John Marshall

Comparing safety and efficacy of first-line irinotecan/fluoropyrimidine combinations in elderly versus nonelderly patients with metastatic colorectal cancer: findings from the bolus, infusional, or capecitabine with camptostar-celecoxib study.

Evaluation of [64Cu]Cu-DOTA and [64Cu]Cu-CB-TE2A chelates for targeted positron emission tomography with an alphavbeta6-specific peptide.

Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathway.

Too much information.

Biomarkers of sepsis.

The effect of gene drive on containment of transgenic mosquitoes.

3D collagen orientation study of the human cornea using X-ray diffraction and femtosecond laser technology.

Targeted in vivo imaging of integrin alphavbeta6 with an improved radiotracer and its relevance in a pancreatic tumor model.

Development and validation of a risk score for post-infectious irritable bowel syndrome.

The 'Consent to Research' paradigm in critical care: challenges and potential solutions.

Estradiol and progesterone-induced slowing of gonadotropin-releasing hormone pulse frequency is not reversed by subsequent administration of mifepristone.

SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway.

Heading in the right direction.

Post-infectious irritable bowel syndrome.

Tandem mass spectrometry of human tryptic blood peptides calculated by a statistical algorithm and captured by a relational database with exploration by a general statistical analysis system.

Regulation of Lhb and Egr1 gene expression by GNRH pulses in rat pituitaries is both c-Jun N-terminal kinase (JNK)- and extracellular signal-regulated kinase (ERK)-dependent.

Ten reasons why we should NOT use severity scores as entry criteria for clinical trials or in our treatment decisions.

ISGIO: Setting the Standard of Care for the Future.

Safety of chronic low-dose capecitabine as maintenance therapy in gastrointestinal cancers.

Effect of epithelial retention and removal on riboflavin absorption in porcine corneas.

Evaluation and stages of surgical innovations.

Challenges in evaluating surgical innovation.

No surgical innovation without evaluation: the IDEAL recommendations.

Reversal-specific learning impairments after a binge regimen of methamphetamine in rats: possible involvement of striatal dopamine.

Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses.

High-throughput in vivo screening of targeted molecular imaging agents.

Adherence to guidelines for surveillance colonoscopy in patients with ulcerative colitis at a Canadian quaternary care hospital.

Myocardial infarction, peptic ulcer and acetylsalicylic acid: of good and evil.

Is levoleucovorin an alternative to racemic leucovorin? A literature review.

Critically ill patients with 2009 influenza A(H1N1) infection in Canada.

Revascularization for coronary artery disease: stents versus bypass surgery.

Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis.

Storage and transpiration have negligible effects on delta13C of stem CO2 efflux in large conifer trees.

Coupling tree-ring delta13C and delta15N to test the effect of fertilization on mature Douglas-fir (Pseudotsuga menziesii var. glauca) stands across the Interior northwest, USA.

Principles of source control in the management of sepsis.

Cardiac arrest with residual blindness after overdose of Tessalon® (benzonatate) perles.

Analysis of low-concentration gas samples with continuous-flow isotope ratio mass spectrometry: eliminating sources of contamination to achieve high precision.

Evaluation of hypertension as a marker of bevacizumab efficacy.

A sensitizing D-amphetamine dose regimen induces long-lasting spinophilin and VGLUT1 protein upregulation in the rat diencephalon.

International study of the prevalence and outcomes of infection in intensive care units.

Comparison of flat-panel digital to conventional film-screen radiography in detection of experimentally created lesions of the equine third metacarpal bone.

High molecular-weight gelatinase species of human Bruch's membrane: compositional analyses and age-related changes.

CAGS and ACS evidence based reviews in surgery. 31. The use of intensive insulin therapy and pentastarch resuscitation in patients with severe sepsis.

Accomplishments in 2008 in the adjuvant treatment of colon cancer.

Assessing the educational needs of Canadian gastroenterologists and gastroenterology nurses: challenges to optimal care in Crohn's Disease.

A comprehensive catalogue of somatic mutations from a human cancer genome.

A small-cell lung cancer genome with complex signatures of tobacco exposure.

Vascular Endothelial Growth Factor plus Epidermal Growth Factor Receptor Dual Targeted Therapy in Metastatic Colorectal Cancer: Synergy or Antagonism?

From the bedside back to the bench: the role of preclinical studies in understanding clinical therapies.

Clinical research ethics for critically ill patients: a pandemic proposal.

