School of Applied and Engineering Physics
Chris Xu is the IBM Chair Professor of Engineering and director of the School of Applied and Engineering Physics, Cornell University. He is the Mong Family Foundation Director of Cornell Neurotech – Engineering. His current research areas are fiber optics and biomedical imaging, with major thrusts in multiphoton microscopy for deep brain imaging, multiphoton microendoscopy for clinical applications, and fiber-based devices and systems for telecommunications and optical imaging. Dr. Xu pioneered the development of temporal focusing and long wavelength two- and three-photon microscopy for deep tissue imaging. Prior to Cornell, he was a member of technical staff at Bell Laboratories, and pioneered breakthrough development of fiber optic communication systems based on differential phase-shift keying. He received his Ph.D. in Applied Physics, Cornell University, and his B.S. in Physics from Fudan University.
Dr. Xu has chaired or served on many conference organization committees and NSF/NIH review panels. He served on the NIH NEI External Scientific Oversight Committee of the Audacious Goal Initiative and is currently serving on the OSA Biomedical Congress Strategic Planning Committee. He served as Associate Editor for Biomedical Optics Express, and is on the editorial boards of several journals. He holds 25 patents on optical communications and imaging. He has won the NSF CAREER award, Bell Labs team research award, and the Tau Beta Pi and two other teaching awards from Cornell Engineering College. He received Cornell Engineering Research Excellence Award in 2017. He is a fellow of the National Academy of Inventors and a fellow of the Optical Society of America.
Photonic analog-to-digital converter using soliton self-frequency shift and interleaving spectral filters.
Optics letters Jun, 2003 | Pubmed ID: 12836754
Multiwavelength pulse generator using time-lens compression.
Optics letters Jul, 2004 | Pubmed ID: 15259716
Ultrafast optical delay line by use of a time-prism pair.
Optics letters Jan, 2005 | Pubmed ID: 15648651
Compensation of self-phase modulation in fiber-based chirped-pulse amplification systems.
Optics letters Jun, 2006 | Pubmed ID: 16688285
Demonstration of soliton self-frequency shift below 1300 nm in higher-order mode, solid silica-based fiber.
Optics letters Feb, 2007 | Pubmed ID: 17356646
Generation of femtosecond pulses at 1350 nm by Cerenkov radiation in higher-order-mode fiber.
Optics letters May, 2007 | Pubmed ID: 17410232
Generation of 3.5 nJ femtosecond pulses from a continuous-wave laser without mode locking.
Optics letters Jun, 2007 | Pubmed ID: 17546137
Large tunable delays using parametric mixing and phase conjugation in Si nanowaveguides.
Optics express Jul, 2008 | Pubmed ID: 18607445
Experimental and theoretical analysis of core-to-core coupling on fiber bundle imaging.
Optics express Dec, 2008 | Pubmed ID: 19104591
Generation of high repetition rate femtosecond pulses from a CW laser by a time-lens loop.
Optics express Apr, 2009 | Pubmed ID: 19365484
Tunable dispersion compensation by a rotating cylindrical lens.
Optics letters Apr, 2009 | Pubmed ID: 19370115
1 micros tunable delay using parametric mixing and optical phase conjugation in Si waveguides.
Optics express Apr, 2009 | Pubmed ID: 19399074
Enhanced axial confinement of sum-frequency generation in a temporal focusing setup.
Optics letters Jun, 2009 | Pubmed ID: 19529703
Deep tissue multiphoton microscopy using longer wavelength excitation.
Optics express Aug, 2009 | Pubmed ID: 19654740
Ultralong continuously tunable parametric delays via a cascading discrete stage.
Optics express Jan, 2010 | Pubmed ID: 20173853
Endoscope lens with dual fields of view and resolutions for multiphoton imaging.
Optics letters Aug, 2010 | Pubmed ID: 20717440
Synchronized time-lens source for coherent Raman scattering microscopy.
Optics express Nov, 2010 | Pubmed ID: 21164749
High speed multiphoton axial scanning through an optical fiber in a remotely scanned temporal focusing setup.
Biomedical optics express Dec, 2010 | Pubmed ID: 21326638
Wavelength-tunable high-energy soliton pulse generation from a large-mode-area fiber pumped by a time-lens source.
Optics letters Mar, 2011 | Pubmed ID: 21403736
Multiphoton microscopy for structure identification in human prostate and periprostatic tissue: implications in prostate cancer surgery.
BJU international Nov, 2011 | Pubmed ID: 21443651
Generation of Cerenkov radiation at 850 nm in higher-order-mode fiber.
Optics express Apr, 2011 | Pubmed ID: 21643129
High sensitivity third-order autocorrelation measurement by intensity modulation and third harmonic detection.
Optics letters Jun, 2011 | Pubmed ID: 21686024
Compact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissue.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2011 | Pubmed ID: 22006303
In vivo two-photon microscopy to 1.6-mm depth in mouse cortex.
