delivery-cardioactive-therapeutics-porcine-myocardial-infarction

Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model

Myocardial infarction is one of the leading causes of death and disability worldwide, and there is an urgent need for novel cardioprotective or ...

Westmead hospital

To define the temporal characteristics of atrial lesion growth (lesion surface area), local electrogram amplitude attenuation, and circuit impedance decrement during in vivo radiofrequency (RF) ablation with direct endocardial visualization (DEV).

Observations on Attenuation of Local Electrogram Amplitude and Circuit Impedance During Atrial Radiofrequency Ablation: An In vivo Investigation Using a Novel Direct Endocardial Visualization Catheter.

Cardiovascular disease prevention, including lifestyle modification, is important but underutilized. Mobile health strategies could address this gap but lack evidence of therapeutic benefit.

Effect of Lifestyle-Focused Text Messaging on Risk Factor Modification in Patients With Coronary Heart Disease: A Randomized Clinical Trial.

Longer procedural time is associated with complications in radiofrequency atrial fibrillation ablation. We sought to reduce ablation time and thereby potentially reduce complications. The aim was to compare the dimensions and complications of 40 W/30 s setting to that of high-power ablations (50-80 W) for 5 s in the in vitro and in vivo models.

Five seconds of 50-60 W radio frequency atrial ablations were transmural and safe: an in vitro mechanistic assessment and force-controlled in vivo validation.

Mobile health (mHealth) has huge potential to deliver preventative health services. However, there is paucity of literature on theoretical constructs, technical, practical, and regulatory considerations that enable delivery of such services.

Design Considerations in Development of a Mobile Health Intervention Program: The TEXT ME and TEXTMEDS Experience.

Gestational diabetes (GDM) is a highly prevalent disorder of pregnancy which portends a high risk for future type 2 diabetes. Limited evidence indicates lifestyle intervention prevents the development of diabetes, but most previously studied interventions are resource-intensive. Intervention programs that utilise newer technologies may be scalable at lower cost. This 6-month pilot randomized controlled trial tested the delivery of text messages linked to an activity monitor, adaptive physical activity goal setting, and limited face-to-face counseling, as an intervention to improve rates of post-partum glucose tolerance testing and lifestyle behaviours amongst women following a GDM pregnancy. Sixty subjects were randomised 2:1 intervention vs. control. Compared to control subjects, there were trends for intervention subjects to improve diet, increase physical activity, and lose weight. There was no difference between the groups in the rate of glucose tolerance testing. Only 46 (77%) subjects completed some, and 19 subjects completed all the elements of the final evaluation. Feedback regarding the text messages and activity monitor was highly positive. Overall, results suggest that a text message and activity monitor intervention is feasible for a larger study or even as a potentially scalable population health intervention. However, low completion rates necessitate carefully considered modification of the protocol.

A Pilot Randomised Controlled Trial of a Text Messaging Intervention with Customisation Using Linked Data from Wireless Wearable Activity Monitors to Improve Risk Factors Following Gestational Diabetes.

Arrhythmias are common cardiac diseases which can be treated effectively by the cardiac radiofrequency ablation (CRFA). However, information regarding the lesion growth within the myocardium is critical to the procedure's safety and efficacy but still unavailable in the current catheterisation lab (CathLab). Over the last 20 years, many efforts have been made in order to track the lesion size during the procedure. Unfortunately, all the approaches have their own limitations preventing them from the clinical translation and hence making the lesion size monitoring during a CRFA still an open issue. Electrical Impedance Tomography (EIT) is an impedance imaging modality that might be able to image the thermal-related impedance changes from which the lesion size can be measured. With the availability of the patient's CT scans, for a detailed model, and the catheter-based electrodes for the internal electrodes, EIT accuracy and sensitivity to the ablated sites can be significantly improved and is worth being explored for this application. Though EIT is still new to CRFA with no in-vivo experiments being done according to our up-to-date searching, many related EIT studies and its extensive research in Hyperthermia and other ablations can reveal many hints for a possibility of the CRFA-EIT application. In this paper, we present a review on multiple aspects of EIT in CRFA. First, the expected CRFA-EIT signal range and frequency are discussed based on various measured impedance results obtained from lesions in the past. Second, the possible noise sources that can happen in a clinical CRFA procedure, along with their signal range and frequency compared to the CRFA-EIT signal, and, third, the available current solutions to separate such noises from the CRFA-EIT signal. Finally, we review the progress of EIT in thermal applications over the last two decades in order to identify the developments that EIT can take advantage of and the current drawbacks that need to be solved for a potential CRFA-EIT application.

Electrical Impedance Tomography for monitoring cardiac radiofrequency ablation: a scoping review of an emerging technology.

To evaluate the immediate effect of text messages promoting healthy lifestyle and supporting parenting on physical activity amongst women with recent gestational diabetes (GDM).

Text messages promoting healthy lifestyle and linked with activity monitors stimulate an immediate increase in physical activity among women after gestational diabetes.

Tony Barry

Department of Cardiology

Westmead hospital

Delivery of Cardioactive Therapeutics in a Porcine Myocardial Infarction Model