Eleonora Mezzaroma

Pharmacologic inhibition of phosphoinositide 3-kinase gamma (PI3Kγ) promotes infarct resorption and prevents adverse cardiac remodeling after myocardial infarction in mice.

Right ventricular dysfunction following acute myocardial infarction in the absence of pulmonary hypertension in the mouse.

Left ventricular systolic dysfunction induced by ventricular ectopy: a novel model for premature ventricular contraction-induced cardiomyopathy.

Alpha-1 antitrypsin inhibits caspase-1 and protects from acute myocardial ischemia-reperfusion injury.

Altered oxido-reductive state in the diabetic heart: loss of cardioprotection due to protein disulfide isomerase.

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse.

Alterations in the interleukin-1/interleukin-1 receptor antagonist balance modulate cardiac remodeling following myocardial infarction in the mouse.

A mouse model of radiation-induced cardiomyopathy.

Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure.

Recombinant human interleukin-1 receptor antagonist provides cardioprotection during myocardial ischemia reperfusion in the mouse.

GS-6201, a selective blocker of the A2B adenosine receptor, attenuates cardiac remodeling after acute myocardial infarction in the mouse.

Interleukin-1β blockade improves cardiac remodelling after myocardial infarction without interrupting the inflammasome in the mouse.

Inhibition of apoptosis signal-regulating kinase 1 reduces myocardial ischemia-reperfusion injury in the mouse.

Comparative cardiac toxicity of anthracyclines in vitro and in vivo in the mouse.

Targeting interleukin-1 in heart disease.

A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse.

Formation of the inflammasome in acute myocarditis.

Interleukin-18 mediates interleukin-1-induced cardiac dysfunction.

Interleukin-18 as a therapeutic target in acute myocardial infarction and heart failure.

Induction of microRNA-21 with exogenous hydrogen sulfide attenuates myocardial ischemic and inflammatory injury in mice.

Letter by Mezzaroma, et al regarding article, "NLRP3 inflammasome as a therapeutic target in myocardial infarction".

Interleukin-1β blockade improves left ventricular systolic/diastolic function and restores contractility reserve in severe ischemic cardiomyopathy in the mouse.

Response to letter regarding article, "targeting interleukin-1 in heart disease".

The inflammasome in myocardial injury and cardiac remodeling.

Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart.

Effects of dimethyl sulfoxide on the NLRP3 inflammasome.

Role of Interleukin-1 in Radiation-Induced Cardiomyopathy.

Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse.

A high-sugar and high-fat diet impairs cardiac systolic and diastolic function in mice.

A mouse model of heart failure with preserved ejection fraction due to chronic infusion of a low subpressor dose of angiotensin II.

Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia-reperfusion in the mouse.

Recombinant Human Alpha-1 Antitrypsin-Fc Fusion Protein Reduces Mouse Myocardial Inflammatory Injury After Ischemia-Reperfusion Independent of Elastase Inhibition.

Targeting the Innate Immune Response to Improve Cardiac Graft Recovery after Heart Transplantation: Implications for the Donation after Cardiac Death.

Biomarkers of cardiac injury in patients undergoing thoracic radiation therapy.

IPW-5371 Proves Effective as a Radiation Countermeasure by Mitigating Radiation-Induced Late Effects.

A Preclinical Translational Study of the Cardioprotective Effects of Plasma-Derived Alpha-1 Anti-trypsin in Acute Myocardial Infarction.

Reduction of Myocardial Ischemia-Reperfusion Injury by Inhibiting Interleukin-1 Alpha.

Dietary Fat, Sugar Consumption, and Cardiorespiratory Fitness in Patients With Heart Failure With Preserved Ejection Fraction.

Low-Density Lipoprotein Receptor-Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction.

An Orally Available NLRP3 Inflammasome Inhibitor Prevents Western Diet-Induced Cardiac Dysfunction in Mice.

The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse.

NLRP3 Inflammasome in Acute Myocardial Infarction.

Determinants of Cardiorespiratory Fitness Following Thoracic Radiotherapy in Lung or Breast Cancer Survivors.

Targeting the NLRP3 inflammasome to reduce warm ischemic injury in donation after circulatory death heart.

Modulation of Interleukin-1 and -18 Mediated Injury in Donation after Circulatory Death Mouse Hearts.

The Role of NLRP3 Inflammasome in Pericarditis: Potential for Therapeutic Approaches.

NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases.

Mitigation of Radiation-Induced Lung and Heart Injuries in Mice by Oral Sepiapterin after Irradiation.

Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177 (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction.

Refining murine heterotopic heart transplantation: A model to study ischemia and reperfusion injury in donation after circulatory death hearts.

Improving circulatory death donor heart function: A novel approach.

Targeting the NLRP3 inflammasome in cardiovascular diseases.

The inflammasome in heart failure.

The interleukin-1 receptor type I promotes the development of aging-associated cardiomyopathy in mice.

Assessment of machine perfusion conditions for the donation after circulatory death heart preservation.