Journal of biomedical optics Oct, 2011 | Pubmed ID: 22029361
Fiber-delivered picosecond source for coherent Raman scattering imaging.
Optics letters Nov, 2011 | Pubmed ID: 22048375
Time-domain multimode dispersion measurement in a higher-order-mode fiber.
Optics letters Feb, 2012 | Pubmed ID: 22297348
Use of a lensed fiber for a large-field-of-view, high-resolution, fiber-scanning microendoscope.
Optics letters Mar, 2012 | Pubmed ID: 22378425
Fiber delivered two-color picosecond source through nonlinear spectral transformation for coherent Raman scattering imaging.
Applied physics letters Feb, 2012 | Pubmed ID: 22393265
Multifocal multiphoton endoscope.
Optics letters Apr, 2012 | Pubmed ID: 22513682
In vivo imaging of unstained tissues using a compact and flexible multiphoton microendoscope.
Journal of biomedical optics Apr, 2012 | Pubmed ID: 22559671
In vivo imaging of unstained tissues using long gradient index lens multiphoton endoscopic systems.
Biomedical optics express May, 2012 | Pubmed ID: 22567597
Multiphoton tomographic imaging: a potential optical biopsy tool for detecting gastrointestinal inflammation and neoplasia.
Cancer prevention research (Philadelphia, Pa.) Nov, 2012 | Pubmed ID: 22961775
Three-color femtosecond source for simultaneous excitation of three fluorescent proteins in two-photon fluorescence microscopy.
Biomedical optics express Sep, 2012 | Pubmed ID: 23024893
Soliton Self-Frequency Shift: Experimental Demonstrations and Applications.
IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society , 2008 | Pubmed ID: 23055656
Intermodal Čerenkov radiation in a higher-order-mode fiber.
Optics letters Nov, 2012 | Pubmed ID: 23114312
Intermodal four-wave mixing in a higher-order-mode fiber.
Applied physics letters Oct, 2012 | Pubmed ID: 23152639
Frequency Multiplexed Multiphoton Phosphorescence Lifetime Microscopy.
Nature photonics Jan, 2013 | Pubmed ID: 23472061
Nanotools for neuroscience and brain activity mapping.
ACS nano Mar, 2013 | Pubmed ID: 23514423
Three-photon excited fluorescence imaging of unstained tissue using a GRIN lens endoscope.
Biomedical optics express May, 2013 | Pubmed ID: 23667782
Time-lens based hyperspectral stimulated Raman scattering imaging and quantitative spectral analysis.
Journal of biophotonics Oct, 2013 | Pubmed ID: 23840041
Multiphoton microscopy to identify and characterize the transition zone in a mouse model of Hirschsprung disease.
Journal of pediatric surgery Jun, 2013 | Pubmed ID: 23845620
Dual modality endomicroscope with optical zoom capability.
Biomedical optics express , 2013 | Pubmed ID: 24049671
Two-photon fluorescence imaging of intracellular hydrogen peroxide with chemoselective fluorescent probes.
Journal of biomedical optics Oct, 2013 | Pubmed ID: 24084856
In vivo three-photon microscopy of subcortical structures within an intact mouse brain.
Nature photonics Mar, 2013 | Pubmed ID: 24353743
Wavefront sensorless adaptive optics temporal focusing-based multiphoton microscopy.
Biomedical optics express Jun, 2014 | Pubmed ID: 24940539
Nonlinear structured-illumination enhanced temporal focusing multiphoton excitation microscopy with a digital micromirror device.
Biomedical optics express Aug, 2014 | Pubmed ID: 25136483
Measurements of multiphoton action cross sections for multiphoton microscopy.
Biomedical optics express Oct, 2014 | Pubmed ID: 25360361
Multiphoton gradient index endoscopy for evaluation of diseased human prostatic tissue ex vivo.
Journal of biomedical optics Nov, 2014 | Pubmed ID: 25415446
Femtosecond laser bone ablation with a high repetition rate fiber laser source.
Biomedical optics express Jan, 2015 | Pubmed ID: 25657872
Dispersion compensation in three-photon fluorescence microscopy at 1,700 nm.
Biomedical optics express Apr, 2015 | Pubmed ID: 25909022
Adaptive optics in multiphoton microscopy: comparison of two, three and four photon fluorescence.
Optics express Nov, 2015 | Pubmed ID: 26698772
Erythrocytes Are Oxygen-Sensing Regulators of the Cerebral Microcirculation.
Neuron Aug, 2016 | Pubmed ID: 27499087
Direct visualization of functional heterogeneity in hepatobiliary metabolism using 6-CFDA as model compound.
Biomedical optics express Sep, 2016 | Pubmed ID: 27699121
Nonresonant background suppression for coherent anti-Stokes Raman scattering microscopy using a multi-wavelength time-lens source.
