Yale Cancer Center
Lieping Chen has not added Biography.
If you are Lieping Chen and would like to personalize this page please email our Author Liaison for assistance.
Interleukin 4 receptor-directed cytotoxin therapy for human head and neck squamous cell carcinoma in animal models.
Clinical cancer research : an official journal of the American Association for Cancer Research Jan, 2002 | Pubmed ID: 11801570
Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2002 | Pubmed ID: 11801689
Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease.
The Journal of clinical investigation Feb, 2002 | Pubmed ID: 11854328
Reassessment of CD62L as a marker of pre-effector T cells in the tumor draining lymph nodes of head and neck cancer patients.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Feb, 2002 | Pubmed ID: 11870350
Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors.
The Journal of clinical investigation Mar, 2002 | Pubmed ID: 11877473
Immunotherapy of human papillomavirus-associated malignancies and the challenges posed by T-cell tolerance.
Frontiers in bioscience : a journal and virtual library Apr, 2002 | Pubmed ID: 11897572
Strategies for antigen loading of dendritic cells to enhance the antitumor immune response.
Cancer research Mar, 2002 | Pubmed ID: 11912169
Antibody gene therapy: old wine in a new bottle.
Nature medicine Apr, 2002 | Pubmed ID: 11927934
Ligand binding sites of inducible costimulator and high avidity mutants with improved function.
The Journal of experimental medicine Apr, 2002 | Pubmed ID: 11956294
Cutting edge: Expression of functional CD137 receptor by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) May, 2002 | Pubmed ID: 11970964
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity.
Cancer research Feb, 2005 | Pubmed ID: 15705911
Cutting edge: selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT.
Journal of immunology (Baltimore, Md. : 1950) May, 2002 | Pubmed ID: 11994431
Modulation of dendritic cell differentiation and maturation by decoy receptor 3.
Journal of immunology (Baltimore, Md. : 1950) May, 2002 | Pubmed ID: 11994433
Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells.
Cancer research Jun, 2002 | Pubmed ID: 12067989
Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.
Nature medicine Aug, 2002 | Pubmed ID: 12091876
Immunoglobulin fusion proteins as a tool for evaluation of T-cell costimulatory molecules.
Molecular biotechnology Jul, 2002 | Pubmed ID: 12102550
Impaired infiltration of tumor-specific cytolytic T cells in the absence of interferon-gamma despite their normal maturation in lymphoid organs during CD137 monoclonal antibody therapy.
Cancer research Aug, 2002 | Pubmed ID: 12154048
Signaling through NK cell-associated CD137 promotes both helper function for CD8+ cytolytic T cells and responsiveness to IL-2 but not cytolytic activity.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2002 | Pubmed ID: 12370353
Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease.
Nature medicine Dec, 2002 | Pubmed ID: 12426559
Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells.
The Journal of experimental medicine Nov, 2002 | Pubmed ID: 12438431
B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression.
Blood Apr, 2003 | Pubmed ID: 12468426
[Antitumor immunity elicited by 4-1BBL gene transfected Hepa1-6 in vivo].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology Dec, 2002 | Pubmed ID: 12502438
Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis.
The Journal of clinical investigation Feb, 2003 | Pubmed ID: 12569162
Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2003 | Pubmed ID: 12574348
B7 family molecules are favorably positioned at the human maternal-fetal interface.
Biology of reproduction May, 2003 | Pubmed ID: 12606489
Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity.
Nature medicine May, 2003 | Pubmed ID: 12704383
Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells.
American journal of respiratory cell and molecular biology May, 2003 | Pubmed ID: 12707012
Characterization of antigen processing machinery and Survivin expression in tonsillar squamous cell carcinoma.
Cancer May, 2003 | Pubmed ID: 12712472
Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction.
The Journal of experimental medicine May, 2003 | Pubmed ID: 12719480
B7-H1 pathway and its role in the evasion of tumor immunity.
Journal of molecular medicine (Berlin, Germany) May, 2003 | Pubmed ID: 12721664
A simple and rapid vortex method for preparing antigen/adjuvant emulsions for immunization.
Journal of immunological methods May, 2003 | Pubmed ID: 12738377
B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.
Immunity Jun, 2003 | Pubmed ID: 12818165
Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor.
The Journal of experimental medicine Jul, 2003 | Pubmed ID: 12847135
Differential binding properties of B7-H1 and B7-DC to programmed death-1.
