Lieping Chen

Interleukin 4 receptor-directed cytotoxin therapy for human head and neck squamous cell carcinoma in animal models.

Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of experimental autoimmune encephalomyelitis.

Blockade of LIGHT/LTbeta and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease.

Reassessment of CD62L as a marker of pre-effector T cells in the tumor draining lymph nodes of head and neck cancer patients.

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors.

Immunotherapy of human papillomavirus-associated malignancies and the challenges posed by T-cell tolerance.

Strategies for antigen loading of dendritic cells to enhance the antitumor immune response.

Antibody gene therapy: old wine in a new bottle.

Ligand binding sites of inducible costimulator and high avidity mutants with improved function.

Cutting edge: Expression of functional CD137 receptor by dendritic cells.

Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity.

Cutting edge: selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT.

Modulation of dendritic cell differentiation and maturation by decoy receptor 3.

Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells.

Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion.

Immunoglobulin fusion proteins as a tool for evaluation of T-cell costimulatory molecules.

Impaired infiltration of tumor-specific cytolytic T cells in the absence of interferon-gamma despite their normal maturation in lymphoid organs during CD137 monoclonal antibody therapy.

Signaling through NK cell-associated CD137 promotes both helper function for CD8+ cytolytic T cells and responsiveness to IL-2 but not cytolytic activity.

Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease.

Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells.

B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression.

[Antitumor immunity elicited by 4-1BBL gene transfected Hepa1-6 in vivo].

Costimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis.

Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells.

B7 family molecules are favorably positioned at the human maternal-fetal interface.

Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity.

Expression of the costimulatory molecule B7-H2 (inducible costimulator ligand) by human airway epithelial cells.

Characterization of antigen processing machinery and Survivin expression in tonsillar squamous cell carcinoma.

Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction.

B7-H1 pathway and its role in the evasion of tumor immunity.

A simple and rapid vortex method for preparing antigen/adjuvant emulsions for immunization.

B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.

Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor.

Differential binding properties of B7-H1 and B7-DC to programmed death-1.

Cancer therapeutic monoclonal antibodies targeting lymphocyte co-stimulatory pathways.

Autoimmune diabetes in HLA-DR3/DQ8 transgenic mice expressing the co-stimulatory molecule B7-1 in the beta cells of islets of Langerhans.

Human muscle cells express a B7-related molecule, B7-H1, with strong negative immune regulatory potential: a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies.

Ligation of CD137 receptor prevents and reverses established anergy of CD8+ cytolytic T lymphocytes in vivo.

Blockade of B7-H1 suppresses the development of chronic intestinal inflammation.

B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.

Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family.

Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis.

Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism.

New B7 family members with positive and negative costimulatory function.

Immunology of B7-H1 and its roles in human diseases.

Costimulation-based immunotherapy for head and neck cancer.

CD137 signaling interferes with activation and function of CD4+CD25+ regulatory T cells in induced tolerance to experimental autoimmune thyroiditis.

Control of autoimmune diseases by the B7-CD28 family molecules.

Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection.

B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes.

Structural and functional analysis of the costimulatory receptor programmed death-1.

Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with anti-CD137 monoclonal antibodies and alloantigens.

Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors.

Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity.

Selective suppression of dendritic cell functions by cigarette smoke extract.

53BP1 is required for class switch recombination.

Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses.

Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity.

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.

Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis.

B7-H3 enhances tumor immunity in vivo by costimulating rapid clonal expansion of antigen-specific CD8+ cytolytic T cells.

Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target.

Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation.

Anti-CD137 mAb treatment inhibits experimental autoimmune uveitis by limiting expansion and increasing apoptotic death of uveitogenic T cells.

B7-H3 promotes acute and chronic allograft rejection.

Therapeutic efficacy of MUC1-specific cytotoxic T lymphocytes and CD137 co-stimulation in a spontaneous breast cancer model.

Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.

Enhancement of CD4 and CD8 immunity by anti-CD137 (4-1BB) monoclonal antibodies during hepatitis C vaccination with recombinant adenovirus.

In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses.

Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells.

Role of B7-H1 and B7-H4 molecules in down-regulating effector phase of T-cell immunity: novel cancer escaping mechanisms.

Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming.

Expression of functional B7-H2 and B7.2 costimulatory molecules and their prognostic implications in de novo acute myeloid leukemia.

Renewed interest in cancer immunotherapy with the tumor necrosis factor superfamily molecules.

Costimulatory molecule B7-H1 in primary and metastatic clear cell renal cell carcinoma.

T lymphocyte co-signaling pathways of the B7-CD28 family.

Renal tubular epithelial cells modulate T-cell responses via ICOS-L and B7-H1.

The many sounds of T lymphocyte silence.

B7-H1 (CD274) inhibits the development of herpetic stromal keratitis (HSK).

Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274).

Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma.

Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis.

B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma.

Reviving exhausted T lymphocytes during chronic virus infection by B7-H1 blockade.

Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells.

The role of leukemia-derived B7-H1 (PD-L1) in tumor-T-cell interactions in humans.

Does decentralisation improve human resource management in the health sector? A case study from China.

Inhibition of Th2-mediated allergic airway inflammatory disease by CD137 costimulation.

