Adrian Goldman

Research Program in Molecular and Integrative Biosciences, University of Helsinki

Affiliated withUniversity of Helsinki University of Leeds

Research Area

Biochemistry

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title Cited by 6	2019

Other Publications

Article	Year
The structure of Neurospora crassa 3-carboxy-cis,cis-muconate lactonizing enzyme, a beta propeller cycloisomerase. Structure (London, England : 1993)\| PubMed ID: 11937053	2002
3-Carboxy-cis,cis-muconate lactonizing enzyme from Neurospora crassa: MAD phasing with 80 selenomethionines. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 11976482	2002
Expression, purification and crystallization of a collagen-binding fragment of Yersinia adhesin YadA. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 12037311	2002
Structure of Escherichia coli pyruvate formate-lyase with pyruvate. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 12454503	2002
Structural studies of Yersinia adhesin YadA. Advances in experimental medicine and biology\| PubMed ID: 12756733	2003
The structural basis of receptor-binding by Escherichia coli associated with diarrhea and septicemia. Journal of molecular biology\| PubMed ID: 12909017	2003
The structure of Pseudomonas P51 Cl-muconate lactonizing enzyme: co-evolution of structure and dynamics with the dehalogenation function. Protein science : a publication of the Protein Society\| PubMed ID: 12930985	2003
The Yersinia adhesin YadA collagen-binding domain structure is a novel left-handed parallel beta-roll. The EMBO journal\| PubMed ID: 14765110	2004
Functional expression and direct visualization of the human alpha 2B -adrenergic receptor and alpha 2B -AR-green fluorescent fusion protein in mammalian cell using Semliki Forest virus vecto... Protein expression and purification\| PubMed ID: 14965773	2003
The structure of GFRalpha1 domain 3 reveals new insights into GDNF binding and RET activation. The EMBO journal\| PubMed ID: 15044950	2004
Structural studies of metal ions in family II pyrophosphatases: the requirement for a Janus ion. Biochemistry\| PubMed ID: 15533045	2004
The first cysteine-rich domain of the receptor GFRalpha1 stabilizes the binding of GDNF. The Biochemical journal\| PubMed ID: 15610063	2005
Unusual twinning in an acetyl coenzyme A synthetase (ADP-forming) from Pyrococcus furiosus. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 15735347	2005
G protein-coupled receptors show unusual patterns of intrinsic unfolding. Protein engineering, design & selection : PEDS\| PubMed ID: 15790574	2005
The structure of the bacteriophage PRD1 spike sheds light on the evolution of viral capsid architecture. Molecular cell\| PubMed ID: 15837420	2005
Functional studies with membrane-bound and detergent-solubilized alpha2-adrenergic receptors expressed in Sf9 cells. Biochimica et biophysica acta\| PubMed ID: 15893292	2005
G-protein-coupled receptor domain overexpression in Halobacterium salinarum: long-range transmembrane interactions in heptahelical membrane proteins. Proteins\| PubMed ID: 15971205	2005
Intracellularly truncated human alpha2B-adrenoceptors: stable and functional GPCRs for structural studies. Journal of receptor and signal transduction research\| PubMed ID: 16149769	2005
Crystal structure of a glycyl radical enzyme from Archaeoglobus fulgidus. Journal of molecular biology\| PubMed ID: 16414072	2006
Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome. The EMBO journal\| PubMed ID: 16601698	2006
Crystallization and preliminary crystallographic analysis of two Streptococcus agalactiae proteins: the family II inorganic pyrophosphatase and the serine/threonine phosphatase. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 16946472	2006
Reindeer beta-lactoglobulin crystal structure with pseudo-body-centred noncrystallographic symmetry. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 17057340	2006
Crystal structure of the second PDZ domain of SAP97 in complex with a GluR-A C-terminal peptide. The FEBS journal\| PubMed ID: 17069616	2006
A trimetal site and substrate distortion in a family II inorganic pyrophosphatase. The Journal of biological chemistry\| PubMed ID: 17095506	2007
A complete structural description of the catalytic cycle of yeast pyrophosphatase. Biochemistry\| PubMed ID: 17260952	2007
