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Departments of Chemistry and Cell and Molecular Biology
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Highly selective cyclic peptide ligands for NeutrAvidin and avidin identified by phage display.
Chemical biology & drug design Jul, 2006 | Pubmed ID: 16923020
The AviD-tag, a NeutrAvidin/avidin specific peptide affinity tag for the immobilization and purification of recombinant proteins.
Protein expression and purification Nov, 2007 | Pubmed ID: 17697784
Tethering small molecules to a phage display library: discovery of a selective bivalent inhibitor of protein kinase A.
Journal of the American Chemical Society Nov, 2007 | Pubmed ID: 17944472
Directed evolution of recombinase specificity by split gene reassembly.
Nucleic acids research Jul, 2010 | Pubmed ID: 20194120
Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleases.
Journal of molecular biology Jul, 2010 | Pubmed ID: 20447404
Structure-guided reprogramming of serine recombinase DNA sequence specificity.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2011 | Pubmed ID: 21187418
Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase.
Nucleic acids research Sep, 2011 | Pubmed ID: 21653554
Targeted gene knockout by direct delivery of zinc-finger nuclease proteins.
Nature methods Aug, 2012 | Pubmed ID: 22751204
Chimeric TALE recombinases with programmable DNA sequence specificity.
Nucleic acids research Nov, 2012 | Pubmed ID: 23019222
A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells.
Nucleic acids research Apr, 2013 | Pubmed ID: 23393187
ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering.
Trends in biotechnology Jul, 2013 | Pubmed ID: 23664777
Expanding the scope of site-specific recombinases for genetic and metabolic engineering.
Biotechnology and bioengineering Jan, 2014 | Pubmed ID: 23982993
Regulation of endogenous human gene expression by ligand-inducible TALE transcription factors.
ACS synthetic biology Oct, 2014 | Pubmed ID: 24251925
Expanding the zinc-finger recombinase repertoire: directed evolution and mutational analysis of serine recombinase specificity determinants.
Nucleic acids research Apr, 2014 | Pubmed ID: 24452803
Cell-penetrating peptide-mediated delivery of TALEN proteins via bioconjugation for genome engineering.
PloS one , 2014 | Pubmed ID: 24465685
Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign.
Journal of the American Chemical Society Apr, 2014 | Pubmed ID: 24611715
Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies.
Accounts of chemical research Aug, 2014 | Pubmed ID: 24877793
Protein delivery using Cys2-His2 zinc-finger domains.
ACS chemical biology Aug, 2014 | Pubmed ID: 24936957
Site-selective labeling of a lysine residue in human serum albumin.
Angewandte Chemie (International ed. in English) Oct, 2014 | Pubmed ID: 25196737
Genome engineering with custom recombinases.
Methods in enzymology , 2014 | Pubmed ID: 25398336
Improved cell-penetrating zinc-finger nuclease proteins for precision genome engineering.
Molecular therapy. Nucleic acids , 2015 | Pubmed ID: 25756962
The Scripps Research Institute
Thomas Gaj*,1,
Jia Liu*,1,2
1Departments of Chemistry and Cell and Molecular Biology, The Scripps Research Institute,
2Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University
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