Robert J. Vassar
Department of Neurology
Northwestern University Feinberg School of Medicine
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The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2009 | Pubmed ID: 19828790
BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization.
Molecular neurodegeneration Aug, 2010 | Pubmed ID: 20731874
The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease.
Alzheimer's research & therapy May, 2011 | Pubmed ID: 21639952
Elevated Aβ42 in aged, non-demented individuals with cerebral atherosclerosis.
Current Alzheimer research Oct, 2013 | Pubmed ID: 23919773
ADAM10 prodomain mutations cause late-onset Alzheimer's disease: not just the latest FAD.
Neuron Oct, 2013 | Pubmed ID: 24139026
Targeting the β secretase BACE1 for Alzheimer's disease therapy.
The Lancet. Neurology Mar, 2014 | Pubmed ID: 24556009
Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease.
Molecular neurodegeneration May, 2014 | Pubmed ID: 24885175
The normal and pathologic roles of the Alzheimer's β-secretase, BACE1.
Current Alzheimer research , 2014 | Pubmed ID: 24893886
Molecular neurodegeneration: basic biology and disease pathways.
Molecular neurodegeneration Sep, 2014 | Pubmed ID: 25248568
Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level.
Molecular neurodegeneration Jan, 2015 | Pubmed ID: 25567526
Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease.
Acta neuropathologica 08, 2016 | Pubmed ID: 26993139
Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.
Neuroscience and biobehavioral reviews Jun, 2016 | Pubmed ID: 27044452
Seeds of Destruction: New Mechanistic Insights into the Role of Apolipoprotein E4 in Alzheimer's Disease.
Neuron 12, 2017 | Pubmed ID: 29216455
Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice.
Science translational medicine 09, 2018 | Pubmed ID: 30232227
ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease.
The Journal of biological chemistry 11, 2018 | Pubmed ID: 30315100
A promising, novel, and unique BACE1 inhibitor emerges in the quest to prevent Alzheimer's disease.
EMBO molecular medicine 11, 2018 | Pubmed ID: 30322841
Editorial: Implications for BACE1 Inhibitor Clinical Trials: Adult Conditional BACE1 Knockout Mice Exhibit Axonal Organization Defects in the Hippocampus.
The journal of prevention of Alzheimer's disease , 2019 | Pubmed ID: 30756113
Death by microglia.
The Journal of experimental medicine 11, 2019 | Pubmed ID: 31645368
Aβ-accelerated neurodegeneration caused by Alzheimer's-associated variant R1279Q is rescued by angiotensin system inhibition in mice.
Science translational medicine 09, 2020 | Pubmed ID: 32998969
Early detection and personalized medicine: Future strategies against Alzheimer's disease.
Progress in molecular biology and translational science , 2021 | Pubmed ID: 33453940
A promising new γ-secretase modulator for Alzheimer's disease.
The Journal of experimental medicine 04, 2021 | Pubmed ID: 33683299
The case for low-level BACE1 inhibition for the prevention of Alzheimer disease.
Nature reviews. Neurology 11, 2021 | Pubmed ID: 34548654
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