Biochemical and biophysical research communications Aug, 2003 | Pubmed ID: 12893276
Cancer therapeutic monoclonal antibodies targeting lymphocyte co-stimulatory pathways.
Current opinion in investigational drugs (London, England : 2000) Jun, 2003 | Pubmed ID: 12901227
Autoimmune diabetes in HLA-DR3/DQ8 transgenic mice expressing the co-stimulatory molecule B7-1 in the beta cells of islets of Langerhans.
International immunology Sep, 2003 | Pubmed ID: 12917255
Human muscle cells express a B7-related molecule, B7-H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Oct, 2003 | Pubmed ID: 12923066
Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo.
Blood Jan, 2004 | Pubmed ID: 12969968
Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2003 | Pubmed ID: 14530338
B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.
Cancer research Oct, 2003 | Pubmed ID: 14559843
Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2003 | Pubmed ID: 14568939
Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis.
Cancer research Nov, 2003 | Pubmed ID: 14612546
Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2003 | Pubmed ID: 14662900
New B7 family members with positive and negative costimulatory function.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons Jan, 2004 | Pubmed ID: 14678029
Immunology of B7-H1 and its roles in human diseases.
International journal of hematology Nov, 2003 | Pubmed ID: 14686489
Costimulation-based immunotherapy for head and neck cancer.
Current treatment options in oncology Feb, 2004 | Pubmed ID: 14697154
CD137 signaling interferes with activation and function of CD4+CD25+ regulatory T cells in induced tolerance to experimental autoimmune thyroiditis.
Cellular immunology Nov, 2003 | Pubmed ID: 14746804
Control of autoimmune diseases by the B7-CD28 family molecules.
Current pharmaceutical design , 2004 | Pubmed ID: 14754392
Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection.
The Journal of clinical investigation Mar, 2004 | Pubmed ID: 14991067
B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes.
Immunity Mar, 2004 | Pubmed ID: 15030776
Structural and functional analysis of the costimulatory receptor programmed death-1.
Immunity Mar, 2004 | Pubmed ID: 15030777
Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigens.
International journal of cancer. Journal international du cancer May, 2004 | Pubmed ID: 15054868
Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors.
Oncogene May, 2004 | Pubmed ID: 15077191
Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity.
Nature reviews. Immunology May, 2004 | Pubmed ID: 15122199
Selective suppression of dendritic cell functions by cigarette smoke extract.
Chest May, 2004 | Pubmed ID: 15136445
53BP1 is required for class switch recombination.
The Journal of cell biology May, 2004 | Pubmed ID: 15159415
Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses.
Microbes and infection / Institut Pasteur Jul, 2004 | Pubmed ID: 15207823
Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity.
Cancer research Jul, 2004 | Pubmed ID: 15256470
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.
Nature medicine Sep, 2004 | Pubmed ID: 15322536
Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis.
Journal of neuroimmunology Oct, 2004 | Pubmed ID: 15342209
B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2004 | Pubmed ID: 15494491
Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2004 | Pubmed ID: 15569934
Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2004 | Pubmed ID: 15585834
Anti-CD137 mAb treatment inhibits experimental autoimmune uveitis by limiting expansion and increasing apoptotic death of uveitogenic T cells.
Investigative ophthalmology & visual science Feb, 2005 | Pubmed ID: 15671287
B7-H3 promotes acute and chronic allograft rejection.
European journal of immunology Feb, 2005 | Pubmed ID: 15682454
Therapeutic efficacy of MUC1-specific cytotoxic T lymphocytes and CD137 co-stimulation in a spontaneous breast cancer model.
Breast disease , 2004 | Pubmed ID: 15687707
Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2005 | Pubmed ID: 15758163
Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus.
Vaccine May, 2005 | Pubmed ID: 15855007
In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses.
The Journal of experimental medicine May, 2005 | Pubmed ID: 15897272
Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells.
American journal of respiratory cell and molecular biology Sep, 2005 | Pubmed ID: 15961727
Role of B7-H1 and B7-H4 molecules in down-regulating effector phase of T-cell immunity: novel cancer escaping mechanisms.
Frontiers in bioscience : a journal and virtual library , 2005 | Pubmed ID: 15970540
Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2005 | Pubmed ID: 16081845
Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research Aug, 2005 | Pubmed ID: 16115907
Renewed interest in cancer immunotherapy with the tumor necrosis factor superfamily molecules.