Precipitation and selective extraction of human serum endogenous peptides with analysis by quadrupole time-of-flight mass spectrometry reveals posttranslational modifications and low-abundance peptides.

The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis.

Increased sequestration of matrix metalloproteinases in ageing human Bruch's membrane: implications for ECM turnover.

Genetic risk factors for post-infectious irritable bowel syndrome following a waterborne outbreak of gastroenteritis.

The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis.

An exploratory study of the characteristics of an admired leader.

Pancreatic cancer organotypic cultures.

Molecular changes associated with altered patterns of norovirus outbreak epidemics in Victoria, Australia, in 2006 to 2007.

Rectal 5-aminosalicylic acid for induction of remission in ulcerative colitis.

Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis.

Early observational research and registries during the 2009-2010 influenza A pandemic.

Prevalence of uninvestigated dyspepsia 8 years after a large waterborne outbreak of bacterial dysentery: a cohort study.

Inhibition of transforming growth factor-beta1 and its effects on human corneal fibroblasts by mannose-6-phosphate Potential for preventing haze after refractive surgery.

Molecular and epidemiological characteristics of norovirus associated with community-based sporadic gastroenteritis incidents and norovirus outbreaks in Victoria, Australia, 2002-2007.

Should my patient with inflammatory bowel disease on immunosuppressive therapy be vaccinated against influenza virus?

Effect of intraocular lens asphericity on vertical coma aberration.

Meta sequence analysis of human blood peptides and their parent proteins.

Phase 1 experience with an anti-glycotope monoclonal antibody, RAV12, in recurrent adenocarcinoma.

An outbreak of acute bacterial gastroenteritis is associated with an increased incidence of irritable bowel syndrome in children.

Keratorefractive effect of microwave keratoplasty on human corneas.

The endogenous peptides of normal human serum extracted from the acetonitrile-insoluble precipitate using modified aqueous buffer with analysis by LC-ESI-Paul ion trap and Qq-TOF.

Evaluation of pneumonia severity and acute physiology scores to predict ICU admission and mortality in patients hospitalized for influenza.

Risk assessment in Stage II colorectal cancer.

Phylogeographic analysis and environmental niche modeling of the plain-bellied watersnake (Nerodia erythrogaster) reveals low levels of genetic and ecological differentiation.

Impact of selective decontamination of the digestive tract on multiple organ dysfunction syndrome: systematic review of randomized controlled trials.

Improved management of lysosomal glucosylceramide levels in a mouse model of type 1 Gaucher disease using enzyme and substrate reduction therapy.

Neurotoxic methamphetamine regimens produce long-lasting changes in striatal G-proteins.

Hyperandrogenemia in obese peripubertal girls: correlates and potential etiological determinants.

Fighting a smarter war on cancer.

Patient outcomes after anti TNF-alpha drugs for Crohn's disease.

Live or Let Die: Epithelial Flap Vitality and Keratocyte Proliferation Following LASEK and Epi-LASIK in Human Donor and Porcine Eyes.

Eight year prognosis of postinfectious irritable bowel syndrome following waterborne bacterial dysentery.

Pilot study of new focus-shift accommodating intraocular lens.

Anterior chamber depth measurements in eyes with an accommodating intraocular lens: agreement between partial coherence interferometry and optical coherence tomography.

Perspectives of people in Mali toward genetically-modified mosquitoes for malaria control.

Endotoxin in the pathogenesis of sepsis.

IgGâ‚„-related sclerosing disease: a novel mimic of inflammatory bowel disease.

The Surviving Sepsis Campaign: a history and a perspective.

Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma.

Optical coherence tomography may be used to predict visual acuity in patients with macular edema.

Demographic characteristics of horses donated to the North Carolina State University Equine Health Center, 1996-2008.

Inhibition of glycogen biosynthesis via mTORC1 suppression as an adjunct therapy for Pompe disease.

A role for p11 in the antidepressant action of brain-derived neurotrophic factor.

Regulation of apoptosis and priming of neutrophil oxidative burst by diisopropyl fluorophosphate.

High-resolution in vivo imaging of breast cancer by targeting the pro-invasive integrin alphavbeta6.

Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines.

In vitro lens capsule model for investigation of posterior capsule opacification.

Altered inhibitory κBα expression in LPS-stimulated alveolar macrophages following resuscitated hemorrhagic shock.

Statistical analysis plan of PROWESS SHOCK study.

Multi-modality therapy for metastatic colorectal cancer-ready for prime time?

