Alan Daugherty

Mouse models of atherosclerosis.

Interleukin-18 enhances atherosclerosis in apolipoprotein E(-/-) mice through release of interferon-gamma.

Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/- mice.

Mechanisms of abdominal aortic aneurysm formation.

Interleukin-4 deficiency promotes gallstone formation.

T lymphocytes in atherosclerosis: the yin-yang of Th1 and Th2 influence on lesion formation.

Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence.

Abdominal aortic aneurysms: fresh insights from a novel animal model of the disease.

Atherosclerosis: cell biology and lipoproteins.

IFN-gamma deficiency exerts gender-specific effects on atherogenesis in apolipoprotein E-/- mice.

Macrophage-specific expression of class A scavenger receptors in LDL receptor(-/-) mice decreases atherosclerosis and changes spleen morphology.

Overexpression of SR-BI by adenoviral vector promotes clearance of apoA-I, but not apoB, in human apoB transgenic mice.

Quantification of atherosclerosis in mice.

Macrophage-expressed group IIA secretory phospholipase A2 increases atherosclerotic lesion formation in LDL receptor-deficient mice.

Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.

AGI-1067: a multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent.

Class A scavenger receptor-mediated adhesion and internalization require distinct cytoplasmic domains.

Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient mice.

Thalidomide inhibits early atherogenesis in apoE-deficient mice.

Near-infrared spectrometry of abdominal aortic aneurysm in the ApoE-/- mouse.

Role of metabolism and receptor responsiveness in the attenuated responses to Angiotensin II in mice compared to rats.

Mouse models of abdominal aortic aneurysms.

Depletion of natural killer cell function decreases atherosclerosis in low-density lipoprotein receptor null mice.

Orchidectomy, but not ovariectomy, regulates angiotensin II-induced vascular diseases in apolipoprotein E-deficient mice.

Angiotensin II-mediated development of vascular diseases.

Atherosclerosis: cell biology and lipoproteins.

Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension.

IL-5 links adaptive and natural immunity in reducing atherosclerotic disease.

Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- mice.

Angiotensin II and abdominal aortic aneurysms.

Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages.

Hypercholesterolemia stimulates angiotensin peptide synthesis and contributes to atherosclerosis through the AT1A receptor.

Dietary fat interacts with PCBs to induce changes in lipid metabolism in mice deficient in low-density lipoprotein receptor.

Aldosterone does not mediate angiotensin II-induced atherosclerosis and abdominal aortic aneurysms.

Atherosclerosis: cell biology and lipoproteins.

The use of nonsteroidal anti-inflammatory drugs (NSAIDs): a science advisory from the American Heart Association.

COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice.

Development of experimental designs for atherosclerosis studies in mice.

Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice.

Thematic review series: The immune system and atherogenesis. Cytokine regulation of macrophage functions in atherogenesis.

Zinc deficiency increases plasma lipids and atherosclerotic markers in LDL-receptor-deficient mice.

Angiotensin II infusion induces site-specific intra-laminar hemorrhage in macrophage colony-stimulating factor-deficient mice.

Atherosclerosis: cell biology and lipoproteins.

Reduction in ABCG1 in Type 2 diabetic mice increases macrophage foam cell formation.

Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.

Rapid dilation of the abdominal aorta during infusion of angiotensin II detected by noninvasive high-frequency ultrasonography.

Abdominal aortic aneurysm: pathogenesis and implications for management.

Atherosclerosis: cell biology and lipoproteins.

Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II-induced atherosclerosis and aneurysms.

Role of the renin-angiotensin system in the development of abdominal aortic aneurysms in animals and humans.

Angiotensin II increases adipose angiotensinogen expression.

Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association.

Commentary. Angiotensin converting enzyme inhibitors and aortic rupture: population based case control study.

Zinc deficiency alters lipid metabolism in LDL receptor deficient mice treated with rosiglitazone.

Atherosclerosis and arterial blood pressure in mice.

Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in mice.

Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice.

Immunostaining of mouse atherosclerotic lesions.

Translating molecular discoveries into new therapies for atherosclerosis.

Androgen increases AT1a receptor expression in abdominal aortas to promote angiotensin II-induced AAAs in apolipoprotein E-deficient mice.

Atherosclerosis: cell biology and lipoproteins.

The role of the renin-angiotensin system in aortic aneurysmal diseases.

As macrophages indulge, atherosclerotic lesions bulge.

Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice.

G2A deficiency in mice promotes macrophage activation and atherosclerosis.

Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture.

ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice.

Atherosclerosis: cell biology and lipoproteins.

Scavenger Receptor BI Protects against Septic Death through Its Role in Modulating Inflammatory Response.

Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation.

Modes of defining atherosclerosis in mouse models: relative merits and evolving standards.

Augmentation of the renin-angiotensin system by hypercholesterolemia promotes vascular diseases.

Peroxisome proliferator-activated receptor ligands reduce aortic dilatation in a mouse model of aortic aneurysm.

Atherosclerosis: cell biology and lipoproteins.

Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3.

S100A12 links to thoracic aortic aneurysms.

Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE-/- mice.

Dietary coenzyme Q10 does not protect against cigarette smoke-augmented atherosclerosis in apoE-deficient mice.

Weight loss in obese C57BL/6 mice limits adventitial expansion of established angiotensin II-induced abdominal aortic aneurysms.

Total lymphocyte deficiency attenuates AngII-induced atherosclerosis in males but not abdominal aortic aneurysms in apoE deficient mice.

Genetic variants of the Renin Angiotensin system: effects on atherosclerosis in experimental models and humans.

Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis.

In memoriam: Stewart Charles Whitman (1964-2010).

Pioglitazone-induced reductions in atherosclerosis occur via smooth muscle cell-specific interaction with PPAR{gamma}.

Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice.

Telomerase deficiency in bone marrow-derived cells attenuates angiotensin II-induced abdominal aortic aneurysm formation.

Atherosclerosis: cell biology and lipoproteins.

Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice.

Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor-/- mice.

Statins exert differential effects on angiotensin II-induced atherosclerosis, but no benefit for abdominal aortic aneurysms.

Membrane cholesterol modulates the fluid shear stress response of polymorphonuclear leukocytes via its effects on membrane fluidity.

Atherosclerosis: cell biology and lipoproteins.

Renal proximal tubule angiotensin AT1A receptors regulate blood pressure.

Prolonged infusion of angiotensin II in apoE(-/-) mice promotes macrophage recruitment with continued expansion of abdominal aortic aneurysm.

Chinese red yeast rice attenuates the development of angiotensin II-induced abdominal aortic aneurysm and atherosclerosis.

Complex pathologies of angiotensin II-induced abdominal aortic aneurysms.

Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation.

Deficiency of scavenger receptor BI leads to impaired lymphocyte homeostasis and autoimmune disorders in mice.

Urokinase-type plasminogen activator deficiency in bone marrow-derived cells augments rupture of angiotensin II-induced abdominal aortic aneurysms.

C323 of SR-BI is required for SR-BI-mediated HDL binding and cholesteryl ester uptake.

MyD88 deficiency attenuates angiotensin II-induced abdominal aortic aneurysm formation independent of signaling through Toll-like receptors 2 and 4.

Comparative effects of different modes of renin angiotensin system inhibition on hypercholesterolaemia-induced atherosclerosis.

Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice.

Regulation of Peroxisome Proliferator-Activated Receptor-γ by Angiotensin II Via Transforming Growth Factor-β1-Activated p38 Mitogen-Activated Protein Kinase in Aortic Smooth Muscle Cells.

Deficiency of receptor-associated protein attenuates angiotensin II-induced atherosclerosis in hypercholesterolemic mice without influencing abdominal aortic aneurysms.

Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms.

Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin.

Protein Kinase C-Delta Mediates Adventitial Cell Migration Through Regulation of Monocyte Chemoattractant Protein-1 Expression in a Rat Angioplasty Model.

Molecular and Pathophysiological Features of Angiotensinogen: A Mini Review.

Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms.

Atherosclerosis: cell biology and lipoproteins.

Ghrelin Receptor Deficiency does not Affect Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Null Mice.

Atherogenic and pulmonary responses of ApoE- and LDL receptor-deficient mice to sidestream cigarette smoke.

Differential effects of dietary sodium intake on blood pressure and atherosclerosis in hypercholesterolemic mice.

Involvement of the renin-angiotensin system in abdominal and thoracic aortic aneurysms.

Novel mechanisms of abdominal aortic aneurysms.

Citrullus lanatus 'sentinel' (watermelon) extract reduces atherosclerosis in LDL receptor-deficient mice.

Deficiency of angiotensin type 1a receptors in adipocytes reduces differentiation and promotes hypertrophy of adipocytes in lean mice.

Do vivarium conditions influence atherosclerotic lesion size?