Cancer immunology, immunotherapy : CII Apr, 2006 | Pubmed ID: 16187084
Costimulatory molecule B7-H1 in primary and metastatic clear cell renal cell carcinoma.
Cancer Nov, 2005 | Pubmed ID: 16208700
T lymphocyte co-signaling pathways of the B7-CD28 family.
Cellular & molecular immunology Feb, 2004 | Pubmed ID: 16212919
Renal tubular epithelial cells modulate T-cell responses via ICOS-L and B7-H1.
Kidney international Nov, 2005 | Pubmed ID: 16221208
The many sounds of T lymphocyte silence.
Immunologic research , 2005 | Pubmed ID: 16234580
B7-H1 (CD274) inhibits the development of herpetic stromal keratitis (HSK).
FEBS letters Nov, 2005 | Pubmed ID: 16253242
Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274).
FEBS letters Feb, 2006 | Pubmed ID: 16413538
Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma.
Cancer research Feb, 2006 | Pubmed ID: 16489051
Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis.
The Journal of clinical investigation Apr, 2006 | Pubmed ID: 16557300
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma.
The Journal of experimental medicine Apr, 2006 | Pubmed ID: 16606666
Reviving exhausted T lymphocytes during chronic virus infection by B7-H1 blockade.
Trends in molecular medicine Jun, 2006 | Pubmed ID: 16650803
Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2006 | Pubmed ID: 16785496
The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans.
Experimental hematology Jul, 2006 | Pubmed ID: 16797416
Does decentralisation improve human resource management in the health sector? A case study from China.
Social science & medicine (1982) Oct, 2006 | Pubmed ID: 16808993
Inhibition of Th2-mediated allergic airway inflammatory disease by CD137 costimulation.
Journal of immunology (Baltimore, Md. : 1950) Jul, 2006 | Pubmed ID: 16818735
Modulation of immune response by B7 family molecules in tumor microenvironments.
Immunological investigations , 2006 | Pubmed ID: 16916759
Suppression of human T-cell responses to beta-cells by activation of B7-H4 pathway.
Cell transplantation , 2006 | Pubmed ID: 16970282
Human bone marrow: a reservoir for "enhanced effector memory" CD8+ T cells with potent recall function.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2006 | Pubmed ID: 17082586
Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease.
Blood May, 2007 | Pubmed ID: 17179227
Filoviruses and the balance of innate, adaptive, and inflammatory responses.
Viral immunology , 2006 | Pubmed ID: 17201655
Effects of specific immunotherapy on the B7 family of costimulatory molecules in allergic inflammation.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2007 | Pubmed ID: 17237444
CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype.
Blood Jun, 2007 | Pubmed ID: 17244673
Immunostimulatory monoclonal antibodies for cancer therapy.
Nature reviews. Cancer Feb, 2007 | Pubmed ID: 17251916
Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy.
Blood Jul, 2007 | Pubmed ID: 17289811
Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2007 | Pubmed ID: 17371976
Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells.
Blood Jul, 2007 | Pubmed ID: 17392506
The new B7s: playing a pivotal role in tumor immunity.
Journal of immunotherapy (Hagerstown, Md. : 1997) Apr, 2007 | Pubmed ID: 17414316
B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B.
Journal of immunology (Baltimore, Md. : 1950) May, 2007 | Pubmed ID: 17475895
LIGHT-related molecular network in the regulation of innate and adaptive immunity.
Immunologic research , 2007 | Pubmed ID: 17496344
How Ebola and Marburg viruses battle the immune system.
Nature reviews. Immunology Jul, 2007 | Pubmed ID: 17589545
Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma.
Cancer research Sep, 2007 | Pubmed ID: 17875732
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2007 | Pubmed ID: 17968013
Blockade of endogenous B7-H1 suppresses antibacterial protection after primary Listeria monocytogenes infection.
Immunology Jan, 2008 | Pubmed ID: 17971153
Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance.
Hepatology (Baltimore, Md.) Jan, 2008 | Pubmed ID: 17975811
Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.
The Journal of clinical investigation Jan, 2008 | Pubmed ID: 18060045
Blocking of monocyte-associated B7-H1 (CD274) enhances HCV-specific T cell immunity in chronic hepatitis C infection.
Journal of leukocyte biology Mar, 2008 | Pubmed ID: 18086898
B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells.
Blood Apr, 2008 | Pubmed ID: 18223165
CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice.
Circulation Mar, 2008 | Pubmed ID: 18285570
B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis.
