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Koch Institute for Integrative Cancer Research
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Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens.
Nature protocols Dec, 2015 | Pubmed ID: 26584444
Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors.
Angewandte Chemie (International ed. in English) Sep, 2016 | Pubmed ID: 27554600
In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease.
Science translational medicine Jul, 2017 | Pubmed ID: 28724577
In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax Hypnozoites.
Cell host & microbe Mar, 2018 | Pubmed ID: 29478773
Protease activity sensors noninvasively classify bacterial infections and antibiotic responses.
EBioMedicine Dec, 2018 | Pubmed ID: 30503861
Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers.
Cell metabolism Mar, 2019 | Pubmed ID: 30840913
Non-viral delivery of CRISPR/Cas9 complex using CRISPR-GPS nanocomplexes.
Nanoscale Nov, 2019 | Pubmed ID: 31670340
Urinary detection of lung cancer in mice via noninvasive pulmonary protease profiling.
Science translational medicine Apr, 2020 | Pubmed ID: 32238573
Controlled Apoptosis of Stromal Cells to Engineer Human Microlivers.
Advanced functional materials Nov, 2020 | Pubmed ID: 33776613
Microenvironment-triggered multimodal precision diagnostics.
Nature materials Oct, 2021 | Pubmed ID: 34267368
Identification of NQO2 As a Protein Target in Small Molecule Modulation of Hepatocellular Function.
ACS chemical biology Sep, 2021 | Pubmed ID: 34427427
Synthetic Circuit-Driven Expression of Heterologous Enzymes for Disease Detection.
ACS synthetic biology Sep, 2021 | Pubmed ID: 34464083
Virtual Undergraduate Research Experiences: More Than a Pandemic Stopgap.
Med (New York, N.Y.) Feb, 2021 | Pubmed ID: 35187514
A single-cell liver atlas of Plasmodium vivax infection.
Cell host & microbe Jul, 2022 | Pubmed ID: 35443155
A vascularized model of the human liver mimics regenerative responses.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2022 | Pubmed ID: 35763565
Conditional Antimicrobial Peptide Therapeutics.
ACS nano Oct, 2022 | Pubmed ID: 35980829
CRISPR-Cas-amplified urinary biomarkers for multiplexed and portable cancer diagnostics.
Nature nanotechnology Jul, 2023 | Pubmed ID: 37095220
Massachusetts Institute of Technology
Howard Hughes Medical Institute
Audrey E. Van Heest1,
Feiyang Deng1,
Renee T. Zhao2,
Nour Saida Harzallah2,3,
Heather E. Fleming3,4,
Sangeeta N. Bhatia2,3,4,5,6,7,8,
Liangliang Hao1,2,3
1Department of Biomedical Engineering, Boston University,
2Institute for Medical Engineering and Science, Massachusetts Institute of Technology,
3Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology,
4, Howard Hughes Medical Institute,
5, Broad Institute of Massachusetts Institute of Technology and Harvard,
6Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology,
7Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology,
8Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
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