Interactions with other human UDP-glucuronosyltransferases attenuate the consequences of the Y485D mutation on the activity and substrate affinity of UGT1A6. Pharmacogenetics and genomics\| PubMed ID: 17301691	2007
Structure of the Streptococcus agalactiae family II inorganic pyrophosphatase at 2.80 A resolution. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 17505113	2007
Structure of Streptococcus agalactiae serine/threonine phosphatase. The subdomain conformation is coupled to the binding of a third metal ion. The FEBS journal\| PubMed ID: 17521332	2007
Crystal structure of the N-terminal NC4 domain of collagen IX, a zinc binding member of the laminin-neurexin-sex hormone binding globulin (LNS) domain family. The Journal of biological chemistry\| PubMed ID: 17553797	2007
The human UDP-glucuronosyltransferase: identification of key residues within the nucleotide-sugar binding site. Molecular pharmacology\| PubMed ID: 17578897	2007
The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 18048489	2008
Mutation analysis in UGT1A9 suggests a relationship between substrate and catalytic residues in UDP-glucuronosyltransferases. Protein engineering, design & selection : PEDS\| PubMed ID: 18502788	2008
Structure of the actin-depolymerizing factor homology domain in complex with actin. The Journal of cell biology\| PubMed ID: 18625842	2008
The structure of the glial cell line-derived neurotrophic factor-coreceptor complex: insights into RET signaling and heparin binding. The Journal of biological chemistry\| PubMed ID: 18845535	2008
Recent inventions on receptor tyrosine kinase RET modulation. Recent patents on biotechnology\| PubMed ID: 19075852	2008
The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. Protein engineering, design & selection : PEDS\| PubMed ID: 19258449	2009
The immunoglobulin-binding Eib proteins from Escherichia coli are receptors for IgG Fc. Molecular immunology\| PubMed ID: 19303642	2009
Comparison of GFL-GFRalpha complexes: further evidence relating GFL bend angle to RET signalling. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 19478429	2009
Electrostatic interactions of Hsp-organizing protein tetratricopeptide domains with Hsp70 and Hsp90: computational analysis and protein engineering. The Journal of biological chemistry\| PubMed ID: 19586912	2009
Structural determinants of growth factor binding and specificity by VEGF receptor 2. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20145116	2010
Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d. Molecular immunology\| PubMed ID: 20378178	2010
First analysis of a bacterial collagen-binding protein with collagen Toolkits: promiscuous binding of YadA to collagens may explain how YadA interferes with host processes. Infection and immunity\| PubMed ID: 20439473	2010
A combined quantum chemical and crystallographic study on the oxidized binuclear center of cytochrome c oxidase. Biochimica et biophysica acta\| PubMed ID: 21211513	2011
Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21285368	2011
Cloning, expression, purification, crystallization and preliminary X-ray diffraction data of the Pyrococcus horikoshii RadA intein. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 21543876	2011
The structure of E. coli IgG-binding protein D suggests a general model for bending and binding in trimeric autotransporter adhesins. Structure (London, England : 1993)\| PubMed ID: 21742268	2011
Obesity risk gene TMEM18 encodes a sequence-specific DNA-binding protein. PloS one\| PubMed ID: 21980424	2011
Crystal structure and role of glycans and dimerization in folding of neuronal leucine-rich repeat protein AMIGO-1. Journal of molecular biology\| PubMed ID: 21983541	2011
The translocation domain in trimeric autotransporter adhesins is necessary and sufficient for trimerization and autotransportation. Journal of bacteriology\| PubMed ID: 22155776	2012
Human UDP-glucuronosyltransferase expression in insect cells: ratio of active to inactive recombinant proteins and the effects of a C-terminal his-tag on glucuronidation kinetics. Drug metabolism and disposition: the biological fate of chemicals\| PubMed ID: 22782802	2012
The structure and catalytic cycle of a sodium-pumping pyrophosphatase. Science (New York, N.Y.)\| PubMed ID: 22837527	2012
Crystallization and preliminary X-ray analysis of membrane-bound pyrophosphatases. Molecular membrane biology\| PubMed ID: 22881431	2013
Yersinia infection tools-characterization of structure and function of adhesins. Frontiers in cellular and infection microbiology\| PubMed ID: 23316485	2012
