomechanical engineering Jan, 2019 | Pubmed ID: 30267039
The effect of modified locking methods and suture materials on Zone II flexor tendon repair-An ex vivo study.
PloS one , 2018 | Pubmed ID: 30289887
The multiscale structural and mechanical effects of mouse supraspinatus muscle unloading on the mature enthesis.
Acta biomaterialia 01, 2019 | Pubmed ID: 30342287
CTGF induces tenogenic differentiation and proliferation of adipose-derived stromal cells.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Mar, 2019 | Pubmed ID: 30756417
Targeting the NF-κB signaling pathway in chronic tendon disease.
Science translational medicine Feb, 2019 | Pubmed ID: 30814338
Adhesive-based tendon-to-bone repair: failure modelling and materials selection.
Journal of the Royal Society, Interface Apr, 2019 | Pubmed ID: 30966948
<i>In situ</i> tissue engineering of tendon-to-bone interface by endogenous stem/progenitor cells.
Biofabrication Sep, 2019 | Pubmed ID: 31561236
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