Use of the double-pass technique to quantify ocular scatter in patients with uveitis: a pilot study.

The incidence of norovirus-associated gastroenteritis outbreaks in Victoria, Australia (2002-2007) and their relationship with rainfall.

Safety of capecitabine: a review.

Preexisting immunity and low expression in primates highlight translational challenges for liver-directed AAV8-mediated gene therapy.

A neurotoxic regimen of methamphetamine impairs novelty recognition as measured by a social odor-based task.

The Cartagena Protocol and genetically modified mosquitoes.

Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin αvβ6 protein-peptide interactions.

H1N1: communication patterns among emergency department staff during the H1N1 outbreak, April 2009.

Age-related differences in the elasticity of the human cornea.

Norovirus GII.4 variant 2006b caused epidemics of acute gastroenteritis in Australia during 2007 and 2008.

Role of dopamine D1 receptors in the activation of nucleus accumbens extracellular signal-regulated kinase (ERK) by cocaine-paired contextual cues.

Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.

Chi-square comparison of tryptic peptide-to-protein distributions of tandem mass spectrometry from blood with those of random expectation.

Mass spectrometry of peptides and proteins from human blood.

Semele: a killer-male, rescue-female system for suppression and replacement of insect disease vector populations.

Role of probiotics in management of diverticular disease.

CAGS and ACS evidence based reviews in surgery. 35: Efficacy and safety of low-dose hydrocortisone therapy in the treatment of septic shock.

Substrate reduction augments the efficacy of enzyme therapy in a mouse model of Fabry disease.

Peptide-to-protein distribution versus a competition for significance to estimate error rate in blood protein identification.

Pulse labeling of dissolved (13) C-carbonate into tree xylem: developing a new method to determine the fate of recently fixed photosynthate.

Critical illness is an iatrogenic disorder.

Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.

Stromal features are predictive of disease mortality in oral cancer patients.

Relationship of catheter-associated urinary tract infection to mortality and length of stay in critically ill patients: a systematic review and meta-analysis of observational studies.

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

Minimum velocity necessary for nonconventional projectiles to penetrate the eye: an experimental study using pig eyes.

Evaluation of the cyclooxygenase selectivity of robenacoxib and its effect on recovery of ischemia-injured jejunal mucosa in horses.

Stratigraphy of the Anthropocene.

Serum 25-hydroxyvitamin D is independently associated with high-density lipoprotein cholesterol and the metabolic syndrome in men and women.

Stromal features are predictive of disease mortality in oral cancer patients.

Evaluation of the RIDA(®)QUICK immunochromatographic norovirus detection assay using specimens from Australian gastroenteritis incidents.

Effects of prescription omega-3-acid ethyl esters on fasting lipid profile in subjects with primary hypercholesterolemia.

Principles of source control in the early management of sepsis.

The Global Sepsis Alliance: building new collaborations to confront an under-recognized threat.

Principles of source control in the management of sepsis.

Incidence of complications after colonoscopy: capturing an elusive beast.

Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study.

A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial.

Changes in coping style and treatment outcome following motor vehicle accident.

Cost-utility of laparoscopic Nissen fundoplication versus proton pump inhibitors for chronic and controlled gastroesophageal reflux disease: a 3-year prospective randomized controlled trial and economic evaluation.

Glucocorticosteroid therapy in inflammatory bowel disease: systematic review and meta-analysis.

Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis.

Efficacy of 5-aminosalicylates in ulcerative colitis: systematic review and meta-analysis.

Efficacy of 5-aminosalicylates in Crohn's disease: systematic review and meta-analysis.

GnRH pulse frequency differentially regulates steroidogenic factor 1 (SF1), dosage-sensitive sex reversal-AHC critical region on the X chromosome gene 1 (DAX1), and serum response factor (SRF): potential mechanism for GnRH pulse frequency regulation of LH beta transcription in the rat.

Inverse Medea as a novel gene drive system for local population replacement: a theoretical analysis.

Disturbed matrix metalloproteinase activity of Bruch's membrane in age-related macular degeneration.

A randomized controlled trial of laparoscopic Nissen fundoplication versus proton pump inhibitors for the treatment of patients with chronic gastroesophageal reflux disease (GERD): 3-year outcomes.

Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans.

Pre-B cell colony-enhancing factor (PBEF/Nampt/visfatin) primes neutrophils for augmented respiratory burst activity through partial assembly of the NADPH oxidase.

The relationship between health care and nonhealth care norovirus outbreak settings and norovirus genotype in Victoria, Australia, 2002-2005.

