Klaus Ley

Automatic tracking of rolling leukocytes in vivo.

Control of leukocyte rolling velocity in TNF-alpha-induced inflammation by LFA-1 and Mac-1.

L-selectin is required for fMLP- but not C5a-induced margination of neutrophils in pulmonary circulation.

P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow.

Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase.

Chemokines and chemokine receptors in leukocyte trafficking.

Binding of function-blocking mAbs to mouse and human P-selectin glycoprotein ligand-1 peptides with and without tyrosine sulfation.

Integration of inflammatory signals by rolling neutrophils.

Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury.

Severely reduced neutrophil adhesion and impaired host defense against fecal and commensal bacteria in CD18-/-P-selectin-/- double null mice.

Vascular protection by estrogen in ischemia-reperfusion injury requires endothelial nitric oxide synthase.

T cell requirement for development of chronic ulcerative dermatitis in E- and P-selectin-deficient mice.

Sialyltransferase specificity in selectin ligand formation.

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E.

Viscosity-independent velocity of neutrophils rolling on p-selectin in vitro or in vivo.

Tracking leukocytes in vivo with shape and size constrained active contours.

LFA-1 is required for retention of effector CD8 T cells in mouse lungs.

Single injection of P-selectin or P-selectin glycoprotein ligand-1 monoclonal antibody blocks neointima formation after arterial injury in apolipoprotein E-deficient mice.

P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules.

Cerebral vasospasm after subarachnoid hemorrhage: putative role of inflammation.

The role of selectins in inflammation and disease.

Near-wall micro-PIV reveals a hydrodynamically relevant endothelial surface layer in venules in vivo.

Arrest chemokines.

Healing without inflammation?

Rosiglitazone reduces the accelerated neointima formation after arterial injury in a mouse injury model of type 2 diabetes.

Local-pooled-error test for identifying differentially expressed genes with a small number of replicated microarrays.

Sulfated sugars for rolling lymphocytes.

Mac-1, but not LFA-1, uses intercellular adhesion molecule-1 to mediate slow leukocyte rolling in TNF-alpha-induced inflammation.

Leukocyte recruitment and acute renal failure.

Role of platelets in the development of atherosclerosis.

Weird and weirder: how circulating chemokines coax neutrophils to the lung.

Critical role of platelet P-selectin in the response to arterial injury in apolipoprotein-E-deficient mice.

Autoperfused mouse flow chamber reveals synergistic neutrophil accumulation through P-selectin and E-selectin.

Binding and detachment dynamics of microbubbles targeted to P-selectin under controlled shear flow.

选择素在 T 细胞招聘非淋巴组织和炎症的站点中。

Alpha4beta1 integrin (VLA-4) blockade attenuates both early and late leukocyte recruitment and neointimal growth following carotid injury in apolipoprotein E (-/-) mice.

Microviscometry reveals reduced blood viscosity and altered shear rate and shear stress profiles in microvessels after hemodilution.

Vav GEFs are required for beta2 integrin-dependent functions of neutrophils.

Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease.

A novel method to analyze leukocyte rolling behavior in vivo.

Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response.

Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice.

CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo.

Bench-to-bedside review: acute respiratory distress syndrome - how neutrophils migrate into the lung.

Oxidative modification of leukocyte adhesion.

Linkage to peroxisome proliferator-activated receptor-gamma in SAMP1/YitFc mice and in human Crohn's disease.

L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine.

Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17.

GRO family chemokines are specialized for monocyte arrest from flow.

Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury.

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720.

Macrophage differentiation to foam cells.

The platelet microparticle proteome.

Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720.

Preferential migration of effector CD8+ T cells into the interstitium of the normal lung.

Arterial macrophages and regenerating endothelial cells express P-selectin in atherosclerosis-prone apolipoprotein E-deficient mice.

Signals for lymphocyte egress.

Leukocyte recruitment and vascular injury in diabetic nephropathy.

Double jeopardy: how soluble P-selectin activates leukocytes in peripheral arterial occlusive disease.

Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn's disease.

Induction of LFA-1-dependent neutrophil rolling on ICAM-1 by engagement of E-selectin.

ICAM-1 and LFA-1 play critical roles in LPS-induced neutrophil recruitment into the alveolar space.

Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung.

The primary defect in experimental ileitis originates from a nonhematopoietic source.

Protective effects of isoflurane pretreatment in endotoxin-induced lung injury.

Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis.

Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent.

Deformable gas-filled microbubbles targeted to P-selectin.

IL-17A-producing neutrophil-regulatory Tn lymphocytes.

Hold on to your endothelium: postarrest steps of the leukocyte adhesion cascade.

Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor.

Platelet-neutrophil-interactions: linking hemostasis and inflammation.

Leukocyte phosphoinositide-3 kinase {gamma} is required for chemokine-induced, sustained adhesion under flow in vivo.

Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis.

Alpha 2,3-sialyltransferase-IV is essential for L-selectin ligand function in inflammation.

Analysis of leukocyte rolling in vivo and in vitro.

Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation.

Proteomic discovery of 21 proteins expressed in human plasma-derived but not platelet-derived microparticles.

Induction of dendritic cell-like phenotype in macrophages during foam cell formation.

Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration.

Dynamics of in silico leukocyte rolling, activation, and adhesion.

Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK.

