Kazuhiro Kakimi

Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: implications for immunotherapy of persistent viral infections.

Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice.

Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes.

Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice.

Immune-based novel therapies for chronic hepatitis C virus infection.

[Recent advance in the study of immunopathobiology of hepatitis B virus infection using HBV transgenic mice].

Assessment of occult pancreatobiliary reflux in patients with pancreaticobiliary disease by ERCP.

Differential dynamics of the peripheral and intrahepatic cytotoxic T lymphocyte response to hepatitis B surface antigen.

Depletion of CD25+CD4+T cells (Tregs) enhances the HBV-specific CD8+ T cell response primed by DNA immunization.

The simultaneous blockade of chemokine receptors CCR2, CCR5 and CXCR3 by a non-peptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis.

Blockade of neutrophil elastase attenuates severe liver injury in hepatitis B transgenic mice.

Impairment of IFN-alpha production capacity in patients with hepatitis C virus and the risk of the development of hepatocellular carcinoma.

Cryopreservation does not alter the allogenicity and development of vasculopathy in post-transplant rat aortas.

Clinical utility of 2',5'-oligoadenylate synthetase activity measurement: using whole blood as a highly sensitive method to detect the effects of IFN.

Efficient priming and expansion of antigen-specific CD8+ T cells by a novel cell-based artificial APC.

Fulminant liver failure triggered by therapeutic antibody treatment in a mouse model.

Maintenance of memory CD8+ T cell diversity and proliferative potential by a primary response upon re-challenge.

Impaired IFN-alpha production and the risk of cancer development.

Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice.

Critical role of CD44 in hepatotoxin-mediated liver injury.

Dendritic cell vaccine with mRNA targeted to the proteasome by polyubiquitination.

Memory Th1 cells augment tumor-specific CTL following transcutaneous peptide immunization.

Pathological role of CD44 on NKT cells in carbon tetrachloride-mediated liver injury.

Active specific immunotherapy and cell-transfer therapy for the treatment of non-small cell lung cancer.

Anti-infectious activity of tryptophan metabolites in the L-tryptophan-L-kynurenine pathway.

Role of CD44 in CTL-induced acute liver injury in hepatitis B virus transgenic mice.

Impact of culture medium on the expansion of T cells for immunotherapy.

Efficient cross-presentation of soluble exogenous antigens introduced into dendritic cells using a weak-based amphiphilic peptide.

A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous gammadelta T cells.

UV irradiation of immunized mice induces type 1 regulatory T cells that suppress tumor antigen specific cytotoxic T lymphocyte responses.

Adoptive immunotherapy for advanced non-small cell lung cancer using zoledronate-expanded γδTcells: a phase I clinical study.

A phase I study of vaccination with NY-ESO-1f peptide mixed with Picibanil OK-432 and Montanide ISA-51 in patients with cancers expressing the NY-ESO-1 antigen.

γδ T-cell immunotherapy for lung cancer.

Exploring immune therapy for renal cancer.

UV irradiation of immunized mice induces type 1 regulatory T cells that suppress tumor antigen specific cytotoxic T lymphocyte responses.

Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration.

B cells regulate antibody responses through the medullary remodeling of inflamed lymph nodes.