Doxycycline does not influence established abdominal aortic aneurysms in angiotensin II-infused mice.

Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice.

Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms.

Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice.

Atherosclerosis: cell biology and lipoproteins.

The Vascular Research Initiatives Conference and over 25 years of conversations on the science of vascular disease.

Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms.

CD14 directs adventitial macrophage precursor recruitment: role in early abdominal aortic aneurysm formation.

PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism.

High density lipoprotein protects against polymicrobe-induced sepsis in mice.

Mineralocorticoid receptor agonists induce mouse aortic aneurysm formation and rupture in the presence of high salt.

Contributions of leukocyte angiotensin-converting enzyme to development of atherosclerosis.

Atherosclerosis: cell biology and lipoproteins.

Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway.

Noninvasive quantification of postocclusive reactive hyperemia in mouse thigh muscle by near-infrared diffuse correlation spectroscopy.

Amlodipine reduces AngII-induced aortic aneurysms and atherosclerosis in hypercholesterolemic mice.

Deficiency of endogenous acute phase serum amyloid A does not affect atherosclerotic lesions in apolipoprotein E-deficient mice.

Diverse contributions from the initial discovery of mechanisms of angiotensin II-induced oxidation in smooth muscle cells.

Aortic aneurysms in Loeys-Dietz syndrome - a tale of two pathways?

Castration of male mice prevents the progression of established angiotensin II-induced abdominal aortic aneurysms.

Shear-sensitive regulation of neutrophil flow behavior and its potential impact on microvascular blood flow dysregulation in hypercholesterolemia.

Recipients of the 2014 Early Career Investigator Awards.

Scavenger receptor BI and high-density lipoprotein regulate thymocyte apoptosis in sepsis.

Atherosclerosis: cell biology and lipoproteins.

Recent highlights of ATVB: aneurysms.

Deficiency of the NR4A orphan nuclear receptor NOR1 in hematopoietic stem cells accelerates atherosclerosis.

Angiotensin II induces region-specific medial disruption during evolution of ascending aortic aneurysms.

Mechanisms of aortic aneurysm formation: translating preclinical studies into clinical therapies.

Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms.

Smooth muscle cell deletion of low-density lipoprotein receptor-related protein 1 augments angiotensin II-induced superior mesenteric arterial and ascending aortic aneurysms.

Accelerating the pace of atherosclerosis research.

Epidermal growth factor receptor inhibitor protects against abdominal aortic aneurysm in a mouse model.

AT1 receptor antagonism to reduce aortic expansion in Marfan syndrome: lost in translation or in need of different interpretation?

Pulmonary and atherogenic effects of multi-walled carbon nanotubes (MWCNT) in apolipoprotein-E-deficient mice.

Cys18-Cys137 disulfide bond in mouse angiotensinogen does not affect AngII-dependent functions in vivo.

Atherosclerosis.

Recipients of the 2015 Early Career Investigator Awards.

Deficiency of Endogenous Acute-Phase Serum Amyloid A Protects apoE-/- Mice From Angiotensin II-Induced Abdominal Aortic Aneurysm Formation.

Atherosclerosis: cell biology and lipoproteins.

Increasing adipocyte lipoprotein lipase improves glucose metabolism in high fat diet-induced obesity.

Associations of ApoAI and ApoB-Containing Lipoproteins With AngII-Induced Abdominal Aortic Aneurysms in Mice.

Telemetric Blood Pressure Assessment in Angiotensin II-Infused ApoE-/- Mice: 28 Day Natural History and Comparison to Tail-Cuff Measurements.

Exogenous 17-β estradiol administration blunts progression of established angiotensin II-induced abdominal aortic aneurysms in female ovariectomized mice.

Platelet Inhibitors Reduce Rupture in a Mouse Model of Established Abdominal Aortic Aneurysm.

Fibroblast Angiotensin II Type 1a Receptors Contribute to Angiotensin II-Induced Medial Hyperplasia in the Ascending Aorta.

Angiotensin II and Abdominal Aortic Aneurysms: An update.

Regulatory B cells, interleukin-10, and atherosclerosis.

Abdominal aortic aneurysm: novel mechanisms and therapies.

Transforming Growth Factor-β in Thoracic Aortic Aneurysms: Good, Bad, or Irrelevant?

Recipients of the 2017 Early Career Investigator Awards.

Smooth Muscle Cells Derived From Second Heart Field and Cardiac Neural Crest Reside in Spatially Distinct Domains in the Media of the Ascending Aorta-Brief Report.