William G. Lowrie Department of Chemical and Biomolecular Engineering,
College of Engineering,
William G. Lowrie Department of Chemical and Biomolecular Engineering, College of Engineering
Andre F. Palmer has not added Biography.
If you are Andre F. Palmer and would like to personalize this page please email our Author Liaison for assistance.
Self-assembled poly(butadiene)-b-poly(ethylene oxide) polymersomes as paclitaxel carriers.
Biotechnology progress Jan-Feb, 2007 | Pubmed ID: 17269699
Hemoglobin-based O2 carrier O2 affinity and capillary inlet pO2 are important factors that influence O2 transport in a capillary.
Biotechnology progress Jul-Aug, 2007 | Pubmed ID: 17555329
Purification of bovine hemoglobin via fast performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Sep, 2007 | Pubmed ID: 17581802
Preparation of ultrapure bovine and human hemoglobin by anion exchange chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences May, 2008 | Pubmed ID: 18359279
Biocompatible and biodegradable polymersome encapsulated hemoglobin: a potential oxygen carrier.
Bioconjugate chemistry May, 2008 | Pubmed ID: 18442283
Site-selective glycosylation of hemoglobin on Cys beta93.
Bioconjugate chemistry Nov, 2008 | Pubmed ID: 18925771
Hemoglobin-based oxygen carrier and convection enhanced oxygen transport in a hollow fiber bioreactor.
Biotechnology and bioengineering Apr, 2009 | Pubmed ID: 19072844
Tangential flow filtration of hemoglobin.
Biotechnology progress Jan-Feb, 2009 | Pubmed ID: 19224583
Perfluorocarbon facilitated O(2) transport in a hepatic hollow fiber bioreactor.
Biotechnology progress Sep-Oct, 2009 | Pubmed ID: 19565662
Purification of hemoglobin by tangential flow filtration with diafiltration.
Biotechnology progress Sep-Oct, 2009 | Pubmed ID: 19621471
The quaternary structure of tetrameric hemoglobin regulates the oxygen affinity of polymerized hemoglobin.
Biotechnology progress Nov-Dec, 2009 | Pubmed ID: 19725116
Effects of the molecular mass of tense-state polymerized bovine hemoglobin on blood pressure and vasoconstriction.
Journal of applied physiology (Bethesda, Md. : 1985) Nov, 2009 | Pubmed ID: 19745190
Mixtures of hemoglobin-based oxygen carriers and perfluorocarbons exhibit a synergistic effect in oxygenating hepatic hollow fiber bioreactors.
Biotechnology and bioengineering Feb, 2010 | Pubmed ID: 19816963
Large scale production of vesicles by hollow fiber extrusion: a novel method for generating polymersome encapsulated hemoglobin dispersions.
Langmuir : the ACS journal of surfaces and colloids Apr, 2010 | Pubmed ID: 20000689
Tissue oxygenation after exchange transfusion with ultrahigh-molecular-weight tense- and relaxed-state polymerized bovine hemoglobins.
American journal of physiology. Heart and circulatory physiology Mar, 2010 | Pubmed ID: 20061539
Functional comparison of hemoglobin purified by different methods and their biophysical implications.
Biotechnology and bioengineering May, 2010 | Pubmed ID: 20073089
Synthesis, biophysical properties and pharmacokinetics of ultrahigh molecular weight tense and relaxed state polymerized bovine hemoglobins.
Biomaterials May, 2010 | Pubmed ID: 20149433
High throughput assembly of spatially controlled 3D cell clusters on a micro/nanoplatform.
Lab on a chip Mar, 2010 | Pubmed ID: 20221567
Hemoglobin regulates the metabolic, synthetic, detoxification, and biotransformation functions of hepatoma cells cultured in a hollow fiber bioreactor.
Tissue engineering. Part A Oct, 2010 | Pubmed ID: 20528678
Hemoglobin regulates the metabolic and synthetic function of rat insulinoma cells cultured in a hollow fiber bioreactor.
Biotechnology and bioengineering Oct, 2010 | Pubmed ID: 20552668
Polymerization of human hemoglobin using the crosslinker 1,11-bis(maleimido)triethylene glycol for use as an oxygen carrier.
Biotechnology progress Sep-Oct, 2010 | Pubmed ID: 20564360
Biophysical properties and oxygenation potential of high-molecular-weight glutaraldehyde-polymerized human hemoglobins maintained in the tense and relaxed quaternary states.
