Lawrence S.B. Goldstein

Adociasulfates 1-6, Inhibitors of Kinesin Motor Proteins from the Sponge Haliclona (aka Adocia) sp.

Principles of cargo attachment to cytoplasmic motor proteins.

A genetic screen for suppressors and enhancers of the Drosophila cdk1-cyclin B identifies maternal factors that regulate microtubule and microfilament stability.

Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease.

Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A.

JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins.

Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila.

Do disorders of movement cause movement disorders and dementia?

Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease.

Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction.

A standardized kinesin nomenclature.

Polyglutamine diseases and transport problems: deadly traffic jams on neuronal highways.

Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease.

Sunday Driver links axonal transport to damage signaling.

Kinesin-2 and photoreceptor cell death: requirement of motor subunits.

Linking molecular motors to Alzheimer's disease.

Axonal transport and Alzheimer's disease.

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

The genetics of axonal transport and axonal transport disorders.

Analysis of kinesin-2 function in photoreceptor cells using synchronous Cre-loxP knockout of Kif3a with RHO-Cre.

Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment.

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice.

Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides.

Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin.

Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects.

Examination of potential mechanisms of amyloid-induced defects in neuronal transport.

Sunday driver interacts with two distinct classes of axonal organelles.

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation.

Patients beware: commercialized stem cell treatments on the web.

Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies.

Unconventional allies: interdisciplinary approaches to science policy and funding.

Investigating synapse formation and function using human pluripotent stem cell-derived neurons.

Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles.

Somatic coding mutations in human induced pluripotent stem cells.

Cell-surface marker signatures for the isolation of neural stem cells, glia and neurons derived from human pluripotent stem cells.

A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila.

Decellularized porcine brain matrix for cell culture and tissue engineering scaffolds.

In the trenches: lessons for scientists from California's Proposition 71 campaign.

Kinesin light chain 1 suppression impairs human embryonic stem cell neural differentiation and amyloid precursor protein metabolism.

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.

Molecular motor function in axonal transport in vivo probed by genetic and computational analysis in Drosophila.

Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1.

Axonal transport and neurodegenerative disease: can we see the elephant?

Subpixel colocalization reveals amyloid precursor protein-dependent kinesin-1 and dynein association with axonal vesicles.

Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects.

Alzheimer's disease in a dish: promises and challenges of human stem cell models.

An October call to arms: we are research!

New frontiers in human cell biology and medicine: can pluripotent stem cells deliver?

ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia.

Endogenous GSK-3/shaggy regulates bidirectional axonal transport of the amyloid precursor protein.

A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition.

Using human-induced pluripotent stem cells to model monogenic metabolic disorders of the liver.

Presenilin controls kinesin-1 and dynein function during APP-vesicle transport in vivo.

The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in Drosophila.

Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation.

The presenilin-1 ΔE9 mutation results in reduced γ-secretase activity, but not total loss of PS1 function, in isogenic human stem cells.

Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function.

UV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport.

Biophysical challenges to axonal transport: motor-cargo deficiencies and neurodegeneration.

Long-distance axonal growth from human induced pluripotent stem cells after spinal cord injury.

Effect of Potent γ-Secretase Modulator in Human Neurons Derived From Multiple Presenilin 1-Induced Pluripotent Stem Cell Mutant Carriers.