Structural basis for complement evasion by Lyme disease pathogen Borrelia burgdorferi. The Journal of biological chemistry\| PubMed ID: 23658013	2013
Inorganic pyrophosphatases: one substrate, three mechanisms. FEBS letters\| PubMed ID: 23684653	2013
The structure of the NTPase that powers DNA packaging into Sulfolobus turreted icosahedral virus 2. Journal of virology\| PubMed ID: 23698307	2013
Is the bovine lysosomal phospholipase B-like protein an amidase? Proteins\| PubMed ID: 23934913	2014
Proton/sodium pumping pyrophosphatases: the last of the primary ion pumps. Current opinion in structural biology\| PubMed ID: 24768824	2014
The major autoantibody epitope on factor H in atypical hemolytic uremic syndrome is structurally different from its homologous site in factor H-related protein 1, supporting a novel model fo... The Journal of biological chemistry\| PubMed ID: 25659429	2015
Solution structure and biophysical characterization of the multifaceted signalling effector protein growth arrest specific-1. BMC biochemistry\| PubMed ID: 25888394	2015
A Versatile Strategy for Production of Membrane Proteins with Diverse Topologies: Application to Investigation of Bacterial Homologues of Human Divalent Metal Ion and Nucleoside Transporters... PloS one\| PubMed ID: 26606682	2015
A method for detergent-free isolation of membrane proteins in their local lipid environment. Nature protocols\| PubMed ID: 27254461	2016
Artificial membranes for membrane protein purification, functionality and structure studies. Biochemical Society transactions\| PubMed ID: 27284055	2016
Transport mechanism of a glutamate transporter homologue GltPh. Biochemical Society transactions\| PubMed ID: 27284058	2016
Membrane pyrophosphatases from Thermotoga maritima and Vigna radiata suggest a conserved coupling mechanism. Nature communications\| PubMed ID: 27922000	2016
The crystal structure of PD1, a Haemophilus surface fibril domain. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 28177321	2017
Insights into the mechanism of membrane pyrophosphatases by combining experiment and computer simulation. Structural dynamics (Melville, N.Y.)\| PubMed ID: 28345008	2017
Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro. PloS one\| PubMed ID: 28467503	2017
Obesity: Receptors identified for a weight regulator. Nature\| PubMed ID: 28953879	2017
Using a SMALP platform to determine a sub-nm single particle cryo-EM membrane protein structure. Biochimica et biophysica acta\| PubMed ID: 28993151	2018
Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi. PloS one\| PubMed ID: 29190743	2017
Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 29247053	2018
Pacing across the membrane: the novel PACE family of efflux pumps is widespread in Gram-negative pathogens. Research in microbiology\| PubMed ID: 29409983	2018
Binding of EphrinA5 to RET receptor tyrosine kinase: An in vitro study. PloS one\| PubMed ID: 29889908	2018
A Simple Strategy to Determine the Dependence of Membrane-Bound Pyrophosphatases on K as a Cofactor. Methods in enzymology\| PubMed ID: 30149856	2018
Defining Dynamics of Membrane-Bound Pyrophosphatases by Experimental and Computational Single-Molecule FRET. Methods in enzymology\| PubMed ID: 30149870	2018
Substrate polyspecificity and conformational relevance in ABC transporters: new insights from structural studies. Biochemical Society transactions\| PubMed ID: 30514765	2018
Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation. Journal of molecular biology\| PubMed ID: 30878480	2019
Asymmetry in catalysis by membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor. Science advances\| PubMed ID: 31131322	2019
Glutamate transporters: a broad review of the most recent archaeal and human structures. Biochemical Society transactions\| PubMed ID: 31383819	2019
Structure of the UspA1 protein fragment from Moraxella catarrhalis responsible for C3d binding. Journal of structural biology\| PubMed ID: 31400508	2019
Improving on nature's shortcomings: evolving a lipase for increased lipolytic activity, expression and thermostability. Protein engineering, design & selection : PEDS\| PubMed ID: 31403166	2019
Evolving a lipase for hydrolysis of natural triglycerides along with enhanced tolerance towards a protease and surfactants. Protein engineering, design & selection : PEDS\| PubMed ID: 31504920	2019