Uwe-Karsten Hanisch

Microglia as a source and target of cytokines.

Interferon-gamma differentially modulates the release of cytokines and chemokines in lipopolysaccharide- and pneumococcal cell wall-stimulated mouse microglia and macrophages.

Elevation of basal intracellular calcium as a central element in the activation of brain macrophages (microglia): suppression of receptor-evoked calcium signaling and control of release function.

Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation in vitro.

Expression of proteinase-activated receptors in mouse microglial cells.

Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis.

The tyrosine kinase inhibitor AG126 restores receptor signaling and blocks release functions in activated microglia (brain macrophages) by preventing a chronic rise in the intracellular calcium level.

The microglia-activating potential of thrombin: the protease is not involved in the induction of proinflammatory cytokines and chemokines.

Microglia.

c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia.

Unraveling thrombin's true microglia-activating potential: markedly disparate profiles of pharmaceutical-grade and commercial-grade thrombin preparations.

Microglial phenotype: is the commitment reversible?

Activation of microglial cells by thrombin: past, present, and future.

A paediatric supratentorial primitive neuroectodermal tumour associated with malignant astrocytic transformation and a clonal origin of both components.

Fibronectin is elevated in the cerebrospinal fluid of patients suffering from bacterial meningitis and enhances inflammation caused by bacterial products in primary mouse microglial cell cultures.

Lipopolysaccharide is a frequent and significant contaminant in microglia-activating factors.

Microglia: active sensor and versatile effector cells in the normal and pathologic brain.

Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions.

Myelin-phagocytosing macrophages in isolated sciatic and optic nerves reveal a unique reactive phenotype.

Toll-like receptors: roles in neuroprotection?

Thrombin regulates CD40 expression in microglial cells.

Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system.

Inhibition of Rho-dependent pathways by Clostridium botulinum C3 protein induces a proinflammatory profile in microglia.

Thrombin-induced regulation of CD95(Fas) expression in the N9 microglial cell line: evidence for involvement of proteinase-activated receptor(1) and extracellular signal-regulated kinase 1/2.

Toll-like receptor prestimulation increases phagocytosis of Escherichia coli DH5alpha and Escherichia coli K1 strains by murine microglial cells.

FK506 protects against various immune responses and secondary degeneration following cerebral ischemia.

Fibronectin stimulates Escherichia coli phagocytosis by microglial cells.

Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia.

Therapeutic and adverse effects of a non-steroidal glucocorticoid receptor ligand in a mouse model of multiple sclerosis.

TRPM3 is expressed in sphingosine-responsive myelinating oligodendrocytes.

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine.

T cell-dependence of Lassa fever pathogenesis.

Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way.

Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid.

The viral TLR3 agonist poly(I:C) stimulates phagocytosis and intracellular killing of Escherichia coli by microglial cells.

Inflammatory cytokine release of astrocytes in vitro is reduced by all-trans retinoic acid.

CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS.

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis.

Physiology of microglia.

Expression of coagulation factors and their receptors in tumor tissue and coagulation factor upregulation in peripheral blood of patients with cerebral carcinoma metastases.

Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination.

Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin.

The nucleotide-binding oligomerization domain-containing-2 ligand muramyl dipeptide enhances phagocytosis and intracellular killing of Escherichia coli K1 by Toll-like receptor agonists in microglial cells.

Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia.

Influence of methylene blue on microglia-induced inflammation and motor neuron degeneration in the SOD1(G93A) model for ALS.

Proteins in microglial activation--inputs and outputs by subsets.

Resistance of the brain to Escherichia coli K1 infection depends on MyD88 signaling and the contribution of neutrophils and monocytes.

Histone deacetylase inhibitors suppress immune activation in primary mouse microglia.

Functional diversity of microglia - how heterogeneous are they to begin with?

Carcinoma cells misuse the host tissue damage response to invade the brain.

Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam3CSK 4 (BLP).

Toll-like receptor 2 mediates microglia/brain macrophage MT1-MMP expression and glioma expansion.

Zoledronic acid inhibits macrophage/microglia-assisted breast cancer cell invasion.