Optics express Nov, 2016 | Pubmed ID: 27857399
Characterization and adaptive compression of a multi-soliton laser source.
Optics express Jan, 2017 | Pubmed ID: 28085826
In vivo three-photon imaging of activity of GCaMP6-labeled neurons deep in intact mouse brain.
Nature methods Apr, 2017 | Pubmed ID: 28218900
Two-photon Shack-Hartmann wavefront sensor.
Optics letters Mar, 2017 | Pubmed ID: 28295068
Correcting the limited view in optical-resolution photoacoustic microscopy.
Journal of biophotonics 02, 2018 | Pubmed ID: 28971578
Multiple Regions of Interest on Multiparametric Magnetic Resonance Imaging are Not Associated with Increased Detection of Clinically Significant Prostate Cancer on Fusion Biopsy.
The Journal of urology 09, 2018 | Pubmed ID: 29518433
Rapid volumetric imaging with Bessel-Beam three-photon microscopy.
Biomedical optics express Apr, 2018 | Pubmed ID: 29675334
Fiber-based tunable repetition rate source for deep tissue two-photon fluorescence microscopy.
Biomedical optics express May, 2018 | Pubmed ID: 29760989
Multiphoton imaging provides a superior optical biopsy to that of confocal laser endomicroscopy imaging for colorectal lesions.
Endoscopy 02, 2019 | Pubmed ID: 29996151
Investigation of the long wavelength limit of soliton self-frequency shift in a silica fiber.
Optics express Jul, 2018 | Pubmed ID: 30114134
Three-photon imaging of mouse brain structure and function through the intact skull.
Nature methods 10, 2018 | Pubmed ID: 30202059
Dynamic visualization of the recovery of mouse hepatobiliary metabolism to acetaminophen-overdose damage.
Journal of biophotonics 03, 2019 | Pubmed ID: 30302934
Comparing the effective attenuation lengths for long wavelength imaging of the mouse brain.
Biomedical optics express Aug, 2018 | Pubmed ID: 30338138
Real-time in vivo optical biopsy using confocal laser endomicroscopy to evaluate distal margin in situ and determine surgical procedure in low rectal cancer.
Surgical endoscopy 07, 2019 | Pubmed ID: 30386986
Multi-color background-free coherent anti-Stokes Raman scattering microscopy using a time-lens source.
Optics express Dec, 2018 | Pubmed ID: 30650870
Impact of the emission wavelengths on multiphoton imaging of mouse brains.
Biomedical optics express Apr, 2019 | Pubmed ID: 31061766
label-free confocal imaging of the deep mouse brain with long-wavelength illumination.
Biomedical optics express Dec, 2018 | Pubmed ID: 31065448
The Role of Systematic and Targeted Biopsies in Light of Overlap on Magnetic Resonance Imaging Ultrasound Fusion Biopsy.
European urology oncology 09, 2018 | Pubmed ID: 31100246
Corrigendum to 'The Role of Systematic and Targeted Biopsies in Light of Overlap on Magnetic Resonance Imaging Ultrasound Fusion Biopsy' [European Urology Oncology 1 (2018) 263-267].
European urology oncology Jun, 2020 | Pubmed ID: 31378664
An adaptive excitation source for high-speed multiphoton microscopy.
Nature methods 02, 2020 | Pubmed ID: 31792434
Quantitative analysis of 1300-nm three-photon calcium imaging in the mouse brain.
eLife 01, 2020 | Pubmed ID: 31999253
GHz Ultrasonic Chip-Scale Device Induces Ion Channel Stimulation in Human Neural Cells.
Scientific reports 02, 2020 | Pubmed ID: 32080204
Microscopic sensors using optical wireless integrated circuits.
Proceedings of the National Academy of Sciences of the United States of America 04, 2020 | Pubmed ID: 32303653
Deep three-photon imaging of the brain in intact adult zebrafish.
Nature methods 06, 2020 | Pubmed ID: 32341543
Fabrication of Injectable Micro-Scale Opto-Electronically Transduced Electrodes (MOTEs) for Physiological Monitoring.
Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems Oct, 2020 | Pubmed ID: 33071528
Memorial Viewpoint for Watt W. Webb: An Experimentalist's Experimentalist.
The journal of physical chemistry. B 03, 2021 | Pubmed ID: 33622036
Multicolor three-photon fluorescence imaging with single-wavelength excitation deep in mouse brain.
Science advances Mar, 2021 | Pubmed ID: 33731355
Closed-loop wavefront sensing and correction in the mouse brain with computed optical coherence microscopy.
Biomedical optics express Aug, 2021 | Pubmed ID: 34513234
Shot noise limits on binary detection in multiphoton imaging.
Biomedical optics express Nov, 2021 | Pubmed ID: 34858697
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