Irmgard Tegeder

Drug interactions with patient-controlled analgesia.

Time course of 8-methoxypsoralen concentrations in skin and plasma after topical (bath and cream) and oral administration of 8-methoxypsoralen.

Tissue distribution of imipenem in critically ill patients.

The influence of inhibition of probenecid sensitive transporters on the central nervous system (CNS) uptake and the antinociceptive activity of morphine-6-glucuronide in rats.

Dual effects of spinally delivered 8-bromo-cyclic guanosine mono-phosphate (8-bromo-cGMP) in formalin-induced nociception in rats.

Increased CNS uptake and enhanced antinociception of morphine-6-glucuronide in rats after inhibition of P-glycoprotein.

Validation of a new fluorogenic real-time PCR assay for detection of CYP2C9 allelic variants and CYP2C9 allelic distribution in a German population.

Spatial distribution of 8-methoxypsoralen penetration into human skin after systemic or topical administration.

Opposite effects of rofecoxib on nuclear factor-kappaB and activating protein-1 activation.

Inhibition of cyclic guanosine 5'-monophosphate-dependent protein kinase I (PKG-I) in lumbar spinal cord reduces formalin-induced hyperalgesia and PKG upregulation.

Peripheral opioid analgesia in experimental human pain models.

G protein-independent G1 cell cycle block and apoptosis with morphine in adenocarcinoma cells: involvement of p53 phosphorylation.

Cisplatin tumor concentrations after intra-arterial cisplatin infusion or embolization in patients with oral cancer.

Activation of c-Jun-N-terminal-kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers.

Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain.

Determination of 8-methoxypsoralen in human plasma, and microdialysates using liquid chromatography-tandem mass spectrometry.

Protein associated with Myc (PAM) is involved in spinal nociceptive processing.

Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.

Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats.

The calpain inhibitor MDL 28170 prevents inflammation-induced neurofilament light chain breakdown in the spinal cord and reduces thermal hyperalgesia.

Opioids as modulators of cell death and survival--unraveling mechanisms and revealing new indications.

Essential role of the synaptic vesicle protein synapsin II in formalin-induced hyperalgesia and glutamate release in the spinal cord.

Comparative proteomic analysis of the rat spinal cord in inflammatory and neuropathic pain models.

Cardiovascular risk with cyclooxygenase inhibitors: general problem with substance specific differences?

Pathophysiology and treatment of pain in joint disease.

GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence.

Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms.

Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors.

The impact of CREB and its phosphorylation at Ser142 on inflammatory nociception.

Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats.

Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain.

Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats.

Reduced hyperalgesia in homozygous carriers of a GTP cyclohydrolase 1 haplotype.

Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk.

GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.

Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn.

cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I.

Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice.

Current evidence for a modulation of low back pain by human genetic variants.

No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing.

Genetic modulation of the pharmacological treatment of pain.

Analgesic efficacy of tramadol, pregabalin and ibuprofen in menthol-evoked cold hyperalgesia.

Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity.

R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids.

Inter-strain differences of serotonergic inhibitory pain control in inbred mice.

Opioid-mediated drug actions cannot be concluded from naloxone induced reversal of anti-nociceptive effects in behavioural tests only.

Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice.

SNO-ing at the nociceptive synapse?

Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain.

Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice.

Emerging country pharmacology: a 10-year perspective from Naunyn-Schmiedeberg's Archives of Pharmacology.

CNGA3: a target of spinal nitric oxide/cGMP signaling and modulator of inflammatory pain hypersensitivity.

The protein kinase IKKε is a potential target for the treatment of inflammatory hyperalgesia.

Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization.

Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity.

Inhibitor kappa B kinase beta dependent cytokine upregulation in nociceptive neurons contributes to nociceptive hypersensitivity after sciatic nerve injury.

Protein S-nitrosylation and denitrosylation in the mouse spinal cord upon injury of the sciatic nerve.

Inhibition of GTP cyclohydrolase reduces cancer pain in mice and enhances analgesic effects of morphine.

Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages.

Author's reply to Kapoor S. GTP cyclohydrolase and cancer pain.

Peripheral nerve injury produces a sustained shift in the balance between glutamate release and uptake in the dorsal horn of the spinal cord.

Anandamide deficiency and heightened neuropathic pain in aged mice.

Dichotomy of CCL21 and CXCR3 in nerve injury-evoked and autoimmunity-evoked hyperalgesia.

Exogenous delta⁹-tetrahydrocannabinol influences circulating endogenous cannabinoids in humans.

Hypoxia-inducible factor 1 regulates heat and cold pain sensitivity and persistence.

Learning and memory with neuropathic pain: impact of old age and progranulin deficiency.

R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice.

"Disease modifying nutricals" for multiple sclerosis.

Regulation of circulating endocannabinoids associated with cancer and metastases in mice and humans.

Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.

COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex.

Redoxins in peripheral neurons after sciatic nerve injury.

Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP.

Expression and regulation of redoxins at nociceptive signaling sites after sciatic nerve injury in mice.

Endocannabinoids as Guardians of Metastasis.

Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling.

Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy.

Progranulin promotes peripheral nerve regeneration and reinnervation: role of notch signaling.

Progranulin protects against exaggerated axonal injury and astrogliosis following traumatic brain injury.

Yeast-2-Hybrid data file showing progranulin interactions in human fetal brain and bone marrow libraries.

Data file of a deep proteome analysis of the prefrontal cortex in aged mice with progranulin deficiency or neuronal overexpression of progranulin.

Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain.

R-Flurbiprofen Traps Prostaglandins within Cells by Inhibition of Multidrug Resistance-Associated Protein-4.