Arnim Pause

Signal transduction. Protein synthesis and oncogenesis meet again.

Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.

Hepatitis C therapeutics: current status and emerging strategies.

An NS3 serine protease inhibitor abrogates replication of subgenomic hepatitis C virus RNA.

Complete translation of the hepatitis C virus genome in vitro: membranes play a critical role in the maturation of all virus proteins except for NS3.

Hepatitis C virus NS2/3 processing is required for NS3 stability and viral RNA replication.

Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis.

Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17.

The hepatitis C virus NS2/3 protease.

The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a U-rich-element-dependent manner.

eEF1A is a novel component of the mammalian nuclear protein export machinery.

Investigation of a role for lysine residues in non-structural proteins 2 and 2/3 of the hepatitis C virus for their degradation and virus assembly.

HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain.

Expression analysis and essential role of the putative tyrosine phosphatase His-domain-containing protein tyrosine phosphatase (HD-PTP).

Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase.

The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein.

An oxygen-regulated switch in the protein synthesis machinery.

Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin.

Pseudophosphatases: methods of analysis and physiological functions.

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

Canadian guideline on genetic screening for hereditary renal cell cancers.

The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation.

Folliculin regulates ampk-dependent autophagy and metabolic stress survival.

The ever-evolving role of mTOR in translation.