Daniel T. Laskowitz

Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema.

The impact of postoperative atrial fibrillation on neurocognitive outcome after coronary artery bypass graft surgery.

Apolipoprotein E isoform mediated regulation of nitric oxide release.

Differential cerebral gene expression during cardiopulmonary bypass in the rat: evidence for apoptosis?

Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis.

Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase.

Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage.

Apolipoprotein E protects against NMDA excitotoxicity.

Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage.

Apolipoprotein E4 increases aortic atheroma burden in cardiac surgical patients.

Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery.

Apolipoprotein E expression and behavioral toxicity of high charge, high energy (HZE) particle radiation.

Leukocytosis as an independent risk factor for cerebral vasospasm following aneurysmal subarachnoid hemorrhage.

Early biomarkers of stroke.

APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response.

Novel diagnostic test for acute stroke.

Correlation of serum brain natriuretic peptide with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage.

Synthes Award for Resident Research in Spinal Cord & Spinal Column Injury: Statins for the treatment of neurological injury: a role beyond cholesterol lowering.

A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury.

Intrathecal administration of a novel apoE-derived therapeutic peptide improves outcome following perinatal hypoxic-ischemic injury.

Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial.

Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass.

APOE polymorphism is associated with risk of severe sepsis in surgical patients.

Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model.

A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage.

Changing outcome from aneurysmal subarachnoid hemorrhage: another step closer.

Galbraith Award: simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-response effect dependent on endothelial nitric oxide synthase.

Association of neurocognitive function and quality of life 1 year after coronary artery bypass graft (CABG) surgery.

Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis.

Central nervous system injury associated with cardiac surgery.

Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage.

Dissociation between vasospasm and functional improvement in a murine model of subarachnoid hemorrhage.

Can D-dimer levels identify patients at risk for early neurological deterioration in acute ischemic stroke?

Risk of cerebral vasopasm after subarachnoid hemorrhage reduced by statin therapy: A multivariate analysis of an institutional experience.

Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients.

Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway.

Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury.

COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury.

Apolipoprotein E and neurological disease: therapeutic potential and pharmacogenomic interactions.

Preclinical models of intracerebral hemorrhage: a translational perspective.

Statins in acute brain injury: getting the cart before the horse.

Challenges in enrollment of minority, pediatric, and geriatric patients in emergency and acute care clinical research.

Real-time 3-D contrast-enhanced transcranial ultrasound and aberration correction.

Management of post-subarachnoid hemorrhage vasospasm.

Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: new perspectives.

The use of S100B as a biomarker in subarachnoid hemorrhage: clarity in its promise and limits.

The ultrasound brain helmet: feasibility study of multiple simultaneous 3D scans of cerebral vasculature.

Clinical usefulness of a biomarker-based diagnostic test for acute stroke: the Biomarker Rapid Assessment in Ischemic Injury (BRAIN) study.

Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage.

Use of emergency department transcranial Doppler assessment of reperfusion after intravenous tPA for ischemic stroke.

Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery.

Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans.

S100B and brain natriuretic peptide predict functional neurological outcome after intracerebral haemorrhage.

Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice.

Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage.

Statins in traumatic brain injury.

Clinical application of blood biomarkers in cerebrovascular disease.

Engaging students in dedicated research and scholarship during medical school: the long-term experiences at Duke and Stanford.

Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury.

Defining optimal cerebral perfusion pressures in acute brain injury: a step toward individualization of care?

Discriminative capacity of biomarkers for acute stroke in the emergency department.

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease.

Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic.

Biomarkers in stroke: when will they impact care?

Progressive multifocal leukoencephalopathy with occult Waldenström macroglobulinemia.

Neuroprotection in subarachnoid hemorrhage.

A reversible aptamer improves outcome and safety in murine models of stroke and hemorrhage.

The ultrasound brain helmet: new transducers and volume registration for in vivo simultaneous multi-transducer 3-D transcranial imaging.

The apoE-mimetic peptide, COG1410, improves functional recovery in a murine model of intracerebral hemorrhage.

Statins improve outcome in murine models of intracranial hemorrhage and traumatic brain injury: A translational approach.

Evolving role of biomarkers in acute cerebrovascular disease.

Depression and antidepressant use after stroke and transient ischemic attack.

TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice.

Correlation of leukocytosis with early neurological deterioration following supratentorial intracerebral hemorrhage.

Biomarkers in traumatic brain injury.

Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity.

Letter by El Husseini et al regarding article, "What causes disability after transient ischemic attack and minor stroke?".

ApolipoproteinE mimetic peptides improve outcome after focal ischemia.

Lacosamide improves outcome in a murine model of traumatic brain injury.

Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury.

Simultaneous bilateral real-time 3-d transcranial ultrasound imaging at 1 MHz through poor acoustic windows.

Teaching neuroimages: vein of Galen aneurysm mimicking pineal mass in a young adult.

Interaction between sex and apolipoprotein e genetic background in a murine model of intracerebral hemorrhage.

Tumor necrosis factor α antagonism improves neurological recovery in murine intracerebral hemorrhage.

Predictors of late neurological deterioration after spontaneous intracerebral hemorrhage.

Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery.

A Blood-based Biomarker Panel to Detect Acute Stroke.

Predictors of extraventricular drain-associated bacterial ventriculitis.

3-D transcranial ultrasound imaging with bilateral phase aberration correction of multiple isoplanatic patches: a pilot human study with microbubble contrast enhancement.

Genetic influences and neuropathological sequelae of repetitive brain injury.

Gender and age interact to affect early outcome after intracerebral hemorrhage.

pH-sensitive NMDA inhibitors improve outcome in a murine model of SAH.

The role of neuroendocrine pathways in prognosis after stroke.

Response to letter regarding article, "Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery".

Statins and Delirium During Critical Illness: A Multicenter, Prospective Cohort Study.