Joan Mecsas

Identification of attenuated Yersinia pseudotuberculosis strains and characterization of an orogastric infection in BALB/c mice on day 5 postinfection by signature-tagged mutagenesis.

Use of signature-tagged mutagenesis in pathogenesis studies.

Requirement of the Yersinia pseudotuberculosis effectors YopH and YopE in colonization and persistence in intestinal and lymph tissues.

The proinflammatory response induced by wild-type Yersinia pseudotuberculosis infection inhibits survival of yop mutants in the gastrointestinal tract and Peyer's patches.

Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine.

A non-invasive quantitative assay to measure murine intestinal inflammation using the neutrophil marker lactoferrin.

Yersinia has a tropism for B and T cell zones of lymph nodes that is independent of the type III secretion system.

Mutations in the Yersinia pseudotuberculosis type III secretion system needle protein, YscF, that specifically abrogate effector translocation into host cells.

Intranasal inoculation of mice with Yersinia pseudotuberculosis causes a lethal lung infection that is dependent on Yersinia outer proteins and PhoP.

Oral inoculation with Type III secretion mutants of Yersinia pseudotuberculosis provides protection from oral, intraperitoneal, or intranasal challenge with virulent Yersinia.

Self-regulation of Candida albicans population size during GI colonization.

Effect of age on susceptibility to Salmonella Typhimurium infection in C57BL/6 mice.

CD8(+) T cells restrict Yersinia pseudotuberculosis infection: bypass of anti-phagocytosis by targeting antigen-presenting cells.

Effect of MarA-like proteins on antibiotic resistance and virulence in Yersinia pestis.

The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infection.

ROS-inhibitory activity of YopE is required for full virulence of Yersinia in mice.

A dominant-negative needle mutant blocks type III secretion of early but not late substrates in Yersinia.

The C-terminal tail of Yersinia pseudotuberculosis YopM is critical for interacting with RSK1 and for virulence.

Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis.

Small molecule inhibitors of LcrF, a Yersinia pseudotuberculosis transcription factor, attenuate virulence and limit infection in a murine pneumonia model.

Development of a vaccinia virus based reservoir-targeted vaccine against Yersinia pestis.

Yersinia pestis AcrAB-TolC in antibiotic resistance and virulence.

The NLRP12 inflammasome recognizes Yersinia pestis.

Identification of MrtAB, an ABC transporter specifically required for Yersinia pseudotuberculosis to colonize the mesenteric lymph nodes.

A mutant with aberrant extracellular LcrV-YscF interactions fails to form pores and translocate Yop effector proteins but retains the ability to trigger Yop secretion in response to host cell contact.

Adhesins and host serum factors drive Yop translocation by yersinia into professional phagocytes during animal infection.

Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection.

Yersinia pseudotuberculosis uses Ail and YadA to circumvent neutrophils by directing Yop translocation during lung infection.

Mutations in the Pseudomonas aeruginosa needle protein gene pscF confer resistance to phenoxyacetamide inhibitors of the type III secretion system.

Intestinal alkaline phosphatase deficiency leads to lipopolysaccharide desensitization and faster weight gain.

Robust bioengineered 3D functional human intestinal epithelium.

A Single Bacterial Immune Evasion Strategy Dismantles Both MyD88 and TRIF Signaling Pathways Downstream of TLR4.

Bacterial Secretion Systems: An Overview.

Beyond Antibiotics: New Therapeutic Approaches for Bacterial Infections.

Klebsiella pneumoniae: Going on the Offense with a Strong Defense.

Inhibition of the Injectisome and Flagellar Type III Secretion Systems by INP1855 Impairs Pseudomonas aeruginosa Pathogenicity and Inflammasome Activation.

Fis Is Essential for Yersinia pseudotuberculosis Virulence and Protects against Reactive Oxygen Species Produced by Phagocytic Cells during Infection.

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.

Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide.

Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance.

A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage.

Editorial overview: Host-pathogen interactions shaped through evolutionary and regulatory processes.

Pre-colonization with the commensal fungus Candida albicans reduces murine susceptibility to Clostridium difficile infection.

Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target.

New Age Strategies To Reconstruct Mucosal Tissue Colonization and Growth in Cell Culture Systems.

Amino acid biosynthetic pathways are required for growth in immunocompromised lungs and are druggable targets during infection.

Detection of Cells Translocated with Yersinia Yops in Infected Tissues Using β-Lactamase Fusions.

Unraveling neutrophil- interactions during tissue infection.