Tissue engineering. Part A Apr, 2011 | Pubmed ID: 20979534
Purification of hemoglobin from red blood cells using tangential flow filtration and immobilized metal ion affinity chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Jan, 2011 | Pubmed ID: 21195679
Effects of T- and R-state stabilization on deoxyhemoglobin-nitrite reactions and stimulation of nitric oxide signaling.
Nitric oxide : biology and chemistry Aug, 2011 | Pubmed ID: 21277987
Synthesis and biophysical properties of polymerized human serum albumin.
Biotechnology progress Jan-Feb, 2011 | Pubmed ID: 21312376
Development of a dichloroacetic acid-hemoglobin conjugate as a potential targeted anti-cancer therapeutic.
Biotechnology and bioengineering Jun, 2011 | Pubmed ID: 21328317
Small-volume resuscitation from hemorrhagic shock using high-molecular-weight tense-state polymerized hemoglobins.
The Journal of trauma Oct, 2011 | Pubmed ID: 21336190
Structure of Greyhound hemoglobin: origin of high oxygen affinity.
Acta crystallographica. Section D, Biological crystallography May, 2011 | Pubmed ID: 21543841
Synthesis, biophysical properties, and oxygenation potential of variable molecular weight glutaraldehyde-polymerized bovine hemoglobins with low and high oxygen affinity.
Biotechnology progress Apr, 2011 | Pubmed ID: 21584950
Simple method for preparing poly(ethylene glycol)-surface-conjugated liposome-encapsulated hemoglobins: physicochemical properties, long-term storage stability, and their reactions with O2, CO, and NO.
Langmuir : the ACS journal of surfaces and colloids Jul, 2011 | Pubmed ID: 21678920
Liposomes surface conjugated with human hemoglobin target delivery to macrophages.
Biotechnology and bioengineering Mar, 2012 | Pubmed ID: 22012493
Small-volume resuscitation from hemorrhagic shock with polymerized human serum albumin.
The American journal of emergency medicine Nov, 2011 | Pubmed ID: 22100469
Simulation of NO and O(2) transport facilitated by polymerized hemoglobin solutions in an arteriole that takes into account wall shear stress-induced NO production.
Biophysical chemistry Jan, 2012 | Pubmed ID: 22285312
Hypervolemic infusion of Lumbricus terrestris erythrocruorin purified by tangential-flow filtration.
Transfusion Feb, 2012 | Pubmed ID: 22304397
Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a guinea pig model.
Toxicological sciences : an official journal of the Society of Toxicology Jun, 2012 | Pubmed ID: 22416071
Encapsulation of hemoglobin inside liposomes surface conjugated with poly(ethylene glycol) attenuates their reactions with gaseous ligands and regulates nitric oxide dependent vasodilation.
Biotechnology progress May-Jun, 2012 | Pubmed ID: 22467599
Site-selective glycosylation of hemoglobin with variable molecular weight oligosaccharides: potential alternative to PEGylation.
Journal of the American Chemical Society May, 2012 | Pubmed ID: 22489605
Hemoglobin encapsulated poly(ethylene glycol) surface conjugated vesicles attenuate vasoactivity of cell-free hemoglobin.
Current drug discovery technologies Sep, 2012 | Pubmed ID: 22564169
High-efficiency matrix modulus-induced cardiac differentiation of human mesenchymal stem cells inside a thermosensitive hydrogel.
Acta biomaterialia Oct, 2012 | Pubmed ID: 22729021
The Reactivity of Polymersome Encapsulated Hemoglobin with Physiologically Important Gaseous Ligands: Oxygen, Carbon Monoxide and Nitric Oxide.
Macromolecules Mar, 2012 | Pubmed ID: 22865934
Oxygen delivery during extreme anemia with ultra-pure earthworm hemoglobin.
Life sciences Oct, 2012 | Pubmed ID: 22982347
Addition of ascorbic acid solution to stored murine red blood cells increases posttransfusion recovery and decreases microparticles and alloimmunization.
Transfusion Oct, 2013 | Pubmed ID: 23384196
Scaffold architecture controls insulinoma clustering, viability, and insulin production.
Tissue engineering. Part A Jul, 2014 | Pubmed ID: 24410263
Blood substitutes.
Annual review of biomedical engineering Jul, 2014 | Pubmed ID: 24819476
Biophysical Properties of Lumbricus terrestris Erythrocruorin and Its Potential Use as a Red Blood Cell Substitute.