Enhanced targeting of ultrasound contrast agents using acoustic radiation force.

Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1.

Effects of native and modified low-density lipoproteins on monocyte recruitment in atherosclerosis.

Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injury.

Vascular adhesion molecules in atherosclerosis.

Galphai2 is required for chemokine-induced neutrophil arrest.

Getting to the site of inflammation: the leukocyte adhesion cascade updated.

The Duffy antigen receptor for chemokines in acute renal failure: A facilitator of renal chemokine presentation.

Statistical identification of differentially labeled peptides from liquid chromatography tandem mass spectrometry.

CXCR6 promotes atherosclerosis by supporting T-cell homing, interferon-gamma production, and macrophage accumulation in the aortic wall.

Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity.

CXCL4 in atherosclerosis: possible roles in monocyte arrest and macrophage foam cell formation.

IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice.

Mechanisms and consequences of neutrophil interaction with the endothelium.

From lung injury to fibrosis.

Leukocyte influx in atherosclerosis.

CD40 ligand promotes Mac-1 expression, leukocyte recruitment, and neointima formation after vascular injury.

Upregulation of aldose reductase during foam cell formation as possible link among diabetes, hyperlipidemia, and atherosclerosis.

Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells.

Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation.

Leukocyte adhesion molecules in animal models of inflammatory bowel disease.

IL-17A inhibits the expansion of IL-17A-producing T cells in mice through "short-loop" inhibition via IL-17 receptor.

Plasma-derived microparticles for biomarker discovery.

Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice.

Mechanisms by which diabetes increases cardiovascular disease.

Platelet chemokines in vascular disease.

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling.

Homeostatic regulation of blood neutrophil counts.

Dances with leukocytes: how tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms.

Chapter 11. Intravital microscopic investigation of leukocyte interactions with the blood vessel wall.

Event-tracking model of adhesion identifies load-bearing bonds in rolling leukocytes.

Neutrophil adhesion and activation under flow.

Transcriptional regulation of mouse L-selectin.

Monocyte-endothelial cell interactions in the development of atherosclerosis.

Cell adhesion under flow.

The role of platelets in acute lung injury (ALI).

Immune and inflammatory mechanisms of atherosclerosis (*).

Micro-PTV measurement of the fluid shear stress acting on adherent leukocytes in vivo.

DARC on RBC limits lung injury by balancing compartmental distribution of CXC chemokines.

New insights into leukocyte recruitment by intravital microscopy.

IL-17A controls IL-17F production and maintains blood neutrophil counts in mice.

Glycosylation in immune cell trafficking.

PSGL-1-dependent myeloid leukocyte activation.

Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI).

Opening the flood-gates: how neutrophil-endothelial interactions regulate permeability.

T-lineage cells require the thymus but not VDJ recombination to produce IL-17A and regulate granulopoiesis in vivo.

Tyrosine sulfation of leukocyte adhesion molecules and chemokine receptors promotes atherosclerosis.

CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages.

Dynamics of Microvillus Extension and Tether Formation in Rolling Leukocytes.

ReSASC: a resampling-based algorithm to determine differential protein expression from spectral count data.

Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: implications for thrombus formation.

Development of monocytes, macrophages, and dendritic cells.

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways.

The transmembrane domains of L-selectin and CD44 regulate receptor cell surface positioning and leukocyte adhesion under flow.

CXC chemokine ligand 4 induces a unique transcriptome in monocyte-derived macrophages.

Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice.

Mycophenolic acid suppresses granulopoiesis by inhibition of interleukin-17 production.

Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils.

Defective regulation of CXCR2 facilitates neutrophil release from bone marrow causing spontaneous inflammation in severely NF-kappa B-deficient mice.

The mysterious ways of the chemokine CXCL5.

Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells.

scVEGF microbubble ultrasound contrast agents: a novel probe for ultrasound molecular imaging of tumor angiogenesis.

Quantitative dynamic footprinting microscopy reveals mechanisms of neutrophil rolling.

Beta7 integrin deficiency suppresses B cell homing and attenuates chronic ileitis in SAMP1/YitFc mice.

The plasma microparticle proteome.

Interleukin 17 in vascular inflammation.

Protein kinase C isoforms in neutrophil adhesion and activation.

Protein tyrosine kinases in neutrophil activation and recruitment.

Live cell imaging of paxillin in rolling neutrophils by dual-color quantitative dynamic footprinting.

Cell protrusions and tethers: a unified approach.

Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling.

Biomechanics of leukocyte rolling.

SAMP1/YitFc mouse strain: a spontaneous model of Crohn's disease-like ileitis.

Mycophenolate mofetil decreases atherosclerotic lesion size by depression of aortic T-lymphocyte and interleukin-17-mediated macrophage accumulation.

Adam17-dependent shedding limits early neutrophil influx but does not alter early monocyte recruitment to inflammatory sites.

Monocyte and macrophage dynamics during atherogenesis.

How dendritic cells shape atherosclerosis.

Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease.

High refractive index silicone gels for simultaneous total internal reflection fluorescence and traction force microscopy of adherent cells.

CD63 positions CD62P for rolling.

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow.

B-cell aortic homing and atheroprotection depend on Id3.

NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases Atherosclerosis.

Accelerated atherosclerosis in apoe-/- mice heterozygous for the insulin receptor and the insulin receptor substrate-1.