nanoparticle-tracking-analysis-for-quantification-size-determination

Nanoparticle Tracking Analysis for the Quantification and Size Determination of Extracellular Vesicles

The physiological and pathophysiological roles of extracellular vesicles (EVs) have become increasingly recognized, making the EV field a quickly evolving ...

Columbia University Mailman School of Public Health

In utero particulate matter exposure produces oxidative stress that impacts cellular processes that include telomere biology. Newborn telomere length is likely critical to an individual's telomere biology; reduction in this initial telomere setting may signal increased susceptibility to adverse outcomes later in life. We examined associations between prenatal particulate matter with diameter ≤2.5 µm (PM) and relative leukocyte telomere length (LTL) measured in cord blood using a data-driven approach to characterize sensitive windows of prenatal PM effects and explore sex differences.

Association between prenatal particulate air pollution exposure and telomere length in cord blood: Effect modification by fetal sex.

 To quantify associations of anxiety and depression during pregnancy with differential cord blood DNA methylation of the glucorticoid receptor ().  Pregnancy anxiety, trait anxiety and depressive symptoms were collected using the Pregnancy Related Anxiety Scale, State-Trait Anxiety Index and Edinburgh Postnatal Depression Scale, respectively.  methylation was determined at four methylation sites.  DNA methylation of CpG 1 in the  CpG island shore was higher in infants born to women with high pregnancy anxiety (β 2.54, 95% CI: 0.49-4.58) and trait anxiety (β 1.68, 95% CI: 0.14-3.22). No significant association was found between depressive symptoms and  methylation.  We found that maternal anxiety was associated with increased  CpG island shore methylation.

Article	Year
Association between prenatal particulate air pollution exposure and telomere length in cord blood: Effect modification by fetal sex. Environmental research\| PubMed ID: 30852452	2019
Maternal anxiety and depression in pregnancy and DNA methylation of the glucocorticoid receptor gene. Epigenomics\| PubMed ID: 33215541	2020

Tessa R. Bloomquist

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