Modulation of immune response by B7 family molecules in tumor microenvironments.

Suppression of human T-cell responses to beta-cells by activation of B7-H4 pathway.

Human bone marrow: a reservoir for "enhanced effector memory" CD8+ T cells with potent recall function.

Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease.

Filoviruses and the balance of innate, adaptive, and inflammatory responses.

Effects of specific immunotherapy on the B7 family of costimulatory molecules in allergic inflammation.

CD137 stimulation delivers an antigen-independent growth signal for T lymphocytes with memory phenotype.

Immunostimulatory monoclonal antibodies for cancer therapy.

Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy.

Cytokine-mediated disruption of lymphocyte trafficking, hemopoiesis, and induction of lymphopenia, anemia, and thrombocytopenia in anti-CD137-treated mice.

Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells.

The new B7s: playing a pivotal role in tumor immunity.

B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B.

LIGHT-related molecular network in the regulation of innate and adaptive immunity.

How Ebola and Marburg viruses battle the immune system.

Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma.

Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability.

Blockade of endogenous B7-H1 suppresses antibacterial protection after primary Listeria monocytogenes infection.

Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance.

Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.

Blocking of monocyte-associated B7-H1 (CD274) enhances HCV-specific T cell immunity in chronic hepatitis C infection.

B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells.

CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice.

B7-H1 restricts neuroantigen-specific T cell responses and confines inflammatory CNS damage: implications for the lesion pathogenesis of multiple sclerosis.

Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis.

Inhibitory B7-family molecules in the tumour microenvironment.

Fc-dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodies.

Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta.

B7-H1 on hepatocytes facilitates priming of specific CD8 T cells but limits the specific recall of primed responses.

PD-1 ligands expressed on myeloid-derived APC in the CNS regulate T-cell responses in EAE.

Cutting edge: IFN-gamma enables APC to promote memory Th17 and abate Th1 cell development.

Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection.

B7-H4-deficient mice display augmented neutrophil-mediated innate immunity.

Functional B7.2 and B7-H2 molecules on myeloma cells are associated with a growth advantage.

B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation.

Turning the tide of lymphocyte costimulation.

Palettes of vaccines and immunostimulatory monoclonal antibodies for combination.

Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival.

PD-1 on dendritic cells impedes innate immunity against bacterial infection.

Target-dependent B7-H1 regulation contributes to clearance of central nervous system infection and dampens morbidity.

Fine tuning the immune response through B7-H3 and B7-H4.

B and T lymphocyte attenuator tempers early infection immunity.

Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease.

Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion.

Tumor-expressed B7-H1 and B7-DC in relation to PD-1+ T-cell infiltration and survival of patients with cervical carcinoma.

Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions.

Potential role of decoy B7-H4 in the pathogenesis of rheumatoid arthritis: a mouse model informed by clinical data.

NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T cell allostimulatory activity via B7-H1 up-regulation.

Leucocyte-associated immunoglobulin-like receptor-1 is an inhibitory regulator of contact hypersensitivity.

Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis.

CD137 agonist antibody prevents cancer recurrence: contribution of CD137 on both hematopoietic and nonhematopoietic cells.

Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ.

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells.

B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance.

Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.

Retraction: Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells.

Deficiency in B7-H1 (PD-L1)/PD-1 coinhibition triggers pancreatic beta-cell destruction by insulin-specific, murine CD8 T-cells.

Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates.

Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.

Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways.

Structural immunology of costimualtory and coinhibitory molecules.

B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses.

Retraction: Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity.

CD137-mediated pathogenesis from chronic hepatitis to hepatocellular carcinoma in hepatitis B virus-transgenic mice.

B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis.

CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies.

Host APCs augment in vivo expansion of donor natural regulatory T cells via B7H1/B7.1 in allogeneic recipients.

Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.

Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells.

Cell surface signaling molecules in the control of immune responses: a tide model.

B7-h2 is a costimulatory ligand for CD28 in human.

The development and functions of CD4(+) T cells expressing a transgenic TCR specific for an MHC-I-restricted tumor antigenic epitope.

Cutting edge: A monoclonal antibody specific for the programmed death-1 homolog prevents graft-versus-host disease in mouse models.

Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation.

Expression of anti-HVEM single-chain antibody on tumor cells induces tumor-specific immunity with long-term memory.

B7-H4 induces donor-specific tolerance in mouse islet allografts.

Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes.

B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies.

Herpesvirus entry mediator regulates hypoxia-inducible factor-1α and erythropoiesis in mice.

Loss of B7-H1 expression by recipient parenchymal cells leads to expansion of infiltrating donor CD8+ T cells and persistence of graft-versus-host disease.

Blockade of the B7-H1/PD-1 pathway for cancer immunotherapy.

B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation.

Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer.

The B7 homologues and their receptors in hematologic malignancies.

Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells.

Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape.

Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.

PD-1 blockage reverses immune dysfunction and hepatitis B viral persistence in a mouse animal model.

Blockade of both B7-H4 and CTLA-4 co-signaling pathways enhances mouse islet allograft survival.

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.

Durable Cancer Regression Off-treatment and Effective Re-induction Therapy with an Anti-PD-1 Antibody.

Endogenous Expression of B7-H4 Improves Long-term Murine Islet Allograft Survival.