The Age of Blood Evaluation (ABLE) randomized controlled trial: study design.

Vertical and seasonal variation in the δ¹³C of leaf-respired CO₂ in a mixed conifer forest.

Estimation of canopy average mesophyll conductance using δ(13) C of phloem contents.

Striatal dopamine D1 and D2 receptors: Widespread influences on methamphetamine-induced dopamine and serotonin neurotoxicity.

The role of α9β1 integrin in modulating epithelial cell behaviour.

Proceedings from the Montebello Round Table Discussion. Second annual conference on Complexity and Variability discusses research that brings innovation to the bedside.

Bowel preparation with split-dose polyethylene glycol before colonoscopy: a meta-analysis of randomized controlled trials.

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia.

Work aversion and associated changes in dopamine and serotonin transporter after methamphetamine exposure in rats.

Unblinding plan of PROWESS-SHOCK trial.

Acute pain management curriculum for emergency medicine residency programs.

The dynamics of norovirus outbreak epidemics: recent insights.

Systemic administration of AAV8-α-galactosidase A induces humoral tolerance in nonhuman primates despite low hepatic expression.

BTB-Kelch proteins and ubiquitination of kainate receptors.

Endoscopic transsphenoidal surgery for acromegaly: remission using modern criteria, complications, and predictors of outcome.

A phase I trial of bexarotene in combination with docetaxel in patients with advanced solid tumors.

Tissue and serum microRNAs in the Kras(G12D) transgenic animal model and in patients with pancreatic cancer.

Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease.

Transwell(®) invasion assays.

A phase 1 study of a vaccine targeting preferentially expressed antigen in melanoma and prostate-specific membrane antigen in patients with advanced solid tumors.

Readiness for change predicts outcomes of functional rehabilitation following motor vehicle accident.

Increased mortality associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in the intensive care unit: results from the EPIC II study.

Transscleral albumin diffusion and suprachoroidal albumin concentration in uveal effusion syndrome.

Management of Patients With Nonvariceal Upper Gastrointestinal Bleeding.

Stability of serrated gold coil markers in prostate localization.

Dopamine D1 receptor antagonism impairs extinction of cocaine-cue memories.

The toxin and antidote puzzle: new ways to control insect pest populations through manipulating inheritance.

Should albumin be used in all patients with spontaneous bacterial peritonitis?

The Fc receptor-cytoskeleton complex from human neutrophils.

Estimation of estradiol in mouse serum samples: evaluation of commercial estradiol immunoassays.

Running wheel exercise ameliorates methamphetamine-induced damage to dopamine and serotonin terminals.

An inexpensive, fast, and reliable method for vacuum extraction of soil and plant water for stable isotope analyses by mass spectrometry.

Development and independent validation of a prognostic assay for stage II colon cancer using formalin-fixed paraffin-embedded tissue.

Role of androgen receptor CAG repeat polymorphism length in hypothalamic progesterone sensitivity in hyperandrogenic adolescent girls.

Confinement of gene drive systems to local populations: a comparative analysis.

Treatment of hospitalized adult patients with severe ulcerative colitis: toronto consensus statements.

Identification and quantification of peptides and proteins secreted from prostate epithelial cells by unbiased liquid chromatography tandem mass spectrometry using goodness of fit and analysis of variance.

Philanthropy, advocacy and colon cancer.

Knowledge and attitudes regarding expanded genetic carrier screening among women's healthcare providers.

Neuroendocrine dysfunction in polycystic ovary syndrome.

Fluid Resuscitation with 5% albumin versus Normal Saline in Early Septic Shock: A pilot randomized, controlled trial.

Should all women with PCOS be treated for insulin resistance?

The PRECISE RCT: Evolution of an Early Septic Shock Fluid Resuscitation Trial.

Canadian cost-utility analysis of initiation and maintenance treatment with anti-TNF-α drugs for refractory Crohn's disease.

Fecal Transplant via Retention Enema for Refractory or Recurrent Clostridium difficile Infection.

Capture and qualitative analysis of the activated fc receptor complex from live cells.

Quantitative statistical analysis of standard and human blood proteins from liquid chromatography, electrospray ionization and tandem mass spectrometry.

S100P-Binding Protein, S100PBP, Mediates Adhesion through Regulation of Cathepsin Z in Pancreatic Cancer Cells.

Phase I trial of ixabepilone administered as three oral doses each separated by 6 hours every 3 weeks in patients with advanced solid tumors.