Journal of functional biomaterials Jan, 2012 | Pubmed ID: 24956515
Hemoglobin regulates the migration of glioma cells along poly(ε-caprolactone)-aligned nanofibers.
Biotechnology progress Sep-Oct, 2014 | Pubmed ID: 25044995
Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species-pharmacokinetic and therapeutic implications.
Frontiers in physiology , 2014 | Pubmed ID: 25346694
Evaluating the capacity to generate and preserve nitric oxide bioactivity in highly purified earthworm erythrocruorin: a giant polymeric hemoglobin with potential blood substitute properties.
The Journal of biological chemistry Jan, 2015 | Pubmed ID: 25371199
Methemoglobin is an endogenous toll-like receptor 4 ligand-relevance to subarachnoid hemorrhage.
International journal of molecular sciences Mar, 2015 | Pubmed ID: 25751721
Cotransplantation of Polymerized Hemoglobin Reduces β-Cell Hypoxia and Improves β-Cell Function in Intramuscular Islet Grafts.
Transplantation Oct, 2015 | Pubmed ID: 26426924
Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis.
American journal of respiratory and critical care medicine 05, 2016 | Pubmed ID: 26694989
Transfusion with packed red blood cells while awaiting lung transplantation is associated with reduced survival after lung transplantation.
Clinical transplantation Dec, 2016 | Pubmed ID: 27653312
Quantification of Active Apohemoglobin Heme-Binding Sites via Dicyanohemin Incorporation.
Biochemistry 10, 2017 | Pubmed ID: 28846391
The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: A theoretical and experimental study.
PloS one , 2018 | Pubmed ID: 29414985
Single cell analysis of aged RBCs: quantitative analysis of the aged cells and byproducts.
The Analyst Jan, 2019 | Pubmed ID: 30617361
A Subpopulation of Monocytes in Normal Human Blood Has Significant Magnetic Susceptibility: Quantification and Potential Implications.
Cytometry. Part A : the journal of the International Society for Analytical Cytology May, 2019 | Pubmed ID: 30958642
An Hb-mediated circulating macrophage contributing to pulmonary vascular remodeling in sickle cell disease.
JCI insight 08, 2019 | Pubmed ID: 31391342
Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm.
The Journal of clinical investigation 12, 2019 | Pubmed ID: 31454333
Novel manufacturing method for producing apohemoglobin and its biophysical properties.
Biotechnology and bioengineering 01, 2020 | Pubmed ID: 31612988
Controlled Polymerization and Ultrafiltration Increase the Consistency of Polymerized Hemoglobin for Use as an Oxygen Carrier.
Bioconjugate chemistry 03, 2020 | Pubmed ID: 31868349
Quantification of the Mean and Distribution of Hemoglobin Content in Normal Human Blood Using Cell Tracking Velocimetry.
Analytical chemistry Jan, 2020 | Pubmed ID: 31874030
Injectable biodegradable bi-layered capsule for sustained delivery of bevacizumab in treating wet age-related macular degeneration.
Journal of controlled release : official journal of the Controlled Release Society 04, 2020 | Pubmed ID: 31981659
Resuscitation From Hemorrhagic Shock With Fresh and Stored Blood and Polymerized Hemoglobin.
Shock (Augusta, Ga.) 10, 2020 | Pubmed ID: 32097242
Poly(ethylene glycol) Surface-Conjugated Apohemoglobin as a Synthetic Heme Scavenger.
Biomacromolecules 06, 2020 | Pubmed ID: 32186855
Apohemoglobin-haptoglobin complex attenuates the pathobiology of circulating acellular hemoglobin and heme.
American journal of physiology. Heart and circulatory physiology 05, 2020 | Pubmed ID: 32302494
Tangential flow filtration of haptoglobin.
Biotechnology progress 09, 2020 | Pubmed ID: 32348635
Anti-inflammatory effects of haptoglobin on LPS-stimulated macrophages: Role of HMGB1 signaling and implications in chronic wound healing.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 07, 2020 | Pubmed ID: 32428978
Targeted Myoglobin Delivery as a Strategy for Enhancing the Sensitivity of Hypoxic Cancer Cells to Radiation.
iScience Jun, 2020 | Pubmed ID: 32464594
Comprehensive characterization of tense and relaxed quaternary state glutaraldehyde polymerized bovine hemoglobin as a function of cross-link density.
Biotechnology and bioengineering 08, 2020 | Pubmed ID: 32472694
Balance between oxygen transport and blood rheology during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin.
