Mayra Furlan-Magaril

Nuclear Dynamics Programme,
The Babraham Institute,
Nuclear Dynamics Programme, The Babraham Institute

Babraham Research Campus

BIOGRAPHY

Mayra is a molecular biologist specialized in epigenetics and genome architecture dedicated to understand how genome 3D conformation contributes to gene expression control and genomic stability.

Mayra studied her PhD at the UNAM in Mexico City investigating the function of a CTCF dependent insulator within the alfa-globin gene domain. As a postdoc Mayra became a fellow at the Babraham Institute in Cambridge, UK and continued to characterize structural components of the genome and their function.

Currently Mayra is a junior group leader at the Cellular Physiology Institute at the UNAM. Her research group is investigating the function of genome structure in gene expression control.

PUBLICATIONS

Neural stem cells in development and regenerative medicine.

Archives of medical research Nov-Dec, 2003 | Pubmed ID: 14734098

Globin genes transcriptional switching, chromatin structure and linked lessons to epigenetics in cancer: a comparative overview.

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Jul, 2007 | Pubmed ID: 17188536

Protection against telomeric position effects by the chicken cHS4 beta-globin insulator.

Proceedings of the National Academy of Sciences of the United States of America Aug, 2007 | Pubmed ID: 17715059

Sequential chromatin immunoprecipitation protocol: ChIP-reChIP.

Methods in molecular biology (Clifton, N.J.) , 2009 | Pubmed ID: 19378171

An insulator embedded in the chicken α-globin locus regulates chromatin domain configuration and differential gene expression.

Nucleic acids research Jan, 2011 | Pubmed ID: 20813760

The Krüppel-like factor 4 controls biosynthesis of thyrotropin-releasing hormone during hypothalamus development.

Molecular and cellular endocrinology Feb, 2011 | Pubmed ID: 21182892

Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes.

Nature structural & molecular biology Jun, 2011 | Pubmed ID: 21602820

Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter.

BMC cancer Jun, 2011 | Pubmed ID: 21663659

The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements.

Genome research Apr, 2015 | Pubmed ID: 25752748

Individual and Sequential Chromatin Immunoprecipitation Protocols.

Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 26404152

Lineage-specific dynamic and pre-established enhancer-promoter contacts cooperate in terminal differentiation.

Nature genetics Oct, 2017 | Pubmed ID: 28805829

Shaping Up the Embryo: The Role of Genome 3D Organization.

Methods in molecular biology (Clifton, N.J.) , 2018 | Pubmed ID: 29564771

RNA proximity sequencing reveals the spatial organization of the transcriptome in the nucleus.

Nature biotechnology 07, 2019 | Pubmed ID: 31267103

RNA Interactions Are Essential for CTCF-Mediated Genome Organization.

Molecular cell 11, 2019 | Pubmed ID: 31522988

In situ dissection of domain boundaries affect genome topology and gene transcription in Drosophila.

Nature communications 02, 2020 | Pubmed ID: 32060283

The global and promoter-centric 3D genome organization temporally resolved during a circadian cycle.

Genome biology 06, 2021 | Pubmed ID: 34099014

Editorial: Chromatin Spatial Configuration and Function in Metazoans.

Frontiers in genetics , 2021 | Pubmed ID: 34456981

INSTITUTIONS

Babraham Research Campus

Universidad Nacional Autónoma de México

JOVE ARTICLES

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Stefan Schoenfelder^*,1,

Biola-Maria Javierre^*,1,2,

Mayra Furlan-Magaril^1,3,

Steven W. Wingett^1,4,

Peter Fraser^1,5

¹Nuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus,

²IJC Building, Campus ICO-Germans Trias i Pujol, Josep Carreras Leukemia Research Institute,

³Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México,

⁴Bioinformatics Group, The Babraham Institute, Babraham Research Campus,

⁵Department of Biological Science, Florida State University

Genetics

In-Nucleus Hi-C in Drosophila Cells

Ayerim Esquivel-López¹,

Rodrigo Arzate-Mejía¹,

Rosario Pérez-Molina¹,

Mayra Furlan-Magaril¹

¹Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México

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Mayra Furlan-Magaril

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Babraham Research Campus

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

In-Nucleus Hi-C in Drosophila Cells

Nuclear Dynamics Programme,
The Babraham Institute,
Nuclear Dynamics Programme, The Babraham Institute