European journal of immunology Jun, 2008 | Pubmed ID: 18421793
Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2008 | Pubmed ID: 18490751
Inhibitory B7-family molecules in the tumour microenvironment.
Nature reviews. Immunology Jun, 2008 | Pubmed ID: 18500231
Fc-dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodies.
Blood Aug, 2008 | Pubmed ID: 18519814
Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta.
Cancer research Jul, 2008 | Pubmed ID: 18593946
B7-H1 on hepatocytes facilitates priming of specific CD8 T cells but limits the specific recall of primed responses.
Gastroenterology Sep, 2008 | Pubmed ID: 18621049
PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE.
European journal of immunology Oct, 2008 | Pubmed ID: 18825752
Cutting edge: IFN-gamma enables APC to promote memory Th17 and abate Th1 cell development.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2008 | Pubmed ID: 18941172
Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection.
Journal of neuroinflammation , 2008 | Pubmed ID: 18947414
B7-H4-deficient mice display augmented neutrophil-mediated innate immunity.
Blood Feb, 2009 | Pubmed ID: 19109567
Functional B7.2 and B7-H2 molecules on myeloma cells are associated with a growth advantage.
Clinical cancer research : an official journal of the American Association for Cancer Research Feb, 2009 | Pubmed ID: 19188146
B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2009 | Pubmed ID: 19202065
Turning the tide of lymphocyte costimulation.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2009 | Pubmed ID: 19234146
Palettes of vaccines and immunostimulatory monoclonal antibodies for combination.
Clinical cancer research : an official journal of the American Association for Cancer Research Mar, 2009 | Pubmed ID: 19240168
Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival.
Transplantation Feb, 2009 | Pubmed ID: 19307783
PD-1 on dendritic cells impedes innate immunity against bacterial infection.
Blood Jun, 2009 | Pubmed ID: 19339692
Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity.
Journal of immunology (Baltimore, Md. : 1950) May, 2009 | Pubmed ID: 19380790
Fine tuning the immune response through B7-H3 and B7-H4.
Immunological reviews May, 2009 | Pubmed ID: 19426220
B and T lymphocyte attenuator tempers early infection immunity.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2009 | Pubmed ID: 19587015
Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease.
Blood Oct, 2009 | Pubmed ID: 19602708
Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion.
Blood Oct, 2009 | Pubmed ID: 19641184
Tumor-expressed B7-H1 and B7-DC in relation to PD-1+ T-cell infiltration and survival of patients with cervical carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research Oct, 2009 | Pubmed ID: 19825956
Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions.
Cancer research Oct, 2009 | Pubmed ID: 19826049
Potential role of decoy B7-H4 in the pathogenesis of rheumatoid arthritis: a mouse model informed by clinical data.
PLoS medicine Oct, 2009 | Pubmed ID: 19841745
NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7-H1 up-regulation.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2009 | Pubmed ID: 19890047
Leucocyte-associated immunoglobulin-like receptor-1 is an inhibitory regulator of contact hypersensitivity.
Immunology Dec, 2009 | Pubmed ID: 19930044
Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2010 | Pubmed ID: 20065112
CD137 agonist antibody prevents cancer recurrence: contribution of CD137 on both hematopoietic and nonhematopoietic cells.
Blood Mar, 2010 | Pubmed ID: 20068221
Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ.
Cancer immunology, immunotherapy : CII Aug, 2010 | Pubmed ID: 20336294
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells.
Nature immunology Jun, 2010 | Pubmed ID: 20453843
B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance.
Blood Aug, 2010 | Pubmed ID: 20472828
Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.
Blood Aug, 2010 | Pubmed ID: 20472834
Retraction: Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2010 | Pubmed ID: 20483792
Deficiency in B7-H1 (PD-L1)/PD-1 coinhibition triggers pancreatic beta-cell destruction by insulin-specific, murine CD8 T-cells.
Diabetes Aug, 2010 | Pubmed ID: 20484136
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology Jul, 2010 | Pubmed ID: 20516446
Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.
Blood Sep, 2010 | Pubmed ID: 20574047
Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways.
Current topics in microbiology and immunology , 2011 | Pubmed ID: 20582531
Structural immunology of costimualtory and coinhibitory molecules.
Science China. Life sciences Feb, 2010 | Pubmed ID: 20596825
B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2010 | Pubmed ID: 20686128
Retraction: Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity.