Journal of applied physiology (Bethesda, Md. : 1985) 07, 2020 | Pubmed ID: 32552431
Apohemoglobin-haptoglobin complexes attenuate the hypertensive response to low-molecular-weight polymerized hemoglobin.
Blood advances 06, 2020 | Pubmed ID: 32559292
Hyperferritinemia in critically ill COVID-19 patients - Is ferritin the product of inflammation or a pathogenic mediator?
Clinica chimica acta; international journal of clinical chemistry Oct, 2020 | Pubmed ID: 32579952
Polymerized human hemoglobin facilitated modulation of tumor oxygenation is dependent on tumor oxygenation status and oxygen affinity of the hemoglobin-based oxygen carrier.
Scientific reports 07, 2020 | Pubmed ID: 32647211
Tumor vascular status controls oxygen delivery facilitated by infused polymerized hemoglobins with varying oxygen affinity.
PLoS computational biology 08, 2020 | Pubmed ID: 32817659
Safety profile of high molecular weight polymerized hemoglobins.
Transfusion 01, 2021 | Pubmed ID: 33104250
Polymerized human hemoglobin increases the effectiveness of cisplatin-based chemotherapy in non-small cell lung cancer.
Oncotarget Oct, 2020 | Pubmed ID: 33144918
Vessel-on-a-chip models for studying microvascular physiology, transport, and function in vitro.
American journal of physiology. Cell physiology 01, 2021 | Pubmed ID: 33176110
Early Intervention in Ischemic Tissue with Oxygen Nanocarriers Enables Successful Implementation of Restorative Cell Therapies.
Cellular and molecular bioengineering Oct, 2020 | Pubmed ID: 33184576
Synthesis of Hemoglobin-Based Oxygen Carrier Nanoparticles By Desolvation Precipitation.
Langmuir : the ACS journal of surfaces and colloids 12, 2020 | Pubmed ID: 33205655
Purification of Mega-Hemoglobin for Diverse Oxygen Therapeutic Applications.
ACS biomaterials science & engineering 09, 2020 | Pubmed ID: 33313397
Resuscitation from hemorrhagic shock after traumatic brain injury with polymerized hemoglobin.
Scientific reports 01, 2021 | Pubmed ID: 33510204
High fat high sucrose diet-induced dyslipidemia in guinea pigs.
Journal of applied physiology (Bethesda, Md. : 1985) 04, 2021 | Pubmed ID: 33703947
Purification and analysis of a protein cocktail capable of scavenging cell-free hemoglobin, heme, and iron.
Transfusion 06, 2021 | Pubmed ID: 33817808
Structural Stability and Biophysical Properties of the Mega-Protein Erythrocruorin Are Regulated by Polyethylene Glycol Surface Coverage.
Biomacromolecules 05, 2021 | Pubmed ID: 33821616
Immunomagnetic sequential ultrafiltration (iSUF) platform for enrichment and purification of extracellular vesicles from biofluids.
Scientific reports 04, 2021 | Pubmed ID: 33850163
Polymerized albumin restores impaired hemodynamics in endotoxemia and polymicrobial sepsis.
Scientific reports 05, 2021 | Pubmed ID: 34035380
Magnetophoretic and spectral characterization of oxyhemoglobin and deoxyhemoglobin: Chemical versus enzymatic processes.
PloS one , 2021 | Pubmed ID: 34478473
Biophysical properties of tense quaternary state polymerized human hemoglobins bracketed between 500 kDa and 0.2 μm in size.
Biotechnology progress Oct, 2021 | Pubmed ID: 34626100
Tangential flow filtration facilitated fractionation and PEGylation of low and high-molecular weight polymerized hemoglobins and their biophysical properties.
Biotechnology and bioengineering Oct, 2021 | Pubmed ID: 34672363
Yong Gyu Lee1,2,
Jung-Lye Kim1,2,
Andre F. Palmer3,
Brenda F. Reader4,
Jianjie Ma1,
Sylvester M. Black2,4,
Bryan A. Whitson1,2
1Department of Surgery Division of Cardiac Surgery, The Ohio State University Wexner Medical Center,
2The Collaboration for Organ Perfusion, Protection, Engineering and Regeneration (COPPER) Laboratory, The Ohio State University College of Medicine,
3William G. Lowrie Department of Chemical and Biomolecular Engineering, College of Engineering, The Ohio State University,
4Comprehensive Transplant Center, The Ohio State University Wexner Medical Center
ABOUT JoVE
Copyright © 2024 MyJoVE Corporation. All rights reserved