Yue Lu

Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check.

TDRD3 is an effector molecule for arginine-methylated histone marks.

Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia.

Dnmt3a is essential for hematopoietic stem cell differentiation.

SINE retrotransposons cause epigenetic reprogramming of adjacent gene promoters.

dsPIG: a tool to predict imprinted genes from the deep sequencing of whole transcriptomes.

Stabilization of the promoter nucleosomes in nucleosome-free regions by the yeast Cyc8-Tup1 corepressor.

The epigenome of AML stem and progenitor cells.

Accuracy of RNA-Seq and its dependence on sequencing depth.

Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition.

Age-related epigenetic drift in the pathogenesis of MDS and AML.

Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation.

Integrated genetic approaches identify the molecular mechanisms of Sox4 in early B-cell development: intricate roles for RAG1/2 and CK1ε.

The Sox4/Tcf7l1 axis promotes progression of BCR-ABL-positive acute lymphoblastic leukemia.

The tumor promoting activity of the EP4 receptor for prostaglandin E2 in murine skin.

Gcn5 and PCAF negatively regulate interferon-β production through HAT-independent inhibition of TBK1.

A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy.

Tyrosine kinase inhibitors induce mesenchymal stem cell-mediated resistance in BCR-ABL+ acute lymphoblastic leukemia.

TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.

Methylome sequencing for fibrolamellar hepatocellular carcinoma depicts distinctive features.

A Molecular Portrait of High-Grade Ductal Carcinoma In Situ.

Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression.

Epigenetic synergy between decitabine and platinum derivatives.

Expanded GAA repeats impede transcription elongation through the FXN gene and induce transcriptional silencing that is restricted to the FXN locus.

LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice.

Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer.

Defining a Population of Stem-like Human Prostate Cancer Cells That Can Generate and Propagate Castration-Resistant Prostate Cancer.

Maternal Setdb1 Is Required for Meiotic Progression and Preimplantation Development in Mouse.

ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.

DNA Methylation Signature Reveals Cell Ontogeny of Renal Cell Carcinomas.

Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells.

PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.

Serum exosomal miR-4772-3p is a predictor of tumor recurrence in stage II and III colon cancer.

NANOG reprograms prostate cancer cells to castration resistance via dynamically repressing and engaging the AR/FOXA1 signaling axis.

A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome.

MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes.

Developing a Novel Two-Dimensional Culture System to Enrich Human Prostate Luminal Progenitors that Can Function as a Cell of Origin for Prostate Cancer.

RNA sequencing analyses reveal novel differentially expressed genes and pathways in pancreatic cancer.

Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance.

Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML.

Downregulation of Human Endogenous Retrovirus Type K (HERV-K) Viral RNA in Pancreatic Cancer Cells Decreases Cell Proliferation and Tumor Growth.

Transcriptional consequences of XPA disruption in human cell lines.

Caloric restriction delays age-related methylation drift.

Comprehensive analysis of gene expression patterns in Friedreich's ataxia fibroblasts by RNA sequencing reveals altered levels of protein synthesis factors and solute carriers.

Digital Restriction Enzyme Analysis of Methylation (DREAM).

GCN5 Regulates FGF Signaling and Activates Selective MYC Target Genes during Early Embryoid Body Differentiation.

Histone 2B-GFP Label-Retaining Prostate Luminal Cells Possess Progenitor Cell Properties and Are Intrinsically Resistant to Castration.

Response to "XPA is primarily cytoplasmic but is transported into the nucleus upon UV damage".

The arginine methyltransferase CARM1 represses p300•ACT•CREMτ activity and is required for spermiogenesis.

Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice.

KDM6B overexpression activates innate immune signaling and impairs hematopoiesis in mice.

Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches.

DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells.

Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases.

Combinations of Tyrosine Kinase Inhibitor and ERAD Inhibitor Promote Oxidative Stress-Induced Apoptosis through ATF4 and KLF9 in Medullary Thyroid Cancer.

USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta.

Oncogenic and osteolytic functions of histone demethylase NO66 in castration-resistant prostate cancer.

Structural basis of specific DNA binding by the transcription factor ZBTB24.

Systematic evaluation of RNA-Seq preparation protocol performance.

CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas.

KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells.

Bone morphogenetic protein 7 promotes resistance to immunotherapy.

Author Correction: Bone morphogenetic protein 7 promotes resistance to immunotherapy.

Transcriptional Activation of MYC-Induced Genes by GCN5 Promotes B-cell Lymphomagenesis.

Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas.

ATF3-Induced Mammary Tumors Exhibit Molecular Features of Human Basal-Like Breast Cancer.

Resolution of tissue signatures of therapy response in patients with recurrent GBM treated with neoadjuvant anti-PD1.

Overexpression Leads to Aberrant Signal Transduction of Cancer-Related Pathways but Is Not Sufficient to Drive Tumor Formation in Mice.

Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer.

Identification of novel susceptibility methylation loci for pancreatic cancer in a two-phase epigenome-wide association study.

Methyl-lysine readers PHF20 and PHF20L1 define two distinct gene expression-regulating NSL complexes.

Defining the mammalian coactivation of hepatic 12-h clock and lipid metabolism.

Cooperation between KDM6B overexpression and TET2 deficiency in the pathogenesis of chronic myelomonocytic leukemia.

CHD1 Promotes Sensitivity to Aurora Kinase Inhibitors by Suppressing Interaction of AURKA with Its Coactivator TPX2.

Transcriptomic Signatures of Hypomethylating Agent Failure in Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia.

The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer.

WWOX P47T partial loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration in mice phenocopying human SCAR12.

Commercial ChIP-Seq Library Preparation Kits Performed Differently for Different Classes of Protein Targets.

Comparison of pharmacological inhibitors of lysine-specific demethylase 1 in glioblastoma stem cells reveals inhibitor-specific efficacy profiles.

Cigarette smoke exposure accelerates AML progression in FLT3-ITD models.

The AT-hook is an evolutionarily conserved auto-regulatory domain of SWI/SNF required for cell lineage priming.

The SAGA acetyltransferase module is required for the maintenance of MAF and MYC oncogenic gene expression programs in multiple myeloma.

The SAGA acetyltransferase module is required for the maintenance of MAF and MYC oncogenic gene expression programs in multiple myeloma.

The ICF syndrome protein CDCA7 harbors a unique DNA binding domain that recognizes a CpG dyad in the context of a non-B DNA.

MTA-cooperative PRMT5 inhibitors enhance T cell-mediated antitumor activity in MTAP-loss tumors.

Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration.