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Department of Biomedical Physiology and Kinesiology
Thomas W. Claydon has not added Biography.
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Closed-state inactivation induced in K(V)1 channels by extracellular acidification.
Channels (Austin, Tex.) Mar-Apr, 2008 | Pubmed ID: 18849651
Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.
Biophysical journal Mar, 2014 | Pubmed ID: 24606930
The Zebrafish Heart as a Model of Mammalian Cardiac Function.
Reviews of physiology, biochemistry and pharmacology , 2016 | Pubmed ID: 27538987
Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker.
Biophysical journal Jan, 2017 | Pubmed ID: 28122216
Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy.
American journal of human genetics Jul, 2017 | Pubmed ID: 28669405
Functional characterization of a novel hERG variant in a family with recurrent sudden infant death syndrome: Retracting a genetic diagnosis.
Forensic science international Mar, 2018 | Pubmed ID: 29331839
Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype.
Scientific reports 03, 2018 | Pubmed ID: 29563525
Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation.
The Journal of general physiology 02, 2019 | Pubmed ID: 30530765
Modulation of hERG K Channel Deactivation by Voltage Sensor Relaxation.
Frontiers in pharmacology , 2020 | Pubmed ID: 32184724
The hERG channel activator, RPR260243, enhances protective current early in the refractory period reducing arrhythmogenicity in zebrafish hearts.
American journal of physiology. Heart and circulatory physiology 08, 2020 | Pubmed ID: 32559136
Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243.
The Journal of general physiology 10, 2021 | Pubmed ID: 34398210
Ion channel model reduction using manifold boundaries.
Journal of the Royal Society, Interface Aug, 2022 | Pubmed ID: 35946166
Simon Fraser University
Kyle E. Simpson1,
Shoaib Faizi1,
Ravichandra Venkateshappa1,
Mandy Yip1,
Raj Johal1,
Damon Poburko1,
Yen May Cheng1,
Diana Hunter1,
Eric Lin1,
Glen F. Tibbits1,
Thomas W. Claydon1
1Department of Biomedical Physiology and Kinesiology, Simon Fraser University
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