Cancer research Nov, 2010 | Pubmed ID: 21045150
CD137-mediated pathogenesis from chronic hepatitis to hepatocellular carcinoma in hepatitis B virus-transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) Dec, 2010 | Pubmed ID: 21059892
B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis.
European journal of immunology Nov, 2010 | Pubmed ID: 21061440
CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies.
Blood Feb, 2011 | Pubmed ID: 21193697
Host APCs augment in vivo expansion of donor natural regulatory T cells via B7H1/B7.1 in allogeneic recipients.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2011 | Pubmed ID: 21263067
Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.
Journal of immunology (Baltimore, Md. : 1950) May, 2011 | Pubmed ID: 21441458
Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells.
Journal of immunology (Baltimore, Md. : 1950) May, 2011 | Pubmed ID: 21490158
Cell surface signaling molecules in the control of immune responses: a tide model.
Immunity Apr, 2011 | Pubmed ID: 21511182
B7-h2 is a costimulatory ligand for CD28 in human.
Immunity May, 2011 | Pubmed ID: 21530327
The development and functions of CD4(+) T cells expressing a transgenic TCR specific for an MHC-I-restricted tumor antigenic epitope.
Cellular & molecular immunology Jul, 2011 | Pubmed ID: 21643003
Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2011 | Pubmed ID: 21768399
Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation.
Cell stem cell Aug, 2011 | Pubmed ID: 21816363
Expression of anti-HVEM single-chain antibody on tumor cells induces tumor-specific immunity with long-term memory.
Cancer immunology, immunotherapy : CII Feb, 2012 | Pubmed ID: 21877247
B7-H4 induces donor-specific tolerance in mouse islet allografts.
Cell transplantation , 2012 | Pubmed ID: 21929869
Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes.
Diabetes Dec, 2011 | Pubmed ID: 21984581
B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies.
Journal of transplantation , 2011 | Pubmed ID: 22028949
Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice.
The Journal of clinical investigation Dec, 2011 | Pubmed ID: 22080867
Loss of B7-H1 expression by recipient parenchymal cells leads to expansion of infiltrating donor CD8+ T cells and persistence of graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2012 | Pubmed ID: 22156590
Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy.
The Yale journal of biology and medicine Dec, 2011 | Pubmed ID: 22180678
B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation.
PloS one , 2012 | Pubmed ID: 22238573
Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer.
The Journal of clinical investigation Feb, 2012 | Pubmed ID: 22326955
The B7 homologues and their receptors in hematologic malignancies.
European journal of haematology Jun, 2012 | Pubmed ID: 22372959
Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells.
Cancer research Jun, 2012 | Pubmed ID: 22427351
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape.
Science translational medicine Mar, 2012 | Pubmed ID: 22461641
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
The New England journal of medicine Jun, 2012 | Pubmed ID: 22658127
PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model.
PloS one , 2012 | Pubmed ID: 22761734
Blockade of both B7-H4 and CTLA-4 co-signaling pathways enhances mouse islet allograft survival.
Islets Jul, 2012 | Pubmed ID: 22878670
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.
Blood Dec, 2012 | Pubmed ID: 22993390
Durable Cancer Regression Off-treatment and Effective Re-induction Therapy with an Anti-PD-1 Antibody.
Clinical cancer research : an official journal of the American Association for Cancer Research Nov, 2012 | Pubmed ID: 23169436
Endogenous Expression of B7-H4 Improves Long-term Murine Islet Allograft Survival.
Transplantation Jan, 2013 | Pubmed ID: 23192157
Elaine Bigelow1,2,
Katherine M. Bever1,2,
Haiying Xu1,2,3,
Allison Yager1,
Annie Wu1,2,4,
Janis Taube3,5,
Lieping Chen6,
Elizabeth M. Jaffee1,2,5,7,8,
Robert A. Anders1,2,5,8,
Lei Zheng1,2,4,5,7
1The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine,
2Department of Oncology, The Johns Hopkins University School of Medicine,
3Department of Dermatology, The Johns Hopkins University School of Medicine,
4Department of Surgery, Johns Hopkins University School of Medicine,
5The Sol Goldman Pancreatic Cancer Center, The Johns Hopkins University School of Medicine,
6Yale Cancer Center, Yale School of Medicine,
7The Skip Viragh Center for Pancreatic Cancer, The Johns Hopkins University School of Medicine,
8Department of Pathology, The Johns Hopkins University School of Medicine
ABOUT JoVE
Copyright © 2024 MyJoVE Corporation. All rights reserved